Risk factors for community-acquired acute kidney injury in patients with and without chronic kidney injury and impact of its initial management on prognosis: a prospective observational study

Acute Kidney Injury (AKI) is a frequent disorder with an incidence of 400 per 100′000 persons per year in community-based populations [1]. AKI has been associated with increased mortality and progression to CKI [2], and there is increased awareness of its ominous long-term prognosis [3]. Most studies, however, have focused on hospital-acquired AKI (HA-AKI) and very few studies have analyzed the characteristics and outcomes of patients with community-acquired acute kidney injury (CA-AKI) despite its occurrence in 1% of hospital admissions [4, 5]. A prospective Spanish study demonstrated that 52% of AKI cases were HA-AKI, without specifying whether characteristics and outcomes differed from CA-AKI [6]. A recent North-American retrospective cohort study showed that patients developing HA-AKI had more comorbidities, higher mortality rate and were more prone to need intensive care unit (ICU) care than patients with CA-AKI [7]. Another retrospective study from the United Kingdom compared the epidemiology and outcomes of patients with CA-AKI to those with HA-AKI and also found that the latter had a grimmer prognosis in spite of similar risk factors [8].

An additional issue is that early recognition and management in the Emergency Department (ED) of patients with CA-AKI may have a positive impact on prognosis. In an intensive care setting, a delayed nephrology consultation was associated with higher mortality [9, 10]. In HA-AKI patients, early involvement of a nephrology team resulted in a lower rate of creatinine increase [11]. However, in septic patients, early goal-directed therapy failed to reduce the incidence of AKI [12]. Since the implementation of Kidney Disease Improving Global outcomes (KDIGO) guidelines to diagnose and grade AKI, no study has evaluated the impact of its early recognition and management on subsequent outcomes. There is indeed a lack of data to assess the impact of early AKI management on mortality, length of hospital stay, need of renal replacement therapy (RRT), or subsequent kidney function.

We therefore aimed to better define the characteristics and prognosis of CA-AKI in patients with and without CKI, the impact of CA-AKI recognition and management within the first 24 h, and the long-term outcomes of these patients compared to patients with stable CKI.

During the 8 weeks of the screening period, 8464 patients were admitted in the ED of whom 653 had an eGFR <60 ml/mn/1.73 m². We excluded 64 patients: 7 were already on chronic dialysis, 54 with a ≤ 26.5 μmol/L transient rise in serum creatinine and return within 24 h to an eGFR >60 ml/mn/1.73 m² and 3 patients had two admissions during the screening period. Finally, the panel of nephrologists identified 248 patients with stable CKI, 104 with CA-ACKI and 237 with CA-AKI. Table 1 shows the main characteristics of these 589 patients comparing CKI, CA-AK and CA-ACKI patients. Of note, they were predominantly elderly, with a high prevalence of hypertensive disease. ACEIs, ARBs and diuretics doses were similar in the 3 groups (Table 1). Among the 341 patients with CA-AKI and according to the chart review by the panel of nephrologists, prerenal causes were principally due to hypovolemia and heart failure.

Risk factors for CA-ACKI in the 352 CKI patients were male gender (OR: 1.71, 95% CI: 1.04-2.81, p = 0.03) and diuretics use. ARBs use was significantly associated with CA-AKI in univariate analysis, but not in multivariate analysis (Table 2).

Overall, 44.6% (152/341) of the patients with CA-AKI were adequately managed in the ED. Age, gender, previous comorbidities such as diabetes, hypertension and heart failure were not associated with the rate of adequate management (Table 3). In multivariate analysis, presence of underlying CKI was just associated with lower management adequacy. AKI severity was associated with an increase in management adequacy. Adequate AKI management had no impact on ICU stay, need for RRT, or 1-year mortality, and was not associated with more renal recovery in the 313 patients who had a minimum 28-day follow-up (Table 4). Adequate AKI management was associated with a significantly longer hospital stay and more hospitalization days within the subsequent year. This trend subsisted after adjustment for age, gender, presence of diabetes, CKI and heart failure (Table 5). Results were also similar when each quality criteria were analyzed separately (data not shown).

