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European Journal of Nutrition

Erschienen in:

30.10.2020 | Original Contribution

Response of adult stem cell populations to a high-fat/high-fiber diet in skeletal muscle and adipose tissue of growing pigs divergently selected for feed efficiency

verfasst von: Marie-Hélène Perruchot, Frédéric Dessauge, Florence Gondret, Isabelle Louveau

Erschienen in: European Journal of Nutrition | Ausgabe 5/2021

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Abstract

Purpose

The control of body composition by genetics and dietary nutrients is of the upmost importance for both human and animal physiology. Adult stem cells (aSC) may represent a relevant level of tissue adaptation. The purpose of this study was to determine the impact of macronutrient composition on aSC populations isolated from adipose tissue or muscle in growing pigs.

Methods

Pigs from two lines divergently selected for feed efficiency were fed ad libitum either a high-fat/high-fiber (HF) diet or a low-fat/low-fiber (LF) diet (n = 6 per line and diet) from 74 to 132 days of age. Stroma vascular cells were isolated from adipose tissue and muscle and characterized with cell surface markers.

Results

In both lines, pigs fed the HF diet exhibited a reduced adiposity (P < 0.001) compared with pigs fed the LF diet. In the four groups, CD90 and PDGFRα markers were predominantly expressed in adipose cells, whereas CD90 and CD56 markers were highly expressed in muscle cells. In adipose tissue, the proportions of CD56+/PDGFRα + and of CD90+/PDGFRα + cells were lower (P < 0.05) in HF pigs than in LF pigs. On the opposite, in muscle, these proportions were higher (P < 0.001) in HF pigs.

Conclusion

This study indicates that dietary nutrients affected the relative proportions of CD56+/PDGFRα + cells with opposite effects between muscle and adipose tissue. These cell populations exhibiting adipogenic potential in adipose tissue and myogenic potential in muscle may be a target to modulate body composition.

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Hilton TN, Tuttle LJ, Bohnert KL, Mueller MJ, Sinacore DR (2008) Excessive adipose tissue infiltration in skeletal muscle in individuals with obesity, diabetes mellitus, and peripheral neuropathy: association with performance and function. Phys Ther 88:1336–1344. https://doi.org/10.2522/ptj.20080079CrossRefPubMedPubMedCentral

Sillence MN (2004) Technologies for the control of fat and lean deposition in livestock. Vet J 167:242–257. https://doi.org/10.1016/j.tvjl.2003.10.020CrossRefPubMed

Minguell JJ, Erices A, Conget P (2001) Mesenchymal stem cells. Exp Biol Med (Maywood) 226:507–520. https://doi.org/10.1177/153537020122600603CrossRef

Mihaylova MM, Sabatini DM, Yilmaz OH (2014) Dietary and metabolic control of stem cell function in physiology and cancer. Cell Stem Cell 14(3):292–305. https://doi.org/10.1016/j.stem.2014.02.008CrossRefPubMedPubMedCentral

Onate B, Vilahur G, Ferrer-Lorente R, Ybarra J, Diez-Caballero A, Ballesta-Lopez C, Moscatiello F, Herrero J, Badimon L (2012) The subcutaneous adipose tissue reservoir of functionally active stem cells is reduced in obese patients. FASEB J 26:4327–4336. https://doi.org/10.1096/fj.12-207217CrossRef

Perez LM, Bernal A, de Lucas B, San Martin N, Mastrangelo A, Garcia A, Barbas C, Galvez BG (2015) Altered metabolic and stemness capacity of adipose tissue-derived stem cells from obese mouse and human. PLoS ONE 10:e0123397. https://doi.org/10.1371/journal.pone.0123397CrossRefPubMedPubMedCentral

Tachtsis B, Camera D, Lacham-Kaplan O (2018) Potential roles of n – 3 PUFAs during skeletal muscle growth and regeneration. Nutrients 10:309. https://doi.org/10.3390/nu10030309CrossRefPubMedCentral

Cerletti M, Jang YC, Finley LW, Haigis MC, Wagers AJ (2012) Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell 10:515–519. https://doi.org/10.1016/j.stem.2012.04.002CrossRefPubMedPubMedCentral

Yan H, Potu R, Lu H, Vezzoni de Almeida V, Stewart T, Ragland D, Armstrong A, Adeola O, Nakatsu CH, Ajuwon KM (2013) Dietary fat content and fiber type modulate hind gut microbial community and metabolic markers in the pig. PLoS ONE 8:e59581. https://doi.org/10.1371/journal.pone.0059581CrossRefPubMedPubMedCentral

10.

Brockman DA, Chen X, Gallaher DD (2014) High-viscosity dietary fibers reduce adiposity and decrease hepatic steatosis in rats fed a high-fat diet. J Nutr 144:1415–1422. https://doi.org/10.3945/jn.114.191577CrossRefPubMed

11.

