Rediscovering FISH in the midst of a sperm chromatin conundrum

Excerpt

As much as we reach for solutions to the ART dilemma of selecting “good stuff,” the natural world’s predilection for shades of gray continues to stymie our hopes for a yes/no (sic binary) type of answer. Take for instance the question I often receive from patients and practitioners alike regarding how to choose the best oocyte. The answer is I have no clue. This response is all that can be mustered despite the fact that for many experienced oologists, including authors of well-known atlases of human oocyte morphology, sorting out the grossest of dysmorphisms has done little to improve our ability to choose the best oocyte in any way that might predictably aid in determining outcomes of import. In the end, what our selection strategies do is offer a best guess. …