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Erschienen in: Inflammopharmacology 6/2023

10.11.2023 | Review

Recent advances in anti-inflammatory active components and action mechanisms of natural medicines

verfasst von: Zhimin Wu, Tao Zhang, Xiaofei Ma, Shuai Guo, Qingqing Zhou, Arshad Zahoor, Ganzhen Deng

Erschienen in: Inflammopharmacology | Ausgabe 6/2023

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Abstract

Inflammation is a series of reactions caused by the body’s resistance to external biological stimuli. Inflammation affects the occurrence and development of many diseases. Anti-inflammatory drugs have been used widely to treat inflammatory diseases, but long-term use can cause toxic side-effects and affect human functions. As immunomodulators with long-term conditioning effects and no drug residues, natural products are being investigated increasingly for the treatment of inflammatory diseases. In this review, we focus on the inflammatory process and cellular mechanisms in the development of diseases such as inflammatory bowel disease, atherosclerosis, and coronavirus disease-2019. Also, we focus on three signaling pathways (Nuclear factor-kappa B, p38 mitogen-activated protein kinase, Janus kinase/signal transducer and activator of transcription-3) to explain the anti-inflammatory effect of natural products. In addition, we also classified common natural products based on secondary metabolites and explained the association between current bidirectional prediction progress of natural product targets and inflammatory diseases.
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Zurück zum Zitat Jia X, Iwanowycz S, Wang J, Saaoud F, Yu F, Wang Y, Hu J, Chatterjee S, Wang Q, Fan D (2014) Emodin attenuates systemic and liver inflammation in hyperlipidemic mice administrated with lipopolysaccharides. Exp Biol Med 239(8):1025–1035CrossRef Jia X, Iwanowycz S, Wang J, Saaoud F, Yu F, Wang Y, Hu J, Chatterjee S, Wang Q, Fan D (2014) Emodin attenuates systemic and liver inflammation in hyperlipidemic mice administrated with lipopolysaccharides. Exp Biol Med 239(8):1025–1035CrossRef
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Zurück zum Zitat Kim JE, Son JE, Jang YJ, Lee DE, Kang NJ, Jung SK, Heo YS, Lee KW, Lee HJ (2011) Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/threonine kinase, inhibits tumor necrosis factor-alpha-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells. J Pharmacol Exp Ther 338(3):1013–1022. https://doi.org/10.1124/jpet.111.179200CrossRefPubMed Kim JE, Son JE, Jang YJ, Lee DE, Kang NJ, Jung SK, Heo YS, Lee KW, Lee HJ (2011) Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/threonine kinase, inhibits tumor necrosis factor-alpha-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells. J Pharmacol Exp Ther 338(3):1013–1022. https://​doi.​org/​10.​1124/​jpet.​111.​179200CrossRefPubMed
Zurück zum Zitat Kim M, Choi SY, Kim KT, Rhee YK, Hur J (2017) Ginsenoside Rg18 suppresses lipopolysaccharide-induced neuroinflammation in BV2 microglia and amyloid-β-induced oxidative stress in SH-SY5Y neurons via nuclear factor erythroid 2-related factor 2/heme oxygenase-1 induction. J Funct Foods 31:71–78CrossRef Kim M, Choi SY, Kim KT, Rhee YK, Hur J (2017) Ginsenoside Rg18 suppresses lipopolysaccharide-induced neuroinflammation in BV2 microglia and amyloid-β-induced oxidative stress in SH-SY5Y neurons via nuclear factor erythroid 2-related factor 2/heme oxygenase-1 induction. J Funct Foods 31:71–78CrossRef
