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05.02.2018 | Original Article | Ausgabe 1/2018

Cancer Microenvironment 1/2018

Recovery of Immunoglobulin VJ Recombinations from Pancreatic Cancer Exome Files Strongly Correlates with Reduced Survival

Zeitschrift:
Cancer Microenvironment > Ausgabe 1/2018
Autoren:
Jacob C. Kinskey, Yaping N. Tu, Wei Lue Tong, John M. Yavorski, George Blanck
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s12307-018-0205-5) contains supplementary material, which is available to authorized users.

Key Points

• A very high level of lymphocyte infiltrate in pancreatic cancer, as evidenced by an immunogenomics approach.
• A clear Th2 character to the lymphocyte infiltrate.
• A significantly worse survival rate for pancreatic cancer patients with demonstrable immunoglobulin light chain recombinations detected in the microenvironment.

Abstract

We assessed pancreatic cancer, lymphocyte infiltrates with a computational genomics approach. We took advantage of tumor-specimen exome files available from the cancer genome atlas to mine T- and B-cell immune receptor recombinations, using highly efficient, scripted algorithms established in several previous reports. Surprisingly, the results indicated that pancreatic cancer exomes represent one of the highest level yields for immune receptor recombinations, significantly higher than two comparison cancers used in this study, head and neck and bladder cancer. In particular, pancreatic cancer exomes have very large numbers of immunoglobulin light chain recombinations, both with regard to number of samples characterized by recovery of such recombinations and with regard to numbers of recombination reads per sample. These results were consistent with B-cell biomarkers, which emphasized the Th2 nature of the pancreatic lymphocyte infiltrate. The tumor specimen exomes with B-cell immune receptor recombination reads represented a dramatically poor outcome, a result not detected with either the head and neck or bladder cancer datasets. The results presented here support the potential value of immunotherapies designed to engineer a Th2 to Th1 shift in treating certain forms of pancreatic cancer.

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Zusatzmaterial
ESM 1 (PDF 7143 kb)
12307_2018_205_MOESM1_ESM.pdf
Literatur
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