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Erschienen in: Digestive Diseases and Sciences 12/2017

06.11.2017 | Review

Recent Advances in the Pharmacological Management of Gastroesophageal Reflux Disease

verfasst von: Yu-Min Kung, Wen-Hung Hsu, Meng-Chieh Wu, Jiunn-Wei Wang, Chung-Jung Liu, Yu-Chung Su, Chao-Hung Kuo, Fu-Chen Kuo, Deng-Chyang Wu, Yao-Kuang Wang

Erschienen in: Digestive Diseases and Sciences | Ausgabe 12/2017

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Abstract

The management of proton pump inhibitor-refractory GERD (rGERD) is a challenge in clinical practice. Since up to one-third of patients with typical GERD symptoms (heartburn and/or acid regurgitation) are not satisfied with proton pump inhibitor (PPI) therapy, new drug development targeting different pathophysiologies of GERD is imperative. At present, no other drugs serve as a more potent acid suppression agent than PPIs. As an add-on therapy, histamine type-2 receptor antagonists, alginates, prokinetics and transient lower esophageal sphincter relaxation inhibitors have some impact on the subgroups of rGERD, but greater effectiveness and fewer adverse effects for widespread use are required. Visceral hypersensitivity also contributes to the perception of GERD symptoms, and neuromodulators including antidepressants play a role in this category. Esophageal pH-impedance monitoring helps to distinguish functional heartburn from true GERD, and psychologic medication and cognitive behavior therapy are further therapy options instead of PPIs.
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Metadaten
Titel
Recent Advances in the Pharmacological Management of Gastroesophageal Reflux Disease
verfasst von
Yu-Min Kung
Wen-Hung Hsu
Meng-Chieh Wu
Jiunn-Wei Wang
Chung-Jung Liu
Yu-Chung Su
Chao-Hung Kuo
Fu-Chen Kuo
Deng-Chyang Wu
Yao-Kuang Wang
Publikationsdatum
06.11.2017
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 12/2017
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-017-4830-5

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