nach oben

European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.11.2003 | Original Article

Regional differences between ^99mTc-ECD and ^99mTc-HMPAO SPET in perfusion changes with age and gender in healthy adults

verfasst von: Kentaro Inoue, Manabu Nakagawa, Ryoi Goto, Shigeo Kinomura, Tachio Sato, Kazunori Sato, Hiroshi Fukuda

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 11/2003

Einloggen, um Zugang zu erhalten

Abstract

A number of studies using single-photon emission tomography (SPET) have shown perfusion changes with age in several cortical and subcortical areas, which might distort the results of perfusion imaging studies of neuropsychiatric disorders. Technetium-99m labelled ethyl cysteinate dimer (ECD) and hexamethylpropylene amine oxime (HMPAO) are both used as markers of cerebral perfusion, but have different pharmacokinetics and retention patterns. The aim of this study was to determine whether age and gender effects on perfusion SPET differ depending on whether ^99mTc-HMPAO or ^99mTc-ECD is used. Forty-five subjects (20 male and 25 female, mean age 52.8±6.6 years) were assigned to ^99mTc-HMPAO SPET (HMPAO group), and 39 subjects (24 male and 15 female, mean age 52.6±6.7 years) to ^99mTc-ECD SPET (ECD group). SPET images were obtained about 10 min after intravenous injection of approximately 800 MBq ^99mTc-HMPAO or ^99mTc-ECD using the same SPET scanner. Three-dimensional volumetric magnetic resonance imaging was performed to as7sess morphological changes in the grey matter. All image processing and statistical analyses were performed using SPM99 software. An area in the right anterior frontal lobe showed an increase in perfusion with age only in the HMPAO group, whereas areas in the bilateral retrosplenial cortex showed decreases in perfusion with age only in the ECD group; neither group showed corresponding changes in the grey matter. The present study shows that different effects of age on perfusion are observed depending on whether ^99mTc-HMPAO and ^99mTc-ECD is used. This suggests that the results of perfusion SPET are differently confounded depending on the tracer used, and that perfusion SPET with these tracers has limitations when used in research on subtle perfusion changes.

Claus JJ, Breteler MM, Hasan D, Krenning EP, Bots ML, Grobbee DE, Van Swieten JC, Van Harskamp F, Hofman A. Regional cerebral blood flow and cerebrovascular risk factors in the elderly population. Neurobiol Aging 1998; 19:57–64.CrossRefPubMed

Goto R, Kawashima R, Ito H, Koyama M, Sato K, Ono S, Yoshioka S, Fukuda H. A comparison of Tc-99m HMPAO brain SPECT images of young and aged normal individuals. Ann Nucl Med 1998; 12:333–339.PubMed

Waldemar G, Hasselbalch SG, Andersen AR, Delecluse F, Petersen P, Johnsen A, Paulson OB.^99mTc-d,l-HMPAO and SPECT of the brain in normal aging. J Cereb Blood Flow Metab 1991; 11:508–521.PubMed

Pagani M, Salmaso D, Jonsson C, Hatherly R, Jacobsson H, Larsson SA, Wagner A. Regional cerebral blood flow as assessed by principal component analysis and^99mTc-HMPAO SPET in healthy subjects at rest: normal distribution and effect of age and gender. Eur J Nucl Med Mol Imaging 2002; 29:67–75.CrossRefPubMed

Van Laere K, Versijpt J, Audenaert K, Koole M, Goethals I, Achten E, Dierckx R.^99mTc-ECD brain perfusion SPET: variability, asymmetry and effects of age and gender in healthy adults. Eur J Nucl Med 2001; 28:873–887.PubMed

Matsuda H, Tsuji S, Shuke N, Sumiya H, Tonami N, Hisada K. Noninvasive measurements of regional cerebral blood flow using technetium-99m hexamethylpropylene amine oxime. Eur J Nucl Med 1993; 20:391–401.PubMed

Van Laere KJ, Dierckx RA. Brain perfusion SPECT: age- and sex-related effects correlated with voxel-based morphometric findings in healthy adults. Radiology 2001; 221:810–817.PubMed

Meltzer CC, Cantwell MN, Greer PJ, Ben-Eliezer D, Smith G, Frank G, Kaye WH, Houck PR, Price JC. Does cerebral blood flow decline in healthy aging? A PET study with partial-volume correction. J Nucl Med 2000; 41:1842–1848.PubMed

Leveille J, Demonceau G, Walovitch RC. Intrasubject comparison between technetium-99m-ECD and technetium-99m-HMPAO in healthy human subjects. J Nucl Med 1992; 33:480–484.PubMed

10.

