nach oben

Translational Stroke Research

Erschienen in:

08.01.2020 | Review Article

Recruiting Control Participants into Stroke Biomarker Studies

verfasst von: Matthew A. Edwardson, Stephen J. Fernandez

Erschienen in: Translational Stroke Research | Ausgabe 5/2020

Einloggen, um Zugang zu erhalten

Abstract

The number of scientists using –omics technologies to investigate biomarkers with the potential to gauge risk and aid in the diagnosis, treatment, and prognosis of stroke continues to rise, yet there are few resources to aid investigators in recruiting control participants. In this review, we describe two major strategies to match control participants to a stroke cohort-propensity score matching and one-to-one matching—including statistical approaches to gauge the balance between groups. We then explore the advantages and disadvantages of traditional recruitment methods including approaching spouses of enrolled stroke participants, direct recruitment from clinics, community outreach events, approaching retirement communities, and buying samples from a 3rd party vendor. Newer methods to identify controls by screening the electronic health record and using an online screening questionnaire are also described. Finally, we cover compensation for control participants and special considerations. The hope is that this review will serve as a roadmap whereby an investigator can successfully tailor their control recruitment strategy to the research question at hand and the local research environment. While this review is focused on blood-based biomarker studies, the principles will apply to investigators studying a broad range of biological materials.

Nur mit Berechtigung zugänglich

Lind L, Siegbahn A, Lindahl B, Stenemo M, Sundstrom J, Arnlov J. Discovery of new risk markers for ischemic stroke using a novel targeted proteomics chip. Stroke. 2015.

Sheth SA, Iavarone AT, Liebeskind DS, Won SJ, Swanson RA. Targeted lipid profiling discovers plasma biomarkers of acute brain injury. PLoS One. 2015;10(6):e0129735.PubMedPubMedCentral

Tang Y, Xu H, Du X, Lit L, Walker W, Lu A, et al. Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. J Cereb Blood Flow Metab. 2006;26(8):1089–102.PubMed

De Marchis GM, Dankowski T, Konig IR, Fladt J, Fluri F, Gensicke H, et al. A novel biomarker-based prognostic score in acute ischemic stroke: the CoRisk score. Neurology. 2019;92(13):e1517–e25.PubMed

Kamel H, Longstreth WT Jr, Tirschwell DL, Kronmal RA, Broderick JP, Palesch YY, et al. The AtRial cardiopathy and antithrombotic drugs in prevention after cryptogenic stroke randomized trial: rationale and methods. Int J Stroke: Off J Int Stroke Soc. 2019;14(2):207–14.

Amarenco P, Labreuche J, Lavallee P, Touboul PJ. Statins in stroke prevention and carotid atherosclerosis: systematic review and up-to-date meta-analysis. Stroke. 2004;35(12):2902–9.PubMed

Lutsep HL, Albers GW, DeCrespigny A, Kamat GN, Marks MP, Moseley ME. Clinical utility of diffusion-weighted magnetic resonance imaging in the assessment of ischemic stroke. Ann Neurol. 1997;41(5):574–80.PubMed

Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet. 1998;351(9113):1379–87.

Barnett HJ, Taylor DW, Eliasziw M, Fox AJ, Ferguson GG, Haynes RB, Rankin RN, Clagett GP, Hachinski VC, Sackett DL, Thorpe KE, Meldrum HE, Spence JD Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 1998;339(20):1415–1425.

10.

Edwardson MA, Zhong X, Fiandaca MS, Federoff HJ, Cheema AK, Dromerick AW. Plasma microRNA markers of upper limb recovery following human stroke. Sci Rep. 2018;8(1):12558.PubMedPubMedCentral

11.

Ioannidis JP, Khoury MJ. Improving validation practices in “omics” research. Science. 2011;334(6060):1230–2.PubMedPubMedCentral

12.

Sun D, Tiedt S, Yu B, Jian X, Gottesman RF, Mosley TH, et al. A prospective study of serum metabolites and risk of ischemic stroke. Neurology. 2019;92(16):e1890–e8.PubMedPubMedCentral

13.

Edwardson MA, Ding L, Park C, Lane CJ, Nelsen MA, Wolf SL, et al. Reduced upper limb recovery in subcortical stroke patients with small prior radiographic stroke. Front Neurol. 2019;10:454.PubMedPubMedCentral

14.

