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Journal of Cancer Survivorship
Erschienen in: Journal of Cancer Survivorship 2/2019

17.04.2019 | Review

Reproductive outcomes following treatment for a gynecological cancer diagnosis: a systematic review

verfasst von: Brigitte Gerstl, Elizabeth Sullivan, Marcus Vallejo, Jana Koch, Maximilian Johnson, Handan Wand, Kate Webber, Angela Ives, Antoinette Anazodo

Erschienen in: Journal of Cancer Survivorship | Ausgabe 2/2019

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Abstract

Purpose

Fertility treatments are available for women diagnosed with a gynecological malignancy, which is important for women who desire a biological family subsequent to treatment. The objective of this study was to report reproductive outcomes following fertility-sparing treatment for a gynaecological cancer.

Methods

Electronic databases were searched to identify studies that reported on reproductive outcomes after treatment for a gynecological malignancy.

Results

In total, 77 studies were included which reported on reproductive outcomes after treatment for cervical cancer, endometrial cancer, gestational trophoblastic disease, and ovarian cancer. The main treatments included vaginal or abdominal radical trachelectomy, progestin therapy, salpingo-oophorectomy, and chemotherapy. The mean age at diagnosis for the study population and at birth were 30.5 years and 30.3 years, respectively. There were 4749 pregnancies (42%) reported for the included studies, with a miscarriage rate of 15% and a medical termination rate of 5%. The live birth rate was 74% with a 10% preterm rate.

Implications for Cancer Survivors

Patients should be offered timely discussions, information, and counseling regarding the impact of gynecological cancer treatment on a patient’s fertility. Furthermore, fertility-sparing strategies and fertility preservation should be discussed prior to starting treatment.
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Metadaten
Titel
Reproductive outcomes following treatment for a gynecological cancer diagnosis: a systematic review
verfasst von
Brigitte Gerstl
Elizabeth Sullivan
Marcus Vallejo
Jana Koch
Maximilian Johnson
Handan Wand
Kate Webber
Angela Ives
Antoinette Anazodo
Publikationsdatum
17.04.2019
Verlag
Springer US
Erschienen in
Journal of Cancer Survivorship / Ausgabe 2/2019
Print ISSN: 1932-2259
Elektronische ISSN: 1932-2267
DOI
https://doi.org/10.1007/s11764-019-00749-x

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