Matsuda H, Li YM, Higashi S, Sumiya H, Tsuji S, Kinuya K, Hisada K, Yamashita J. Comparative SPECT study of stroke using Tc-99m ECD, I-123 IMP, and Tc-99m HMPAO. Clin Nucl Med 1993; 18:754–758.PubMed

11.

Pupi A, Castagnoli A, De Cristofaro MT, Bacciottini L, Petti AR. Quantitative comparison between^99mTc-HMPAO and ^99mTc-ECD: measurement of arterial input and brain retention. Eur J Nucl Med 1994; 21:124–130.PubMed

12.

Mozley PD, Sadek AM, Alavi A, Gur RC, Muenz LR, Bunow BJ, Kim HJ, Stecker MH, Jolles P, Newberg A. Effects of aging on the cerebral distribution of technetium-99m hexamethylpropylene amine oxime in healthy humans. Eur J Nucl Med 1997; 24:754–761.

13.

Larsson A, Skoog I, Aevarsson, Arlig A, Jacobsson L, Larsson L, Ostling S, Wikkelso C. Regional cerebral blood flow in normal individuals aged 40, 75 and 88 years studied by⁹⁹Tc^m-d,l-HMPAO SPET. Nucl Med Commun 2001; 22:741–746.CrossRefPubMed

14.

Jones K, Johnson KA, Becker JA, Spiers PA, Albert MS, Holman BL. Use of singular value decomposition to characterize age and gender differences in SPECT cerebral perfusion. J Nucl Med 1998; 39:965–973.PubMed

15.

Krausz Y, Bonne O, Gorfine M, Karger H, Lerer B, Chisin R. Age-related changes in brain perfusion of normal subjects detected by^99mTc-HMPAO SPECT. Neuroradiology 1998; 40:428–434.PubMed

16.

Ashburner J, Friston K. Multimodal image coregistration and partitioning -- a unified framework. Neuroimage 1997; 6:209–217.CrossRefPubMed

17.

Friston KJ, Ashburner J, Poline JB, Frith CD, Heather JD, Frackowiak RSJ. Spatial registration and normalization of images. Hum Brain Mapp 1995; 2:165–189.

18.

Hyun Y, Lee JS, Rha JH, Lee IK, Ha CK, Lee DS, Different uptake of^99mTc-ECD and ^99mTc-HMPAO in the same brains: analysis by statistical parametric mapping. Eur J Nucl Med 2001; 28:191–197.CrossRefPubMed

19.

Patterson JC, Early TS, Martin A, Walker MZ, Russell JM, Villanueva-Meyer H. SPECT image analysis using statistical parametric mapping: comparison of technetium-99m-HMPAO and technetium-99m-ECD. J Nucl Med 1997; 38:1721–1725.PubMed

20.

Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RSJ. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 2001; 14:21–36.CrossRefPubMed

21.

Ashburner J, Friston KJ. Voxel-based morphometry -- the methods. Neuroimage 2000; 11:805–821.CrossRefPubMed

22.

Ashburner J, Friston KJ. Nonlinear spatial normalization using basis functions. Hum Brain Mapp 1999; 7:254–266.CrossRefPubMed

23.

Koyama M, Kawashima R, Ito H, Ono S, Sato K, Goto R, Kinomura S, Yoshioka S, Sato T, Fukuda H. SPECT imaging of normal subjects with technetium-99m-HMPAO and technetium-99m-ECD. J Nucl Med 1997; 38:587–592.PubMed

24.

Catafau AM, Lomena FJ, Pavia J, Parellada E, Bernardo M, Setoain J, Tolosa E. Regional cerebral blood flow pattern in normal young and aged volunteers: a^99mTc-HMPAO SPET study. Eur J Nucl Med 1996; 23:1329–1337.PubMed

25.

Martin AJ, Friston KJ, Colebatch JG, Frackowiak RS. Decreases in regional cerebral blood flow with normal aging. J Cereb Blood Flow Metab 1991; 11:684–689.PubMed

26.

