Erschienen in:
01.09.2003 | Meeting abstract
Regulation of inflammatory CD28- T-helper cells by HLA class I molecules: a new cellular model for Behçet's disease?
verfasst von:
C Duftner, C Goldberger, E Märker-Hermann, M Schirmer
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 2/2003
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Excerpt
From immunogenetical studies we learnt that Behçet's disease (BD) is associated with HLA-B*51, and to a lesser extent with HLA-B*2702. There may even be a role of MICA genes in the pathogenesis of BD. Various of these MHC class I molecules can be recognized by NK receptors on NK and NK-T-cells independently from peptides. These NK cell receptors may be activating (DS) or inhibitory (DL). Interestingly, increased percentages of CD4+CD16+ and CD4+CD56+ T-cell subsets have already been described in BD patients. …