Sharma S, Eghbali M. Influence of sex differences on microRNA gene regulation in disease. Biol Sex Differ. 2014;5(1):3.PubMedPubMedCentral

15.

Sacco RL, Boden-Albala B, Gan R, Chen X, Kargman DE, Shea S, et al. Stroke incidence among white, black, and Hispanic residents of an urban community: the northern Manhattan stroke study. Am J Epidemiol. 1998;147(3):259–68.PubMed

16.

Kleindorfer DO, Khoury J, Moomaw CJ, Alwell K, Woo D, Flaherty ML, et al. Stroke incidence is decreasing in whites but not in blacks: a population-based estimate of temporal trends in stroke incidence from the Greater Cincinnati/Northern Kentucky Stroke Study. Stroke. 2010;41(7):1326–31.PubMedPubMedCentral

17.

Carty CL, Keene KL, Cheng YC, Meschia JF, Chen WM, Nalls M, et al. Meta-analysis of genome-wide association studies identifies genetic risk factors for stroke in African Americans. Stroke. 2015;46(8):2063–8.PubMedPubMedCentral

18.

Kleindorfer DO, Lindsell C, Broderick J, Flaherty ML, Woo D, Alwell K, et al. Impact of socioeconomic status on stroke incidence: a population-based study. Ann Neurol. 2006;60(4):480–4.PubMed

19.

Merwick A, Albers GW, Arsava EM, Ay H, Calvet D, Coutts SB, et al. Reduction in early stroke risk in carotid stenosis with transient ischemic attack associated with statin treatment. Stroke. 2013;44(10):2814–20.PubMed

20.

Deb S, Austin PC, Tu JV, Ko DT, Mazer CD, Kiss A, et al. A review of propensity-score methods and their use in cardiovascular research. Can J Cardiol. 2016;32(2):259–65.PubMed

21.

Dykstra-Aiello C, Jickling GC, Ander BP, Shroff N, Zhan X, Liu D, et al. Altered expression of long noncoding RNAs in blood after ischemic stroke and proximity to putative stroke risk loci. Stroke. 2016;47(12):2896–903.PubMedPubMedCentral

22.

Ho DE, Imai K, King G, Stuart EA. Matching as nonparametric preprocessing for reducing model dependence in parametric causal inference. Polit Anal. 2007;15(3):199–236.

23.

Austin PC. Primer on statistical interpretation or methods report card on propensity-score matching in the cardiology literature from 2004 to 2006: a systematic review. Circ Cardiovasc Qual Outcomes. 2008;1(1):62–7.PubMed

24.

Rosenbaum PR, Rubin DB. The central role of the propensity score in observational studies for causal effects. Biometrika. 1983;70(1):41–5.

25.

Palesch YY. Some common misperceptions about P values. Stroke. 2014;45(12):e244–6.PubMedPubMedCentral

26.

Austin PC. Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Stat Med. 2009;28(25):3083–107.PubMedPubMedCentral

27.

Heijboer RRO, Lubberts B, Guss D, Johnson AH, Moon DK, DiGiovanni CW. Venous thromboembolism and bleeding adverse events in lower leg, ankle, and foot orthopaedic surgery with and without anticoagulants. J Bone Joint Surg Am. 2019;101(6):539–46.PubMed

28.

Normand ST, Landrum MB, Guadagnoli E, Ayanian JZ, Ryan TJ, Cleary PD, et al. Validating recommendations for coronary angiography following acute myocardial infarction in the elderly: a matched analysis using propensity scores. J Clin Epidemiol. 2001;54(4):387–98.PubMed

29.

Merino JG, Luby M, Benson RT, Davis LA, Hsia AW, Latour LL, et al. Predictors of acute stroke mimics in 8187 patients referred to a stroke service. J Stroke Cerebrovasc Dis. 2013;22(8):e397–403.PubMed

30.

Sharma R, Macy S, Richardson K, Lokhnygina Y, Laskowitz DT. A blood-based biomarker panel to detect acute stroke. J Stroke Cerebrovasc Dis. 2014;23(5):910–8.PubMed

31.

Lee SY, Choi YC, Kim JH, Kim WJ. Serum neuron-specific enolase level as a biomarker in differential diagnosis of seizure and syncope. J Neurol. 2010;257(10):1708–12.PubMed

32.

Selmaj I, Cichalewska M, Namiecinska M, Galazka G, Horzelski W, Selmaj KW, et al. Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis. Ann Neurol. 2017;81(5):703–17.PubMed

33.

