Introduction
Methodology
Study Design
Patients
Control Group
Questionnaires
The Local Questionnaire
The HARQ-S
Within the last month, how did the following problems affect you? (0 = no problem and 5 = severe/frequent problem) | ||||||
---|---|---|---|---|---|---|
Hoarseness or a problem with your voice | 0 | 1 | 2 | 3 | 4 | 5 |
Clearing your throat | 0 | 1 | 2 | 3 | 4 | 5 |
Excess mucus in the throat, or drip down the back of your nose | 0 | 1 | 2 | 3 | 4 | 5 |
Retching or vomiting when you cough | 0 | 1 | 2 | 3 | 4 | 5 |
Cough on first lying down or bending over | 0 | 1 | 2 | 3 | 4 | 5 |
Chest tightness or wheeze when coughing | 0 | 1 | 2 | 3 | 4 | 5 |
Heartburn, indigestion, stomach acid coming up (or do you take medications for this, if yes score 5) | 0 | 1 | 2 | 3 | 4 | 5 |
A tickle in your throat, or a lump in your throat | 0 | 1 | 2 | 3 | 4 | 5 |
Cough with eating (during or soon after meals) | 0 | 1 | 2 | 3 | 4 | 5 |
Cough with certain foods | 0 | 1 | 2 | 3 | 4 | 5 |
Cough when you get out of bed in the morning | 0 | 1 | 2 | 3 | 4 | 5 |
Cough brought on by singing or speaking (for example, on the telephone) | 0 | 1 | 2 | 3 | 4 | 5 |
Coughing during the day rather than night | 0 | 1 | 2 | 3 | 4 | 5 |
A strange taste in your mouth | 0 | 1 | 2 | 3 | 4 | 5 |
Total score | 70 | – | – | – | – | – |
Statistical Methods
Instrumental Reliability
Concurrent Validity
Results
Participants
The HARQ-S
Psychometric Properties
Instrumental Reliability
Patients | Change from occasion 1 to occasion 2 | Controls | Change from occasion 1 to occasion 2 | |||||
---|---|---|---|---|---|---|---|---|
Item | Occasion 1 (n = 50) | Occasion 2 (n = 50) |
p value | Occasion 1 (n = 77) | Occasion 2 (n = 77) |
p value | ||
Hoarseness | ||||||||
0 | 14 (28 %) | 13 (26 %) | 67 (87 %) | 69 (89.6 %) | ||||
1 | 9 (18 %) | 7 (14 %) | 5 (6.5 %) | 6 (7.8 %) | ||||
2 | 1 (2 %) | 7 (14 %) | 4 (5.2 %) | 1 (1.3 %) | ||||
3 | 10 (20 %) | 8 (16 %) | Dec 14 (28 %) | 1 (1.3 %) | 1 (1.3 %) | Dec 4 (5.2 %) | ||
4 | 5 (10 %) | 8 (16 %) | Equ 25 (50 %) | Equ 72 (93.5 %) | ||||
5 | 11 (22 %) | 7 (14 %) | Inc 11 (22 %) | 0.69 | Inc 1 (1.3 %) | 0.38 | ||
Throat_cl | ||||||||
0 | 2 (4.1 %) | 6 (12.2 %) | 53 (68.8 %) | 52 (67.5 %) | ||||