Three-year mortality in CKI and CA-ACKI patients was 21 and 48%, and in patients with only CA-AKI 40% (p < 0.001) (Fig. 1). Mortality was significantly associated with increasing age (OR: 1.04, 95% CI: 1.01-1.06, p = 0.001), hypertension (OR: 1.80, 95% CI: 1.01-3.20, p = 0.045), neoplasia (OR: 2.41, 95% CI: 1.07–5.45, p = 0.034) and ischemic heart disease (OR: 2.70, 95% CI: 1.57–4.64, p = 0.001). Compared to patients with stable CKI on admission, CA-AKI, either alone or superimposed on CKI remained significantly associated with three-year mortality in multivariate analysis (Table 6). Renal function could be ascertained in the 299 patients (47%) who had at least one-year follow-up (mean follow-up of 117 ± 33 weeks). Renal function decline was observed in one third of the patients and was significantly associated with age (OR: 1.04, 95% CI: 1.01–1.07, p = 0.001) and male gender (OR: 2.18, 95% CI: 1.22–3.90, p = 0.008). Compared to CKI patients, those with only CA-AKI had less decrease of renal function (Table 6).

Patients with a CA-AKI represented 4% of all admissions to the ED during the 8-weeks period of our study. Most of these patients were elderly, with major comorbidities and potentially nephrotoxic medications. CA-AKI in our population was predominantly prerenal and K-DIGO stage 1 at presentation.

Characteristics of our patients were similar to those of the patients described in two previous studies performed in industrialized countries such as the Unites States or the UK [7, 8]. The main differences with the latter study were higher CA-AKI prevalence and severity and the mortality rate at 14 months (45%). A delayed access to the ED leading to a belated diagnosis of AKI and a different patient’s socio-economic profile might explain such differences with a more densely urbanized city such as Geneva.

A high percentage of our patients had potentially nephrotoxic drugs (46% ARBs and/or ACEIs, 37% diuretics, NSAIDs 6%). In CKI patients, NSAIDs were uncommonly used, which reflect likely awareness by their physicians of the deleterious effects of these compounds on renal function. Antibiotics were present also in a minority of our patients and this low number precluded us to infer their responsibility in CA-AKI. Regarding diuretics, there are surprisingly few studies which focus on their role in inducing AKI, especially when they are combined with renin-angiotensin system (RAS) blockers [15]. Fifty-two percent of our patients with AKI had diuretics and they were associated (mainly in fixed dose combinations) with RAS blockers in one quarter of the patients with CA-AKI. Indeed, nearly one half of our patients were either treated by ACEIs or ARBs. This reflects the trend to prescribe these medications in patients with CKI and follows current guidelines which endorse RAS blockers as the cornerstone for nephroprotection. In this study, regarding the occurrence of CA-AKI, only diuretics were found to be detrimental in our population in multivariate analysis. No difference was found between use of ACEis and ARBs in terms of impact on outcome, contrary to the results of recent publications which incriminate both ACEIs and ARBS with renal impairment [16, 17].

For many decades, male gender was recognized as a risk factor for development of CKI and AKI as well. There are multiple explanations, ranging from a potentially more harmful lifestyle, a genetic predisposition to CKI, to an increased rate of post-renal impairment due to prostate hypertrophy [5, 6].

To the best of our knowledge, no studies have examined the impact of early recognition of CA-AKI, its diagnosis work-up and early treatment intervention on hospital outcomes. Only 53% of our patients presenting with CA-AKI were identified as having impaired kidney function. An adequate work-up was performed in 57% of them and ED early intervention in 73%. The discrepancy between recognition and intervention rates can be explained by the high percentage of a prerenal etiology in our study. Although prerenal AKI was probably recognized and fluid replacement prescribed by ED physicians, its severity might not always have been considered as a serious problem worth mentioning in the medical file. Pre-defined quality criteria for management were reached in fewer patients with underlying CKI. This may reflect a tendency in our ED residents to overlook a mild CA-ACKI. Adequate CA-AKI management had no effect on outcomes such as mortality and was unexpectedly associated with a higher length of hospital stay and more hospitalization days within the subsequent year. This unexpected result may reflect either a more severe kidney injury in the adequate AKI management group or delayed discharge of these patients by physicians waiting for recovery of renal function, although renal recovery was not higher in the adequate AKI management group. AKI management may occur too late in patients with CA-AKI to be really effective or a delayed intervention within the ED may not impact outcomes in patients hospitalized after being admitted to the ED.