Gilbert H, Bidanel JP, Gruand J, Caritez JC, Billon Y, Guillouet P, Lagant H, Noblet J, Sellier P (2007) Genetic parameters for residual feed intake in growing pigs, with emphasis on genetic relationships with carcass and meat quality traits. J Anim Sci 85:3182–3188. https://doi.org/10.2527/jas.2006-590CrossRefPubMed

12.

Gondret F, Louveau I, Mourot J, Duclos MJ, Lagarrigue S, Gilbert H, van Milgen J (2014) Dietary energy sources affect the partition of body lipids and the hierarchy of energy metabolic pathways in growing pigs differing in feed efficiency. J Anim Sci 92:4865–4877. https://doi.org/10.2527/jas.2014-7995CrossRefPubMed

13.

Gondret F, Vincent A, Houee-Bigot M, Siegel A, Lagarrigue S, Louveau I, Causeur D (2016) Molecular alterations induced by a high-fat high-fiber diet in porcine adipose tissues: variations according to the anatomical fat location. BMC Genomics 17:120. https://doi.org/10.1186/s12864-016-2438-3CrossRefPubMedPubMedCentral

14.

Carninci P (2014) Genomics: mice in the ENCODE spotlight. Nature 515:346–347. https://doi.org/10.1038/515346aCrossRefPubMed

15.

Dodson MV, Hausman GJ, Guan L, Du M, Rasmussen TP, Poulos SP, Mir P, Bergen WG, Fernyhough ME, McFarland DC, Rhoads RP, Soret B, Reecy JM, Velleman SG, Jiang Z (2010) Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research. Int J Biol Sci 6:691–699. https://doi.org/10.7150/ijbs.6.691CrossRefPubMedPubMedCentral

16.

Litten-Brown JC, Corson AM, Clarke L (2010) Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview. Animal 4:899–920. https://doi.org/10.1017/S1751731110000200CrossRefPubMed

17.

Nielsen KL, Hartvigsen ML, Hedemann MS, Laerke HN, Hermansen K, Bach Knudsen KE (2014) Similar metabolic responses in pigs and humans to breads with different contents and compositions of dietary fibers: a metabolomics study. Am J Clin Nutr 99:941–949. https://doi.org/10.3945/ajcn.113.07472CrossRefPubMed

18.

De Clercq L, Mourot J, Genart C, Davidts V, Boone C, Remacle C (1997) An anti-adipocyte monoclonal antibody is cytotoxic to porcine preadipocytes in vitro and depresses the development of pig adipose tissue. J Anim Sci 75:1791–1797. https://doi.org/10.2527/1997.7571791xCrossRef

19.

Perruchot MH, Ecolan P, Sorensen IL, Oksbjerg N, Lefaucheur L (2012) In vitro characterization of proliferation and differentiation of pig satellite cells. Differentiation 84:322–329. https://doi.org/10.1016/j.diff.2012.08.001CrossRefPubMed

20.

Perruchot MH, Lefaucheur L, Barreau C, Casteilla L, Louveau I (2013) Age-related changes in the features of porcine adult stem cells isolated from adipose tissue and skeletal muscle. Am J Physiol Cell Physiol 305(7):C728–C738. https://doi.org/10.1152/ajpcell.00151.2013CrossRefPubMed

21.

Joe AW, Yi L, Natarajan A, Le Grand F, So L, Wang J, Rudnicki MA, Rossi FM (2010) Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat Cell Biol 12:153–163. https://doi.org/10.1038/ncb2015CrossRefPubMedPubMedCentral

22.

Uezumi A, Fukada S, Yamamoto N, Takeda S, Tsuchida K (2010) Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat Cell Biol 12:143–152. https://doi.org/10.1038/ncb2014CrossRefPubMed

23.

Uezumi A, Fukada S, Yamamoto N, Ikemoto-Uezumi M, Nakatani M, Morita M, Yamaguchi A, Yamada H, Nishino I, Hamada Y, Tsuchida K (2014) Identification and characterization of PDGFRalpha+ mesenchymal progenitors in human skeletal muscle. Cell Death Dis 5:e1186. https://doi.org/10.1038/cddis.2014.161CrossRefPubMedPubMedCentral

24.

Lee YH, Granneman JG (2012) Seeking the source of adipocytes in adult white adipose tissues. Adipocyte 1:230–236. https://doi.org/10.4161/adip.20804CrossRefPubMedPubMedCentral

25.

Lee YH, Petkova AP, Mottillo EP, Granneman JG (2012) In vivo identification of bipotential adipocyte progenitors recruited by beta3-adrenoceptor activation and high-fat feeding. Cell Metab 15:480–491. https://doi.org/10.1016/j.cmet.2012.03.009CrossRefPubMedPubMedCentral

26.