1 | 4 (8.2 %) | 6 (12.2 %) | 17 (22.1 %) | 22 (28.6 %) | ||||
2 | 8 (16.3 %) | 6 (12.2 %) | 7 (9.1 %) | 3 (3.9 %) | ||||
3 | 12 (24.5 %) | 5 (10.2 %) | Dec 16 (32.7 %) | Dec 10 (13 %) | ||||
4 | 10 (20.4 %) | 12 (24.5 %) | Equ 20 (40.8 %) | Equ 58 (75.3 %) | ||||
5 | 13 (26.5 %) | 14 (28.6 %) | Inc 13 (26.5 %) | 0.71 | Inc 9 (11.7 %) | 1.00 | ||
Mucus | ||||||||
0 | 5 (10 %) | 8 (16 %) | 67 (87 %) | 65 (84.4 %) | ||||
1 | 7 (14 %) | 2 (4 %) | 7 (9.1 %) | 10 (13 %) | ||||
2 | 10 (20 %) | 9 (18 %) | 3 (3.9 %) | 2 (2.6 %) | ||||
3 | 9 (18 %) | 13 (26 %) | Dec 16 (32 %) | Dec 4 (5.2 %) | ||||
4 | 11 (22 %) | 9 (18 %) | Equ 16 (32 %) | Equ 67 (87 %) | ||||
5 | 8 (16 %) | 9 (18 %) | Inc 18 (36 %) | 0.86 | Inc 6 (7.8 %) | 0.75 | ||
Retching | ||||||||
0 | 18 (36 %) | 19 (38 %) | 75 (97.4 %) | 76 (98.7 %) | ||||
1 | 12 (24 %) | 15 (30 %) | 1 (1.3 %) | 1 (1.3 %) | ||||
2 | 4 (8 %) | 4 (8 %) | 1 (1.3 %) | 0 (0 %) | ||||
3 | 7 (14 %) | 5 (10 %) | Dec 17 (34 %) | Dec 2 (2.6 %) | ||||
4 | 4 (8 %) | 4 (8 %) | Equ 22 (44 %) | Equ 75 (97.4 %) | ||||
5 | 5 (10 %) | 3 (6 %) | Inc 11 (22 %) | 0.34 | Inc 0 (0 %) | 0.50 | ||
Lying down | ||||||||
0 | 15 (30 %) | 16 (32 %) | 75 (97.4 %) | 74 (96.1 %) | ||||
1 | 8 (16 %) | 6 (12 %) | 2 (2.6 %) | 2 (2.6 %) | ||||
2 | 12 (24 %) | 10 (20 %) | 0 (0 %) | 1 (1.3 %) | ||||
3 | 4 (8 %) | 8 (16 %) | Dec 12 (24 %) | Dec 2 (2.6 %) | ||||
4 | 1 (2 %) | 3 (6 %) | Equ 25 (50 %) | Equ 72 (93.5 %) | ||||
5 | 10 (20 %) | 7 (14 %) | Inc 13 (26 %) | 1.00 | Inc 3 (3.9 %) | 1.00 | ||
Wheeze | ||||||||
0 | 14 (28 %) | 17 (34 %) | 74 (96.1 %) | 77 (100 %) | ||||
1 | 9 (18 %) | 10 (20 %) | 3 (3.9 %) | 0 (0 %) | ||||
2 | 8 (16 %) | 5 (10 %) | ||||||
3 | 7 (14 %) | 8 (16 %) | Dec 15 (30 %) | Dec 3 (3.9 %) | ||||
4 | 9 (18 %) | 4 (8 %) | Equ 22 (44 %) | Equ 74 (96.1 %) | ||||
5 | 3 (6 %) | 6 (12 %) | Inc 13 (26 %) | 0.85 | Inc 0 (0 %) | 0.25 | ||
Heartburn | ||||||||
0 | 26 (52 %) | 21 (42 %) | 63 (81.8 %) | 61 (79.2 %) | ||||
1 | 4 (8 %) | 4 (8 %) | 5 (6.5 %) | 7 (9.1 %) | ||||
2 | 2 (4 %) | 6 (12 %) | 2 (2.6 %) | 3 (3.9 %) | ||||
3 | 4 (8 %) | 2 (4 %) | Dec 4 (8 %) | 1 (1.3 %) | 0 (0 %) | Dec 3 (3.9 %) | ||
4 | 2 (4 %) | 2 (4 %) | Equ 35 (70 %) | 0 (0 %) | 0 (0 %) | Equ 70 (90.9 %) | ||