Regarding long-term outcomes, 3-year mortality was significantly associated in patients with increasing age, coronary heart disease, neoplasia and CA-AKI. Renal function decline was found to be less pronounced in patients with primary CA-AKI, compared to those with previous CKI and CA-ACKI. Outcomes of 130 patients with CA-AKI and prospectively followed for 5 years were recently published that showed that CA-AKI doubled the risk of death and was associated with a 5.7 fold increase in the risk of reaching stage 3 CKI, as compared to 312 patients with normal renal function [18]. Transient azotemia in this study also increased by 2.4 fold the risk of reaching stage 3 CKI. Our results were similar to these data in terms of mortality but differed regarding development of CKI. The older age of our patients and subsequently their increased mortality, their shorter follow-up, the lack of comparison with patients with normal renal function on admission, may explain this apparent discrepancy. Moreover, our CKI patients admitted in the ED were slightly older than those with CA-AKI only. CKD and increasing age are intrinsically linked and the GFR decline is explained by the physiological senescence of kidneys [19]. Severity of CA-AKI was also more pronounced in our CKI patients of whom 57% had stage II/III AKI versus 21% in patients with CA-AKI without previous CKI.

A retrospective analysis from a cohort of US male veterans compared 158 HA- and 560 CA-AKI and found that the latter was 3.5 times more frequent but had similar outcomes to HA-AKI with identical requirements of RRT and an in-hospital mortality of 19.6% [20]. Regarding the specific long-term mortality risk increase in CKI patients after an episode of AKI, this has mainly been studied in patients with HA-AKI [21]. There are few studies which assess the long-term outcome of CKI patients with CA-AKI. In a retrospective UK study, short- and long-term outcomes of 230 patients with CA-AKI (of whom 38% had preexisting CKI disease) compared to patients matched for age and gender without CA-AKI gave a 3-month and 3-year mortality of 16.5% and 45%, respectively [22]. Three-year mortality was not related to the progression of CKI and was increased in those with CA-ACKI. Renal function decline at 3 years was more frequent in this study in patients with CA-ACKI (83%) than in patients with primary CA-AKI (49%). Differences in study design likely explain these discrepancies with our results.

Our prospective data reflect what has previously been described, predominantly in retrospective studies. These studies mostly concern the western world and differ notably from data obtained in less industrialized countries. In these latter reports, demographics of patients with CA-AKI, its severity and short-term mortality do not match our data, although the lack of studies coming from these countries preclude any firm conclusion. For example, mortality rate was 11% in a Indian population with community-acquired AKI, but patients had a mean age of 40 years and etiologies were mainly due to preventable diseases; this epidemiology may have changed over the last 25 years [23]. An observational Brazilian study comparing the differences in patients with community-, hospital- and ICU-acquired AKI underlined the important differences in outcomes based on its etiology [24]. In this study, only 2.2% of the patients had CA-AKI of pre-renal origin, with a 23% in-hospital mortality. Overall need of RRT was 68% in the whole population, which reflects a different case-mix of patients with CA-AKI when compared to our population. Our results reflect typical patients in western societies admitted in the ED with CA-AKI and do not apply to other populations.

Limitations of our study include its observational design, its small size and monocentric nature. Furthermore, we relied on medical files data recorded by ED physicians for the management of AKI which could have biased the quality criteria classification and analysis of outcomes. We only studied patients with a GFR < 60 ml/mn/1.73 m² and therefore may have missed some CA-AKI within the range 90 to 60 ml/mn/1.73 m². By recording the dosage of RAS inhibitors and diuretics, we tried to exclude a different impact on the occurrence of CA-AKI due to a higher dosage of one class of RAS inhibitors. Our follow-up, though complete, is short and most of the episodes of CA-AKI were mild. Although we were able to analyze the short-term recovery of renal function in 93% of our patients, we had data in only 47% of our patients who had a minimum follow-up of 1 year. Indeed, it has been shown that most patients presenting an episode of AKI only stabilize their renal function 1 year after the episode [25].

Strengths of our study are its prospective design, the analysis of the impact of early AKI management on the outcomes, the precise quantification of RABs and diuretics use in CKI and CA-ACKI patients and the 3 year follow-up.

Our results show that CA-AKI in developed countries is not identified properly in nearly half of cases within the ED of an academic hospital, is frequently found in the elderly and its main etiology is prerenal origin. Medications such as RAS blockers and diuretics are frequently encountered, especially in patients with CKI disease. Although, early adequate AKI management does not seem to significantly change short-term outcomes such as mortality, renal recovery and length of stay, this has to be further studied in larger prospective studies.