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Erschienen in:
12.04.2020 | Brief Report
Relationship between faecal metronidazole and lactoferrin concentrations to clinical response of patients with Clostridioides difficile
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 9/2020
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Objectives
We investigated patients with Clostridioides difficile-associated diarrhoea to see if clinical resolution correlated with faecal concentrations of metronidazole or markers of inflammation.
Methods
Faecal metronidazole, lactoferrin and serum CRP were measured daily. These were then compared with clinical progress.
Results
Metronidazole concentration correlated with lactoferrin (ρ = 0.17, p = 0.015), CRP (ρ = 0.23, p < 0.001) and number of diarrhoeal stools per day (ρ = 0.29, p < 0.001). Lactoferrin correlated with CRP (ρ = 0.57, p < 0.001) and the number of diarrhoeal stools per day (ρ = 0.52, p < 0.001) as did CRP (ρ = 0.52, p < 0.001).
Conclusions
We found no association between cessation of diarrhoea and metronidazole or lactoferrin concentrations. There was a relationship between metronidazole concentrations and markers of inflammation and stool frequency.