Arrighi N, Moratal C, Clement N, Giorgetti-Peraldi S, Peraldi P, Loubat A, Kurzenne JY, Dani C, Chopard A, Dechesne CA (2015) Characterization of adipocytes derived from fibro/adipogenic progenitors resident in human skeletal muscle. Cell Death Dis 6:e1733. https://doi.org/10.1038/cddis.2015.79CrossRefPubMedPubMedCentral

27.

Zimmerlin L, Donnenberg VS, Pfeifer ME, Meyer EM, Peault B, Rubin JP, Donnenberg AD (2010) Stromal vascular progenitors in adult human adipose tissue. Cytometry A 77:22–30. https://doi.org/10.1002/cyto.a.20813CrossRefPubMedPubMedCentral

28.

Pisani DF, Clement N, Loubat A, Plaisant M, Sacconi S, Kurzenne JY, Desnuelle C, Dani C, Dechesne CA (2010) Hierarchization of myogenic and adipogenic progenitors within human skeletal muscle. Stem Cells 28:2182–2194. https://doi.org/10.1002/stem.537CrossRefPubMed

29.

Iwayama T, Steele C, Yao L, Dozmorov MG, Karamichos D, Wren JD, Olson LE (2015) PDGFRalpha signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity. Genes Dev 29:1106–1119. https://doi.org/10.1101/gad.260554.115CrossRefPubMedPubMedCentral

30.

Capkovic KL, Stevenson S, Johnson MC, Thelen JJ, Cornelison DD (2008) Neural cell adhesion molecule (NCAM) marks adult myogenic cells committed to differentiation. Exp Cell Res 314:1553–1565. https://doi.org/10.1016/j.yexcr.2008.01.021CrossRefPubMedPubMedCentral

31.

Meln I, Wolff G, Gajek T, Koddebusch J, Lerch S, Harbrecht L, Hong W, Bayindir-Buchhalter I, Krunic D, Augustin HG, Vegiopoulos A (2019) Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth. Mol Metab 24:139–148. https://doi.org/10.1016/j.molmet.2019.03.012CrossRefPubMedPubMedCentral

32.

Silva KR, Baptista LS (2019) Adipose-derived stromal/stem cells from different adipose depots in obesity development. World J Stem Cells 11:147–166. https://doi.org/10.4252/wjsc.v11.i3.147CrossRefPubMedPubMedCentral

33.

Kulenkampff E, Wolfrum C (2018) Proliferation of nutrition sensing preadipocytes upon short term HFD feeding. Adipocyte:1–10. Adipocyte 8:16–25. https://doi.org/10.1080/21623945.2018.1521229CrossRefPubMedPubMedCentral

34.

Pincu Y, Huntsman HD, Zou K, De Lisio M, Mahmassani ZS, Munroe MR, Garg K, Jensen T, Boppart MD (2016) Diet-induced obesity regulates adipose-resident stromal cell quantity and extracellular matrix gene expression. Stem Cell Res 17:181–190. https://doi.org/10.1016/j.scr.2016.07.002CrossRefPubMed

35.

Fiorotto ML, Davis TA (2018) Critical windows for the programming effects of early-life nutrition on skeletal muscle mass. Nestle Nutr Inst Workshop Ser. 89:25–35. https://doi.org/10.1159/000486490CrossRefPubMedPubMedCentral

36.

Mostyn A, Symonds ME (2009) Early programming of adipose tissue function: a large-animal perspective. Proc Nutr Soc 68:393–400. https://doi.org/10.1017/S002966510999022XCrossRefPubMed

37.

Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB (2016) Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front Endocrinol (Lausanne) 7:30. https://doi.org/10.3389/fendo.2016.00030CrossRef

38.

Jang H, Kim M, Lee S, Kim J, Woo DC, Kim KW, Song K, Lee I (2016) Adipose tissue hyperplasia with enhanced adipocyte-derived stem cell activity in Tc1(C8orf4)-deleted mice. Sci Rep 6:35884. https://doi.org/10.1038/srep35884CrossRefPubMedPubMedCentral

39.

Girousse A, Gil-Ortega M, Bourlier V, Bergeaud C, Sastourne-Arrey Q, Moro C, Barreau C, Guissard C, Vion J, Arnaud E, Pradere JP, Juin N, Casteilla L, Sengenes C (2019) The release of adipose stromal cells from subcutaneous adipose tissue regulates ectopic intramuscular adipocyte deposition. Cell Rep 27:323–333. https://doi.org/10.1016/j.celrep.2019.03.038(e325)CrossRefPubMed

Titel: Response of adult stem cell populations to a high-fat/high-fiber diet in skeletal muscle and adipose tissue of growing pigs divergently selected for feed efficiency
verfasst von: Marie-Hélène Perruchot
Frédéric Dessauge
Florence Gondret
Isabelle Louveau
Publikationsdatum: 30.10.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 5/2021
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-020-02418-7

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