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Targeted Oncology

Erschienen in:

01.06.2012 | Review

Relevance of angiogenesis in neuroendocrine tumors

verfasst von: Alexandre Teulé, Oriol Casanovas

Erschienen in: Targeted Oncology | Ausgabe 2/2012

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Abstract

While traditional cytotoxic drugs have shown limited efficacy in neuroendocrine tumors (NETs), their biological features have been characterized and can be exploited therapeutically. Their most prominent trait is an extraordinary vascularization in low-grade NETs and an hypoxia-dependent angiogenesis in high-grade NETs, which is associated to a significant expression of many proangiogenic molecules. Therefore, several antiangiogenic compounds have been tested in these malignancies, and among these, sunitinib has demonstrated activity in pancreatic NET patients by dually targeting the VEGFR and PDGFR pathways. In spite of these efficacious clinical results, apparent resistance to antiangiogenic therapies has been described in NET animal models and in clinical trials. Therefore, overcoming antiangiogenic resistance is a crucial step in the subsequent development of antiangiogenic therapies. Several strategies have been postulated to fight resistance, but preclinical studies and clinical trials will investigate and address these therapeutic approaches in the coming years in order to overcome resistance to antiangiogenic therapies in NETs.

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Titel: Relevance of angiogenesis in neuroendocrine tumors
verfasst von: Alexandre Teulé
Oriol Casanovas
Publikationsdatum: 01.06.2012
Verlag: Springer-Verlag
Erschienen in: Targeted Oncology / Ausgabe 2/2012
Print ISSN: 1776-2596
Elektronische ISSN: 1776-260X
DOI: https://doi.org/10.1007/s11523-012-0217-x

Springer Medizin

Relevance of angiogenesis in neuroendocrine tumors

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