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Tumor Biology
Erschienen in: Tumor Biology 2/2016

23.12.2015 | Review

Research advances in HMGN5 and cancer

verfasst von: Zhan Shi, Run Tang, Ding Wu, Xiaoqing Sun

Erschienen in: Tumor Biology | Ausgabe 2/2016

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Abstract

High-mobility group nucleosome-binding domain 5 (HMGN5) is a new member of the high-mobility group N (HMGN) protein family that is involved in nucleosomal binding and transcriptional activation. It was first discovered in mouse, and recent studies found that the expressions of HMGN5 in many human cancers were also highly regulated, such as prostate, bladder, breast, and lung and clear cell renal cell carcinoma. Numerous reports have demonstrated that HMGN5 plays significant roles in many biological and pathological conditions, such as in developmental defects, hypersensitivity to stress, embryonic stem cell differentiation, and tumor progression. Importantly, deficiency of HMGN5 has been shown to be linked to cancer cell growth, cell cycle regulation, migration, invasion, and clinical outcomes, and it represents a promising therapeutic target for many malignant tumors. In the present review, we provide an overview of the current knowledge concerning the role of HMGN5 in cancer development and progression.
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Metadaten
Titel
Research advances in HMGN5 and cancer
verfasst von
Zhan Shi
Run Tang
Ding Wu
Xiaoqing Sun
Publikationsdatum
23.12.2015
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 2/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-4693-3

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