Background
Methods
Study design
Study population
Retinal arteriolar structure and retinal capillary flow
Retinal intercapillary distance and area
Statistical methods
Results
Study population
Short time hypertensive patients (n = 70) | Long time hypertensive patients (n = 64) | Healthy control subjects (n = 55) | ANOVA results p-value | ||
---|---|---|---|---|---|
Clinical characteristics | |||||
Age (years) | 52 ± 9.3 | 51 ± 13 | 53 ± 13 |
p = 0.585 | |
BMI (kg/m2) | 28.3 (25–31) | 27.8 (26–30) | 25.3 (23–29) |
p = 0.011
| |
Sex (male/female) | 46/24 | 53/11 | 19/36 |
p < 0.001
| |
Systolic Office BP (mmHg) | 146 ± 12 | 147 ± 11 | 124 ± 12 |
p < 0.001
| |
Diastolic Office BP (mmHg) | 90 ± 8.6 | 89 ± 9.1 | 79 ± 9.1 |
p < 0.001
| |
HR (bpm) | 73 ± 8.6 | 73 ± 7.9 | 70 ± 13 |
p = 0.739 | |
Systolic 24 h Ambulatory BP (mmHg) | 142 ± 10.2 | 148 ± 9.7 | 120 ± 9.6 |
p < 0.001
| |
Diastolic 24 h Ambulatory BP (mmHg) | 89 ± 9.4 | 92 ± 9.9 | 75 ± 4.1 |
p < 0.001
| |
Serum creatinine (mmol/L) | 0.077 ± 0.02 | 0.080 ± 0.01 | 0.073 ± 0.02 |
p = 0.013
| |
Cholesterol (mmol/L) | 5.75 ± 0.98 | 5.57 ± 0.98 | 6.16 ± 1.19 |
p < 0.001
| |
LDL (mmol/L) | 3.89 ± 0.96 | 3.76 ± 0.98 | 4.04 ± 0.93 |
p = 0.138 | |
HDL (mmol/L) | 1.39 ± 0.33 | 1.29 ± 0.27 | 1.63 ± 0.34 |
p < 0.001
| |
Plasma glucose (mmol/L) | 5.05 ± 0.54 | 5.11 ± 0.66 | 4.83 ± 0.93 |
p = 0.306 | |
Retinal parameters | |||||
Short time Hypertensive patient | Long time Hypertensive patients | Healthy control subjects |
p-value healthy vs hypertensive |
p-value healthy vs long time hypertensive | |
ICD (μm) | 22.2 ± 5.2 | 24.2 ± 6.3 | 20.1 ± 4.2 |
p = 0.001
|
p < 0.001
|
CapA (−) | 1643 ± 602 | 1462 ± 690 | 1821 ± 651 |
p = 0.013
|
p = 0.005
|
RCF (AU) | 299 ± 72 | 282 ± 70 | 314 ± 60 |
p = 0.032
|
p = 0.010
|
OD (μm) | 102 ± 12 | 102 ± 15 | 107 ± 11 |
p = 0.038
|
p = 0.052
|
ID (μm) | 76.1 ± 7.1 | 75.5 ± 8.5 | 79.6 ± 8.0 |
p = 0.004
|
p = 0.010
|
WT (μm) | 13.2 ± 3.7 | 13.2 ± 4.4 | 13.6 ± 3.8 |
p = 0.552 |
p = 0.614 |
WLR (−) | 0.345 ± 0.08 | 0.346 ± 0.10 | 0.352 ± 0.11 |
p = 0.693 |
p = 0.769 |
CA (μm [2]) | 3773 ± 1408 | 3806 ± 1698 | 3963 ± 1489 |
p = 0.540 |
p = 0.646 |
Retinal capillary density and retinal capillary flow
Retinal parameters | ||||||
---|---|---|---|---|---|---|
Short time Hypertensive | Long time Hypertensive | Healthy control subjects |
p-value model 1 |
p-value model 2 |
p-value model 3 | |
ICD (μm) | 22.2 ± 5.2 | 24.2 ± 6.3 | 20.1 ± 4.2 |
p = 0.011 |
p = 0.008 |
p = 0.035 |
CapA (−) | 1643 ± 602 | 1462 ± 690 | 1821 ± 651 |
p = 0.001 |
p = 0.001 |
p = 0.010 |
RCF (AU) | 299 ± 72 | 282 ± 70 | 314 ± 60 |
p = 0.010 |
p = 0.009 |
p = 0.071 |
Retinal capillary density and wall-to-lumen ratio
Adjustment for model 1 | |||
Total study population | Hypertensive patients | Healthy control subjects | |
ICD (μm) and WLR (−) |
r = 0.146 |
r = 0.192 |
r = −0.150 |
p = 0.060 |
p = 0.035 |
p = 0.343 | |
CapA (−) and WLR (−) |
r = −0.195 |
r = −0.189 |
r = −0.128 |
p = 0.011 |
p = 0.038 |
p = 0.419 | |
ICD (μm) and HDL (mmol/L) |
r = −0.187 |
r = −0.112 |
r = 0.010 |
p = 0.014 |
p = 0.278 |
p = 0.964 | |
CapA (−) and HDL (mmol/L) |
r = 0.156 |
r = 0.069 |
r = 0.027 |
p = 0.040 |
p = 0.502 |
p = 0.902 | |
Adjustment for model 2 | |||
Total study population | Hypertensive patients | Healthy control subjects | |
ICD (μm) and WLR (−) |
r = 0.192 |
r = 0.254 |
r = 0.027 |
p = 0.014 | p = 0.006 |
p = 0.873 | |
CapA (−) and WLR (−) |
r = −0.229 |
r = −0.276 |
r = −0.175 |
p = 0.003 |
p = 0.003 |
p = 0.293 | |
ICD (μm) and HDL (mmol/L) |
r = −0.172 |
r = −0.083 |
r = −0.032 |
p = 0.025 |
p = 0.428 |
p = 0.889 | |
CapA (−) and HDL (mmol/L) |
r = 0.148 |
r = 0.026 |
r = 0.098 |
p = 0.050 |
p = 0.803 |
p = 0.672 | |
ICD (μm) and systolic 24ABP |
r = 0.253 | ||
p = 0.009 | |||
ICD (μm) and diastolic 24ABP |
r = 0.190 | ||
p = 0.050 | |||
ICD (μm) and systolic OBP |
r = 0.143 | ||
p = 0.060 | |||
Adjustment for model 3 | |||
ICD (μm) and WLR (−) |
r = 0.227 |
r = 0.231 |
r = 0.133 |
p = 0.018 |
p = 0.032 |
p = 0.611 | |
CapA (−) and WLR (−) |
r = −0.256 |
r = −0.212 |
r = −0.431 |
p = 0.007 |
p = 0.048 |
p = 0.084 | |
ICD (μm) and HDL (mmol/L) |
r = −0.243 |
r = −0.210 |
r = −0.252 |
p = 0.011 |
p = 0.051 |
p = 0.329 | |
CapA (−) and HDL (mmol/L) |
r = 0.224 |
r = 0.148 |
r = 0.387 |
p = 0.020 |
p = 0.172 |
p = 0.125 |