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Targeted Oncology

Targeted Oncology OnlineFirst articles

08.03.2018 | Review Article

Targeting BCL-2 in Hematologic Malignancies

Resistance to apoptosis is one of the hallmarks of cancer and members of the B-cell lymphoma 2 (BCL-2) family of proteins are central regulators of apoptosis. Many cancers become resistant to chemotherapy and apoptosis by up-regulating BCL-2 and …

28.02.2018 | Original Research Article Open Access

Cabozantinib Versus Standard-of-Care Comparators in the Treatment of Advanced/Metastatic Renal Cell Carcinoma in Treatment-naïve Patients: a Systematic Review and Network Meta-Analysis

Renal cell carcinoma (RCC) is the most common type of kidney cancer and accounts for 2–3% of cancers worldwide [ 1 ]. The incidence is highest among men (twice over women’s rate [ 2 ]) and is increasing in many countries [ 3 ]. Individuals affected …

22.02.2018 | Leading Article

The Abscopal Effect in the Era of Cancer Immunotherapy: a Spontaneous Synergism Boosting Anti-tumor Immunity?

Radiotherapy is one of the main treatment strategies used in cancer. Aside from the local control of the disease, which is mediated by a direct cytotoxic effect on tumor cells, radiotherapy has also been shown to exert immune-mediated local and …

13.02.2018 | Original Research Article

Combining Ibrutinib with Chk1 Inhibitors Synergistically Targets Mantle Cell Lymphoma Cell Lines

Mantle cell lymphoma (MCL) is a rare, aggressive B cell lymphoma with an unfavorable clinical course and a median overall survival of 4-5 years. Since MCL is not curable with current therapies, new therapeutic strategies are urgently needed. Cell …

08.02.2018 | Review Article

Alpha-Emitters and Targeted Alpha Therapy in Oncology: from Basic Science to Clinical Investigations

Alpha-emitters are radionuclides that decay through the emission of high linear energy transfer α-particles and possess favorable pharmacologic profiles for cancer treatment. When coupled with monoclonal antibodies, peptides, small molecules, or …

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