5 | 12 (24 %) | 15 (30 %) | Inc 11 (22 %) | 0.12 | 6 (7.8 %) | 6 (7.8 %) | Inc 4 (5.2 %) | 1.00 |
Tickle | ||||||||
0 | 5 (10 %) | 12 (24 %) | 68 (88.3 %) | 74 (96.1 %) | ||||
1 | 11 (22 %) | 5 (10 %) | 7 (9.1 %) | 1 (1.3 %) | ||||
2 | 6 (12 %) | 7 (14 %) | 1 (1.3 %) | 1 (1.3 %) | ||||
3 | 6 (12 %) | 6 (12 %) | Dec 16 (32 %) | 1 (1.3 %) | 1 (1.3 %) | Dec 6 (7.8 %) | ||
4 | 9 (18 %) | 9 (18 %) | Equ 23 (46 %) | Equ 69 (89.6 %) | ||||
5 | 13 (26 %) | 11 (22 %) | Inc 11 (22 %) | 0.44 | Inc 2 (2.6 %) | 0.29 | ||
Eating | ||||||||
0 | 19 (38 %) | 17 (34 %) | 77 (100 %) | 77 (100 %) | ||||
1 | 6 (12 %) | 4 (8 %) | ||||||
2 | 5 (10 %) | 4 (8 %) | ||||||
3 | 5 (10 %) | 7 (14 %) | Dec 10 (20 %) | Dec 0 (0 %) | ||||
4 | 8 (16 %) | 9 (18 %) | Equ 24 (48 %) | Equ 77 (100 %) | ||||
5 | 7 (14 %) | 9 (18 %) | Inc 16 (32 %) | 0.33 | Inc 0 (0 %) | |||
Certain_foods | ||||||||
0 | 17 (34 %) | 17 (34 %) | 75 (97.4 %) | 75 (97.4 %) | ||||
1 | 7 (14 %) | 6 (12 %) | 1 (1.3 %) | 1 (1.3 %) | ||||
2 | 4 (8 %) | 4 (8 %) | 1 (1.3 %) | 1 (1.3 %) | ||||
3 | 6 (12 %) | 8 (16 %) | Dec 11 (22 %) | Dec 2 (2.6 %) | ||||
4 | 8 (16 %) | 9 (18 %) | Equ 27 (54 %) | Equ 74 (96.1 %) | ||||
5 | 8 (16 %) | 6 (12 %) | Inc 12 (24 %) | 1.00 | Inc 1 (1.3 %) | 1.00 | ||
Out_of_bed | ||||||||
0 | 15 (30 %) | 12 (24 %) | 73 (94.8 %) | 72 (93.5 %) | ||||
1 | 7 (14 %) | 7 (14 %) | 2 (2.6 %) | 3 (3.9 %) | ||||
2 | 5 (10 %) | 9 (18 %) | 2 (2.6 %) | 1 (1.3 %) | ||||
3 | 9 (18 %) | 9 (18 %) | Dec 9 (18 %) | 0 (0.0 %) | 1 (1.3 %) | Dec 2 (2.6 %) | ||
4 | 9 (18 %) | 8 (16 %) | Equ 26 (52 %) | Equ 73 (94.8 %) | ||||
5 | 5 (10 %) | 5 (10 %) | Inc 15 (30 %) | 0.31 | Inc 2 (2.6 %) | 1.00 | ||
Speaking | ||||||||
0 | 10 (20.0 %) | 9 (18.0 %) | 76 (98.7 %) | 75 (97.4 %) | ||||
1 | 2 (4.0 %) | 4 (8.0 %) | 1 (1.3 %) | 0 (0.0 %) | ||||
2 | 11 (22.0 %) | 8 (16.0 %) | 0 (0.0 %) | 0 (0.0 %) | ||||
3 | 8 (16.0 %) | 9 (18.0 %) | Dec 11 (22.0 %) | 0 (0.0 %) | 2 (2.6 %) | Dec 1 (1.3 %) | ||
4 | 10 (20.0 %) | 11 (22.0 %) | Equ 26 (52.0 %) | Equ 74 (96.1 %) | ||||
5 | 9 (18.0 %) | 9 (18.0 %) | Inc 13 (26.0 %) | 0.84 | Inc 2 (2.6 %) | 1.00 | ||
Day | ||||||||
0 | 5 (10 %) | 6 (12 %) | 75 (97.4 %) | 73 (94.8 %) | ||||
1 | 3 (6 %) | 5 (10 %) | 1 (1.3 %) | 1 (1.3 %) | ||||
2 | 6 (12 %) | 3 (6 %) | 1 (1.3 %) | 1 (1.3 %) | ||||