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Zurück zum Zitat Liu N, Feng X, Wang W, Zhao X, Li X (2017) Paeonol protects against TNF-α-induced proliferation and cytokine release of rheumatoid arthritis fibroblast-like synoviocytes by upregulating FOXO3 through inhibition of miR-155 expression. Inflamm Res off J Eur Histamine Res Soc 66(7):603–610. https://doi.org/10.1007/s00011-017-1041-7CrossRef Liu N, Feng X, Wang W, Zhao X, Li X (2017) Paeonol protects against TNF-α-induced proliferation and cytokine release of rheumatoid arthritis fibroblast-like synoviocytes by upregulating FOXO3 through inhibition of miR-155 expression. Inflamm Res off J Eur Histamine Res Soc 66(7):603–610. https://​doi.​org/​10.​1007/​s00011-017-1041-7CrossRef
Zurück zum Zitat Lu X, Gong S, Wang X, Hu N, Pu D, Zhang J, Wang Y, Luo J, An Q, Ju B, He L (2021) Celastrol exerts cardioprotective effect in rheumatoid arthritis by inhibiting TLR2/HMGB1 signaling pathway-mediated autophagy. Int Arch Allergy Immunol 182(12):1245–1254. https://doi.org/10.1159/000517185CrossRefPubMed Lu X, Gong S, Wang X, Hu N, Pu D, Zhang J, Wang Y, Luo J, An Q, Ju B, He L (2021) Celastrol exerts cardioprotective effect in rheumatoid arthritis by inhibiting TLR2/HMGB1 signaling pathway-mediated autophagy. Int Arch Allergy Immunol 182(12):1245–1254. https://​doi.​org/​10.​1159/​000517185CrossRefPubMed
Zurück zum Zitat Ma L, Mu Y, Zhang Z, Sun Q (2018) Eugenol promotes functional recovery and alleviates inflammation, oxidative stress, and neural apoptosis in a rat model of spinal cord injury. Restor Neurol Neurosci 36:1–10 Ma L, Mu Y, Zhang Z, Sun Q (2018) Eugenol promotes functional recovery and alleviates inflammation, oxidative stress, and neural apoptosis in a rat model of spinal cord injury. Restor Neurol Neurosci 36:1–10
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Zurück zum Zitat Macaluso FS, Orlando A, Papi C, Festa S, Pugliese D, Bonovas S, Pansieri C, Piovani D, Fiorino G, Fantini MC, Caprioli F, Daperno M, Armuzzi A (2022) Use of biologics and small molecule drugs for the management of moderate to severe ulcerative colitis: IG-IBD clinical guidelines based on the GRADE methodology. Dig Liver Dis 54(4):440–451. https://doi.org/10.1016/j.dld.2022.01.127CrossRefPubMed Macaluso FS, Orlando A, Papi C, Festa S, Pugliese D, Bonovas S, Pansieri C, Piovani D, Fiorino G, Fantini MC, Caprioli F, Daperno M, Armuzzi A (2022) Use of biologics and small molecule drugs for the management of moderate to severe ulcerative colitis: IG-IBD clinical guidelines based on the GRADE methodology. Dig Liver Dis 54(4):440–451. https://​doi.​org/​10.​1016/​j.​dld.​2022.​01.​127CrossRefPubMed
Zurück zum Zitat Nallathamby N, Guanserm L, Vidyadaran S, Malek SNA, Raman J, Sabaratnam V (2015) Ergosterol of Cordyceps militaris attenuates LPS induced inflammation in BV2 microglia cells. Nat Prod Commun 10(6):885–886PubMed Nallathamby N, Guanserm L, Vidyadaran S, Malek SNA, Raman J, Sabaratnam V (2015) Ergosterol of Cordyceps militaris attenuates LPS induced inflammation in BV2 microglia cells. Nat Prod Commun 10(6):885–886PubMed
Zurück zum Zitat Nicholls SJ, Puri R, Anderson T, Ballantyne CM, Cho L, Kastelein JJ, Koenig W, Somaratne R, Kassahun H, Yang J, Wasserman SM, Scott R, Ungi I, Podolec J, Ophuis AO, Cornel JH, Borgman M, Brennan DM, Nissen SE (2016) Effect of evolocumab on progression of coronary disease in statin-treated patients: the GLAGOV randomized clinical trial. JAMA 316(22):2373–2384. https://doi.org/10.1001/jama.2016.16951CrossRefPubMed Nicholls SJ, Puri R, Anderson T, Ballantyne CM, Cho L, Kastelein JJ, Koenig W, Somaratne R, Kassahun H, Yang J, Wasserman SM, Scott R, Ungi I, Podolec J, Ophuis AO, Cornel JH, Borgman M, Brennan DM, Nissen SE (2016) Effect of evolocumab on progression of coronary disease in statin-treated patients: the GLAGOV randomized clinical trial. JAMA 316(22):2373–2384. https://​doi.​org/​10.​1001/​jama.​2016.​16951CrossRefPubMed