Sun J, Cheng W, Liu L, Tao S, Xia Z, Qi L, et al. Identification of serum miRNAs differentially expressed in human epilepsy at seizure onset and post-seizure. Mol Med Rep. 2016;14(6):5318–24.PubMed

34.

Gargalas S, Weeks R, Khan-Bourne N, Shotbolt P, Simblett S, Ashraf L, et al. Incidence and outcome of functional stroke mimics admitted to a hyperacute stroke unit. J Neurol Neurosurg Psychiatry. 2017;88(1):2–6.PubMed

35.

Geisler F, Ali SF, Ebinger M, Kunz A, Rozanski M, Waldschmidt C, et al. Evaluation of a score for the prehospital distinction between cerebrovascular disease and stroke mimic patients. Int J Stroke Soc. 2018;1747493018806194.

36.

Lewandowski C, Mays-Wilson K, Miller J, Penstone P, Miller DJ, Bakoulas K, et al. Safety and outcomes in stroke mimics after intravenous tissue plasminogen activator administration: a single-center experience. J Stroke Cerebrovasc Dis. 2015;24(1):48–52.PubMed

37.

Markowitz J, Abrams Z, Jacob NK, Zhang X, Hassani JN, Latchana N, et al. MicroRNA profiling of patient plasma for clinical trials using bioinformatics and biostatistical approaches. Onco Targets Ther. 2016;9:5931–41.PubMedPubMedCentral

38.

Drake BF, Boyd D, Carter K, Gehlert S, Thompson VS. Barriers and strategies to participation in tissue research among African-American men. J Cancer Educ. 2017;32(1):51–8.PubMedPubMedCentral

39.

Freimuth VS, Quinn SC, Thomas SB, Cole G, Zook E, Duncan T. African Americans’ views on research and the Tuskegee syphilis study. Soc Sci Med. 2001;52(5):797–808.PubMed

40.

Corbie-Smith G. The continuing legacy of the Tuskegee syphilis study: considerations for clinical investigation. Am J Med Sci. 1999;317(1):5–8.PubMed

41.

Skloot R. The immortal life of Henrietta Lacks. Crown; 2010.

42.

Zhou Y, Elashoff D, Kremen S, Teng E, Karlawish J, Grill JD. African Americans are less likely to enroll in preclinical Alzheimer’s disease clinical trials. Alzheimers Dement. 2017;3(1):57–64.

43.

Braunstein JB, Sherber NS, Schulman SP, Ding EL, Powe NR. Race, medical researcher distrust, perceived harm, and willingness to participate in cardiovascular prevention trials. Medicine (Baltimore). 2008;87(1):1–9.

44.

Cottler LB, Zipp JF, Robins LN, Spitznagel EL. Difficult-to-recruit respondents and their effect on prevalence estimates in an epidemiologic survey. Am J Epidemiol. 1987;125(2):329–39.PubMed

45.

Jancey J, Howat P, Lee A, Clarke A, Shilton T, Fisher J, et al. Effective recruitment and retention of older adults in physical activity research: PALS study. Am J Health Behav. 2006;30(6):626–35.PubMed

46.

Amarenco P, Bogousslavsky J, Callahan A 3rd, Goldstein LB, Hennerici M, Rudolph AE, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med. 2006;355(6):549–59.PubMed

Titel: Recruiting Control Participants into Stroke Biomarker Studies
verfasst von: Matthew A. Edwardson
Stephen J. Fernandez
Publikationsdatum: 08.01.2020
Verlag: Springer US
Erschienen in: Translational Stroke Research / Ausgabe 5/2020
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-020-00780-6

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2020

Low Hemoglobin Levels at Admission Are Independently Associated with Cognitive Impairment after Ischemic Stroke: a Multicenter, Population-Based Study

Clot Analog Attenuation in Non-contrast CT Predicts Histology: an Experimental Study Using Machine Learning

Methylprednisolone Reduces Persistent Post-ischemic Inflammation in a Rat Hypoxia-Ischemia Model of Perinatal Stroke

Glycyrrhizin Prevents Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke with Delayed Thrombolysis Through Targeting Peroxynitrite-Mediated HMGB1 Signaling

ACOX3 Dysfunction as a Potential Cause of Recurrent Spontaneous Vasospasm of Internal Carotid Artery