Leenders KL, Perani D, Lammertsma AA, et al., Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age. Brain 1990; 113 (Pt 1):27–47.

27.

Pantano P, Baron JC, Lebrun-Grandie P, Duquesnoy N, Bousser MG, Comar D. Regional cerebral blood flow and oxygen consumption in human aging. Stroke 1984; 15:635–641.PubMed

28.

Markus H, Ring H, Kouris K, Costa D. Alterations in regional cerebral blood flow, with increased temporal interhemispheric asymmetries, in the normal elderly: an HMPAO SPECT study. Nucl Med Commun 1993; 14:628–633.PubMed

29.

Leveille J, Demonceau G, De Roo M, Rigo P, Taillefer R, Morgan RA, Kupranick D, Walovitch RC. Characterization of technetium-99m-l,l-ECD for brain perfusion imaging. Part 2. Biodistribution and brain imaging in humans. J Nucl Med 1989; 30:1902–1910.PubMed

30.

Friberg L, Andersen AR, Lassen NA, Holm S, Dam M. Retention of^99mTc-bicisate in the human brain after intracarotid injection. J Cereb Blood Flow Metab 1994; 14 Suppl 1:S19–S27.

31.

Murphy DG, DeCarli C, McIntosh AR, Daly E, Mentis MJ, Pietrini P, Szczepanik J, Schapiro MB, Grady CL, Horwitz B, Rapoport SI. Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging. Arch Gen Psychiatry 1996; 53:585–594.PubMed

32.

Gur RC, Mozley PD, Resnick SM, et al. Gender differences in age effect on brain atrophy measured by magnetic resonance imaging. Proc Natl Acad Sci U S A 1991; 88:2845–2849.PubMed

33.

Good CD, Johnsrude I, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage 2001; 14:685–700.CrossRefPubMed

34.

Witelson S, Glezer I, Kigar D. Women have greater density of neurons in posterior temporal cortex. J Neurosci 1995; 15:3418–3428.PubMed

35.

Xu J, Kobayashi S, Yamaguchi S, Iijima K-i, Okada K, Yamashita K. Gender effects on age-related changes in brain structure. AJNR Am J Neuroradiol 2000; 21:112–118.PubMed

36.

Guttmann C, Jolesz F, Kikinis R, Killiany R, Moss M, Sandor T, Albert M. White matter changes with normal aging. Neurology 1998; 50:972–978.PubMed

37.

Blatter DD, Bigler ED, Gale SD, Johnson SC, Anderson CV, Burnett BM, Parker N, Kurth S, Horn SD. Quantitative volumetric analysis of brain MR: normative database spanning 5 decades of life. AJNR Am J Neuroradiol 1995; 16:241–251.PubMed

38.

Gur RC, Mozley LH, Mozley PD, Resnick SM, Karp JS, Alavi A, Arnold SE, Gur RE. Sex differences in regional cerebral glucose metabolism during a resting state. Science 1995; 267:528–531.PubMed

Titel: Regional differences between 99mTc-ECD and 99mTc-HMPAO SPET in perfusion changes with age and gender in healthy adults
verfasst von: Kentaro Inoue
Manabu Nakagawa
Ryoi Goto
Shigeo Kinomura
Tachio Sato
Kazunori Sato
Hiroshi Fukuda
Publikationsdatum: 01.11.2003
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 11/2003
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-003-1234-x

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2003

Comparison of [18F]FHBG and [14C]FIAU for imaging of HSV1-tk reporter gene expression: adenoviral infection vs stable transfection

Cost-effectiveness of FDG-PET in staging non-small cell lung cancer: the PLUS study

Regional cerebral blood flow assessed with 99mTc-ECD SPET as a marker of progression of mild cognitive impairment to Alzheimer's disease

Reduction of 99mTc-sestamibi and 99mTc-tetrofosmin uptake in MRP-expressing breast cancer cells under hypoxic conditions is independent of MRP function

Effect of attenuation correction on the interpretation of 99mTc-sestamibi myocardial perfusion scintigraphy: the impact of 1 year's experience

Radioiodinated SB 207710 as a radioligand in vivo: imaging of brain 5-HT4 receptors with SPET