Zurück zum Zitat Ohgami K, Shiratori K, Kotake S, Nishida T, Mizuki N, Yazawa K, Ohno S (2003) Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Invest Ophthalmol vis Sci 44(6):2694–2701CrossRefPubMed Ohgami K, Shiratori K, Kotake S, Nishida T, Mizuki N, Yazawa K, Ohno S (2003) Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Invest Ophthalmol vis Sci 44(6):2694–2701CrossRefPubMed
Zurück zum Zitat Park M, Kim SH, Lee HJ (2021) Ginsenoside Rh1 exerts neuroprotective effects by activating the PI3K/Akt pathway in amyloid-β induced SH-SY5Y cells. Appl Sci 11(12):5654CrossRef Park M, Kim SH, Lee HJ (2021) Ginsenoside Rh1 exerts neuroprotective effects by activating the PI3K/Akt pathway in amyloid-β induced SH-SY5Y cells. Appl Sci 11(12):5654CrossRef
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Zurück zum Zitat Peto R, Davies C, Godwin J, Gray R, Pan HC, Clarke M, Cutter D, Darby S, McGale P, Taylor C, Wang YC, Bergh J, Di Leo A, Albain K, Swain S, Piccart M, Pritchard K (2012) Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet 379(9814):432–444. https://doi.org/10.1016/s0140-6736(11)61625-5CrossRefPubMed Peto R, Davies C, Godwin J, Gray R, Pan HC, Clarke M, Cutter D, Darby S, McGale P, Taylor C, Wang YC, Bergh J, Di Leo A, Albain K, Swain S, Piccart M, Pritchard K (2012) Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet 379(9814):432–444. https://​doi.​org/​10.​1016/​s0140-6736(11)61625-5CrossRefPubMed
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Zurück zum Zitat Ravikumar A, Arumugam G, Periyanayagam S, Vijayashankar S (2014) Rutin rich Emblica officinalis Geart. fruit extract ameliorates inflammation in the pancreas of rats subjected to alcohol and cerulein administration. J Complem Integr Med 2014:1 Ravikumar A, Arumugam G, Periyanayagam S, Vijayashankar S (2014) Rutin rich Emblica officinalis Geart. fruit extract ameliorates inflammation in the pancreas of rats subjected to alcohol and cerulein administration. J Complem Integr Med 2014:1
Zurück zum Zitat Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ (2017) Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med 377(12):1119–1131. https://doi.org/10.1056/NEJMoa1707914CrossRefPubMed Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ (2017) Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med 377(12):1119–1131. https://​doi.​org/​10.​1056/​NEJMoa1707914CrossRefPubMed
Zurück zum Zitat Robinson JG, Farnier M, Krempf M, Bergeron J, Luc G, Averna M, Stroes ES, Langslet G, Raal FJ, El Shahawy M, Koren MJ, Lepor NE, Lorenzato C, Pordy R, Chaudhari U, Kastelein JJ (2015) Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med 372(16):1489–1499. https://doi.org/10.1056/NEJMoa1501031CrossRefPubMed Robinson JG, Farnier M, Krempf M, Bergeron J, Luc G, Averna M, Stroes ES, Langslet G, Raal FJ, El Shahawy M, Koren MJ, Lepor NE, Lorenzato C, Pordy R, Chaudhari U, Kastelein JJ (2015) Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med 372(16):1489–1499. https://​doi.​org/​10.​1056/​NEJMoa1501031CrossRefPubMed
Zurück zum Zitat Sands BE, Peyrin-Biroulet L, Kierkus J, Higgins PDR, Fischer M, Jairath V, Hirai F, D’Haens G, Belin RM, Miller D, Gomez-Valderas E, Naegeli AN, Tuttle JL, Pollack PF, Sandborn WJ (2022) Efficacy and safety of mirikizumab in a randomized phase 2 study of patients with Crohn’s disease. Gastroenterology 162(2):495–508. https://doi.org/10.1053/j.gastro.2021.10.050CrossRefPubMed Sands BE, Peyrin-Biroulet L, Kierkus J, Higgins PDR, Fischer M, Jairath V, Hirai F, D’Haens G, Belin RM, Miller D, Gomez-Valderas E, Naegeli AN, Tuttle JL, Pollack PF, Sandborn WJ (2022) Efficacy and safety of mirikizumab in a randomized phase 2 study of patients with Crohn’s disease. Gastroenterology 162(2):495–508. https://​doi.​org/​10.​1053/​j.​gastro.​2021.​10.​050CrossRefPubMed
