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01.12.2009 | Research | Ausgabe 1/2009 Open Access

Cardiovascular Ultrasound 1/2009

Relationship between carotid intima-media thickness and coronary angiographic findings: a prospective study

Cardiovascular Ultrasound > Ausgabe 1/2009
Ugur Coskun, Ahmet Yildiz, Ozlem B Esen, Murat Baskurt, Mehmet A Cakar, Kadriye O Kilickesmez, Lutfu A Orhan, Seyma Yildiz
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1476-7120-7-59) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

UC: Participated in performance of coronary angiograms, data analysis and drafting of the manuscript.
AY: Participated in performance and interpretation of coronary angiograms and drafting of the manuscript.
OBE: Participated in data collection, drafting and final revision of the manuscript.
MB: Participated in data collection and coordination of the study.
MAC: Performed the statistical analysis
KOK: Participated in data collection and coordination of the study.
LAO: Participated in data collection and coordination of the study.
SY: Performed the carotid Doppler examinations
All authors read and approved the final manuscript.



Since cardiovascular diseases are associated with high mortality and generally undiagnosed before the onset of clinical findings, there is a need for a reliable tool for early diagnosis. Carotid intima-media thickness (CIMT) is a non-invasive marker of coronary artery disease (CAD) and is widely used in practice as an inexpensive, reliable, and reproducible method. In the current study, we aimed to investigate prospectively the relationship of CIMT with the presence and extent of significant coronary artery narrowing in patients evaluated by coronary angiography for stable angina pectoris.


One hundred consecutive patients with stable angina pectoris and documented ischemia on a stress test were included in the study. The patients were divided into two groups according to the result of the coronary angiography: group 1 (39 patients) without a noncritical coronary lesion, and group 2 (61 patients) having at least one lesion more than 50% within the main branches of the coronary arteries. All of the patients underwent carotid Doppler ultrasound examination for measurement of the CIMT by a radiologist blinded to the angiographic data.


The mean CIMT was 0.78 ± 0.21 mm in Group 1, while it was 1.48 ± 0.28 mm in Group 2 (p = 0.001). The mean CIMT in patients with single vessel disease, multi-vessel disease, and left main coronary artery disease were significantly higher compared to Group 1 (1.2 ± 0.34 mm, p = 0.02; 1.6 ± 0.32 mm, p = 0.001; and 1.8 ± 0.31 mm, p = 0.0001, respectively). Logistic regression analysis identified CIMT (OR 4.3, p < 0.001) and hypertension (OR 2.4, p = 0.04) as the most important factors for predicting CAD.


The findings of this study show that increase in CIMT is associated with the presence and extent of CAD. In conclusion, we demonstrated the usefulness of carotid intima-media thickness in predicting coronary artery disease but large-scale studies are required to define its role in clinical practice.
Authors’ original file for figure 1
Authors’ original file for figure 2
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