3 | 10 (20 %) | 7 (14 %) | Dec 15 (30 %) | 0 (0 %) | 1 (1.3 %) | Dec 1 (1.3 %) | ||
4 | 12 (24 %) | 11 (22 %) | Equ 19 (38 %) | 0 (0 %) | 0 (0 %) | Equ 72 (93.5 %) | ||
5 | 14 (28 %) | 18 (36 %) | Inc 16 (32 %) | 1.00 | 0 (0 %) | 1 (1.3 %) | Inc 4 (5.2 %) | 0.38 |
Taste | ||||||||
0 | 29 (58 %) | 27 (54 %) | 73 (94.8 %) | 75 (97.4 %) | ||||
1 | 6 (12 %) | 7 (14 %) | 2 (2.6 %) | 2 (2.6 %) | ||||
2 | 8 (16 %) | 3 (6 %) | 1 (1.3 %) | 0 (0 %) | ||||
3 | 2 (4 %) | 8 (16 %) | Dec 8 (16 %) | 0 (0 %) | 0 (0 %) | Dec 4 (5.2 %) | ||
4 | 1 (2 %) | 2 (4 %) | Equ 30 (60 %) | 1 (1.3 %) | 0 (0 %) | Equ 72 (93.5 %) | ||
5 | 4 (8 %) | 3 (6 %) | Inc 12 (24 %) | 0.50 | 0 (0 %) | 0 (0 %) | Inc 1 (1.3 %) | 0.38 |
Total score | 31.6 (13.0) | 31.7 (14.3) | 0.08 (8.1) | 1.9 (2.6) | 1.8 (3.5) | −0.08 (2.4) | ||
30.0 (4.0–64.0) | 33.0 (4.0–59.0) | −0.5 (−20.0–19.8) | 1.00 (0.0–11.0) | 0.0 (0.0–20.0) | −0.0 (−5.0–14.0) | |||
n = 50 |
n = 50 |
n = 50 | 0.96 |
n = 77 |
n = 77 |
n = 77 | 0.17 |
Item | wkappa (patients n = 50) | wkappa (controls n = 77) |
---|---|---|
Hoarseness | 0.60 (0.46–0.74) | 0.72 (0.47–0.96) |
Throat_clearing | 0.43 (0.25–0.62) | 0.51 (0.34–0.68) |
Mucus | 0.45 (0.30–0.59) | 0.54 (0.25–0.82) |
Retching | 0.53 (0.37–0.70) | 0.49 (0.15–0.84) |
Lying_down | 0.57 (0.41–0.73) | −0.03 (−0.05–0.00) |
Wheeze | 0.51 (0.34–0.67) | −0.00 (−0.00–−0.00) |
Heartburn | 0.73 (0.60–0.86) | 0.91 (0.83–0.98) |
Tickle | 0.54 (0.38–0.70) | 0.30 (0.06–0.54) |
Eating | 0.60 (0.45–0.74) | (–) |
Certain_foods | 0.59 (0.43–0.76) | 0.32 (−0.09–0.73) |
Out_of_bed | 0.65 (0.53–0.78) | 0.55 (0.16–0.94) |
Speaking | 0.64 (0.51–0.78) | −0.01 (−0.02–0.01) |
Day | 0.38 (0.20–0.56) | 0.27 (−0.15–0.69) |
Taste | 0.64 (0.49–0.80) | 0.18 (−0.14–0.50) |
Variable | Difference Occasion 2−Occasion 1 | Intraclass correlation coefficient (ICC) (95 % CI) | Intraindividual SD (IISD) | |
---|---|---|---|---|
Mean (95 % CI limits of agreement) (SD) median (range) | Systematic changes p value | |||
Total score (patients) (n = 50) | 0.076 (−15.847; 15.999) (8.124) −0.500 (−20.000–19.800) | 0.9584 | 0.83 (0.71; 0.90) | 5.69 |
Total score (controls) (n = 77) | −0.078 (−4.887; 4.731) (2.454) 0.000 (−5.000–14.000) | 0.1736 | 0.68 (0.54; 0.79) | 1.72 |