Zurück zum Zitat Santos Araújo NJ, Pereira da Silva AR, Costa MDS, Pereira Silva CA, Sampaio de Freitas T, Oliveira de Sousa E, Barbosa Filho JM, Soares L, de Matos YM, Melo Coutinho HD, Andrade-Pinheiro JC (2023) Evaluation of the antibacterial activity of hecogenin acetate and its inhibitory potential of NorA and MepA efflux pumps from Staphylococcus aureus. Microb Pathog 174:105925. https://doi.org/10.1016/j.micpath.2022.105925CrossRefPubMed Santos Araújo NJ, Pereira da Silva AR, Costa MDS, Pereira Silva CA, Sampaio de Freitas T, Oliveira de Sousa E, Barbosa Filho JM, Soares L, de Matos YM, Melo Coutinho HD, Andrade-Pinheiro JC (2023) Evaluation of the antibacterial activity of hecogenin acetate and its inhibitory potential of NorA and MepA efflux pumps from Staphylococcus aureus. Microb Pathog 174:105925. https://​doi.​org/​10.​1016/​j.​micpath.​2022.​105925CrossRefPubMed
Zurück zum Zitat Santos Passos FR, Pereira EWM, Heimfarth L, Monteiro BS, Gomes B, de Carvalho YM, Siqueira-Lima PS, Melo Coutinho HD, de Souza A, Araújo A, da Silva G, Almeida JR, Barreto RSS, Picot L, Quintans-Júnior LJ, Quintans JSS (2021) Role of peripheral and central sensitization in the anti-hyperalgesic effect of hecogenin acetate, an acetylated sapogenin, complexed with β-cyclodextrin: Involvement of NFκB and p38 MAPK pathways. Neuropharmacology 186:108395. https://doi.org/10.1016/j.neuropharm.2020.108395CrossRefPubMed Santos Passos FR, Pereira EWM, Heimfarth L, Monteiro BS, Gomes B, de Carvalho YM, Siqueira-Lima PS, Melo Coutinho HD, de Souza A, Araújo A, da Silva G, Almeida JR, Barreto RSS, Picot L, Quintans-Júnior LJ, Quintans JSS (2021) Role of peripheral and central sensitization in the anti-hyperalgesic effect of hecogenin acetate, an acetylated sapogenin, complexed with β-cyclodextrin: Involvement of NFκB and p38 MAPK pathways. Neuropharmacology 186:108395. https://​doi.​org/​10.​1016/​j.​neuropharm.​2020.​108395CrossRefPubMed
Zurück zum Zitat Sengupta P, Agarwal A, Pogrebetskaya M, Roychoudhury S, Durairajanayagam D, Henkel R (2018) Role of Withania somnifera (Ashwagandha) in the management of male infertility. Reprod Biomed 1:S1472648317306259 Sengupta P, Agarwal A, Pogrebetskaya M, Roychoudhury S, Durairajanayagam D, Henkel R (2018) Role of Withania somnifera (Ashwagandha) in the management of male infertility. Reprod Biomed 1:S1472648317306259
Zurück zum Zitat Sharman MJ, Verdile G, Kirubakaran S, Parenti C, Singh A, Watt G, Karl T, Chang D, Li CG, Münch G (2019b) Targeting inflammatory pathways in Alzheimer’s disease: a focus on natural products and phytomedicines. CNS Drugs 2019:1 Sharman MJ, Verdile G, Kirubakaran S, Parenti C, Singh A, Watt G, Karl T, Chang D, Li CG, Münch G (2019b) Targeting inflammatory pathways in Alzheimer’s disease: a focus on natural products and phytomedicines. CNS Drugs 2019:1
Zurück zum Zitat Sheng Y, Wu T, Dai Y, Xu L, Zhong Y, Xue Y, Tian Y (2020a) 6-gingerol alleviates inflammatory injury in DSS-induced ulcerative colitis mice by regulating NF-κB signaling. Ann Palliat Med 9(4):1944–1952CrossRefPubMed Sheng Y, Wu T, Dai Y, Xu L, Zhong Y, Xue Y, Tian Y (2020a) 6-gingerol alleviates inflammatory injury in DSS-induced ulcerative colitis mice by regulating NF-κB signaling. Ann Palliat Med 9(4):1944–1952CrossRefPubMed
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Metadaten
Titel
Recent advances in anti-inflammatory active components and action mechanisms of natural medicines
verfasst von
Zhimin Wu
Tao Zhang
Xiaofei Ma
Shuai Guo
Qingqing Zhou
Arshad Zahoor
Ganzhen Deng
Publikationsdatum
10.11.2023
Verlag
Springer International Publishing
Erschienen in
Inflammopharmacology / Ausgabe 6/2023
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-023-01369-9

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