Introduction
Background
Objectives
Methods
Study design
Setting and participants
Variables
Data measurement
Bias
Study size
Quantitative variables
Statistical methods
Results
Participants
Descriptive data
Outcome data
Variable | N | Total | Survivors | Non-survivors | P |
---|---|---|---|---|---|
n | 157 | 129 | 28 | ||
Birth weight (g) (IQR) | 157 | 1405 (960) | 1480 (750) | 855 (955) | 0.0017 |
Gestational age (weeks/days) (IQR) | 157 | 31.2 (6.2) | 32.0 (5.1) | 27.0 (5.3) | < 0.001 |
Assisted delivery n (%) | 156 | 133/156, 85% | 107/128, 84% | 26/28, 93% | 0.093 |
Apgar 5 min (IQR) | 153 | 8 (2) | 8 (2) | 6 (3) | < 0.001 |
Age at diagnosis (IQR) | 157 | 9 (12) | 8 (11) | 11 (13.2) | 0.039 |
Re-NEC n (%) | 156 | 8/156, 5% | 7/128, 5% | 1/28, 4% | 0.0025 |
Variable | N | Total | Survivors | Non-Survivors | P |
---|---|---|---|---|---|
Minimum Hgb (g/l) before NEC onset (IQR) | 77 | 132 (52) | 142 (50) | 114 (40.2) | 0.035 |
Minimum Hgb (g/l) < 7 days before NEC onset (IQR) | 132 | 144 (53.5) | 153 (53) | 127 (29) | 0.0029 |
Hgb at disease presentation (g/l) (IQR) | 149 | 140 (50) | 146 (49.2) | 121 (29) | < 0.001 |
Minimum Hgb during NEC (g/l) (IQR) | 150 | 114 (35) | 119 (37) | 103 (19) | 0.025 |
Minimum WBC (G/L) before NEC onset (IQR) | 75 | 7.4 (5.85) | 7.71 (5.6) | 5.3 (3.78) | 0.016 |
Maximum WBC (G/L) < 7 days before NEC onset (IQR) | 120 | 13.8 (8.93) | 13.2 (8.13) | 15.6 (10.4) | 0.049 |
Minimum PLT (G/l) before NEC onset (IQR) | 74 | 164 (111) | 169 (116) | 97 (78) | 0.015 |
Minimum PLT at disease presentation (G/l) (IQR) | 148 | 214 (211) | 222 (194) | 116 (228) | 0.011 |
Minimum PLT (G/l) during NEC (IQR) | 150 | 157 (172) | 174 (168) | 57 (133) | 0.0024 |
Minimum pH < 7 days before NEC onset (IQR) | 70 | 7.26 (0.166) | 7.26 (0.15) | 7.14 (0.157) | 0.016 |
Maximum CRP before NEC onset (IQR) | 60 | 0 (8) | 0 (7) | 4 (32) | 0.1 |
Maximum CRP (mg/l) < 7 days before NEC onset (IQR) | 49 | 0 (6) | 0 (5.25) | 0 (24.5) | 0.4 |
CRP at disease presentation (mg/L) (IQR) | 135 | 7 (19.5) | 7 (18) | 11 (33.5) | 0.1 |
Maximum CRP (mg/l) during NEC (IQR) | 141 | 38 (97) | 35 (103) | 40.5 (66.5) | 0.83 |
Maximum percentage of premature neutrophils at disease onset (%) (IQR) | 109 | 23 (30) | 21 (30.5) | 35.5 (30.2) | 0.054 |
Lactate at disease presentation (mmol/L) (IQR) | 139 | 2.2 (2.1) | 2.1 (1.8) | 3.95 (4.38) | 0.0078 |
Maximum Lactate (mmol/l) during NEC (IQR) | 141 | 2.7 (2.5) | 2.4 (2.1) | 5.25 (5.85) | < 0.001 |
Base excess at disease presentation (mmol/L) (IQR) | 136 | − 2.4 (5.97) | − 2 (5.48) | − 7.9 (6.58) | < 0.001 |
Maximum base excess during NEC (mmol/L) (IQR) | 140 | − 3.9 (6.23) | − 3.1 (5.35) | − 10.8 (9.3) | < 0.001 |
Maximum INR during NEC (IQR) | 38 | 1.34 (0.617) | 1.2 (0.6) | 1.7 (0.33) | 0.024 |
ROC analysis | Univariate regression | ||||||||
---|---|---|---|---|---|---|---|---|---|
Value | AUC | cutoff | Sensitivity | Specificity | PPV | NPV | OR | CI95% | P |
Bell stage III | NA | NA | NA | NA | NA | NA | 7.1 | 3–18 | < 0.001 |
Gestational age (weeks/days) | 0.7 | 29.0 | 0.71 | 0.7 | 0.34 | 0.92 | 5.8 | 2.4–15 | < 0.001 |
Apgar 1 min | 0.73 | 5.5 | 0.75 | 0.57 | 0.28 | 0.91 | 4 | 1.7–11 | 0.0033 |
Apgar 5 min | 0.7 | 6.5 | 0.57 | 0.8 | 0.39 | 0.89 | 4.8 | 2.1–12 | < 0.001 |
Apgar 10 min | 0.7 | 7.5 | 0.61 | 0.78 | 0.39 | 0.9 | 3.2 | 1.3–8.2 | 0.011 |
PDA | NA | NA | NA | NA | NA | NA | 5.5 | 2.3–14 | < 0.001 |
Conservative treatment only | NA | NA | NA | NA | NA | NA | 0.4 | 0.17–0.93 | 0.032 |
NEC surgery | NA | NA | NA | NA | NA | NA | 2.5 | 1.1–5.8 | 0.032 |
Minimum Hb (g/l) < 7 days before NEC onset | 0.7 | 141 | 0.78 | 0.6 | 0.29 | 0.93 | 3.9 | 1.6–10 | 0.0042 |
Minimum Hb during NEC (g/l) | 0.64 | 113 | 0.76 | 0.56 | 0.26 | 0.92 | 3.1 | 1.2–8.1 | 0.018 |
Minimum pH < 7 days before NEC onset | 0.75 | 7.2 | 0.67 | 0.84 | 0.38 | 0.94 | 10 | 2.3–56 | 0.0032 |
Hgb at disease presentation (g/l) | 0.72 | 141 | 0.88 | 0.56 | 0.29 | 0.96 | 3.6 | 1.5–9.4 | 0.0061 |
Lactate at disease presentation (mmol/L) | 0.68 | 3.8 | 0.55 | 0.83 | 0.38 | 0.91 | 3.8 | 1.4–10 | 0.0079 |
Maximum Lactate (mmol/l) during NEC | 0.78 | 3.8 | 0.77 | 0.75 | 0.36 | 0.95 | 3.4 | 1.3–8.8 | 0.011 |