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Erschienen in:
Open Access 01.12.2012 | Oral presentation
Regulation of immune cell responses by semaphorins and their receptors
Erschienen in: Arthritis Research & Therapy | Sonderheft 1/2012
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Semaphorins were originally identified as axon guidance factors involved in the development of the neuronal system. However, accumulating evidence indicates that several members of semaphorins, so-called 'immune semaphorins', are crucially involved in various phases of immune responses (Figure 1) [1‐3]. In addition, semaphorins and their receptors have been shown to be crucial for the pathogenesis of immunological disorders such as atopic dermatitis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis, These semaphorins regulate immune cell interactions during physiological and pathological immune responses. However, conventional static analysis could not determine definitively whether they regulate immune cell movement.
Figure 1
Semaphorins are involved in physiological and pathological immune responses.
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