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Endocrine

Erschienen in:

01.10.2011 | Mini Review

Role of biological targeted therapies in gastroenteropancreatic neuroendocrine tumours

verfasst von: Kein-Leong Yim

Erschienen in: Endocrine | Ausgabe 2/2011

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Abstract

Approximately two-thirds of neuroendocrine tumours (NET) occur in the gastrointestinal tract and over 60% present with metastases. With greater insight into molecular pathways involved in tumour progression, opportunities are presented for the use of targeted therapies in NET. Although a wide array of targeted agents has been investigated, only a handful has emerged as forerunners from recent clinical trials. This literature review focuses on the use of anti-angiogenic monoclonal antibody bevacizumab, as well as small molecule inhibitors sunitinib and everolimus.

S. La Rosa, S. Uccella, G. Finzi, L. Albarello, F. Sessa, C. Capella, Localization of vascular endothelial growth factor and its receptors in digestive endocrine tumors: correlation with microvessel density and clinicopathologic features. Hum. Pathol. 34, 2–18 (2003)CrossRef

B. Terris, J.Y. Scoazec, L. Rubbia, L. Bregeaud, M.S. Pepper, P. Ruszniewski, J. Belghiti, J. Flejou, C. Degott, Expression of vascular endothelial growth factor in digestive neuroendocrine tumours. Histopathology 32, 133–138 (1998)PubMedCrossRef

J. Zhang, Z. Jia, Q. Li, L. Wang, A. Rashid, Z. Zhu, D.B. Evans, J.N. Vauthey, K. Xie, J.C. Yao, Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors. Cancer 109, 1478–1486 (2007)PubMedCrossRef

S.R. Silva, K.A. Bowen, P.G. Rychahou, L.N. Jackson, H.L. Weiss, E.Y. Lee, C.M. Townsend Jr, B.M. Evers, VEGFR-2 expression in carcinoid cancer cells and its role in tumor growth and metastasis. Int. J. Cancer 128, 1045–1056 (2011)

T. Shah, D. Hochhauser, R. Frow, A. Quaglia, A.P. Dhillon, Caplin, M.E.: Epidermal growth factor receptor expression and activation in neuroendocrine tumours. J. Neuroendocrinol. 18, 355–360 (2006)PubMedCrossRef

J.C. Yao, A. Phan, P.M. Hoff, H.X. Chen, C. Charnsangavej, S.C. Yeung, K. Hess, C. Ng, J.L. Abbruzzese, J.A. Ajani, Targeting vascular endothelial growth factor in advanced carcinoid tumor: a random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alpha-2b. J. Clin. Oncol. 26, 1316–1323 (2008)PubMedCrossRef

M.H. Kulke, H.J. Lenz, N.J. Meropol, J. Posey, D.P. Ryan, J. Picus, E. Bergsland, K. Stuart, L. Tye, X. Huang, Activity of sunitinib in patients with advanced neuroendocrine tumors. J. Clin. Oncol. 26, 3403–3410 (2008)PubMedCrossRef

E. Raymond, L. Dahan, J.L. Raoul, Y.J. Bang, I. Borbath, C. Lombard-Bohas, J. Valle, P. Metrakos, D. Smith, A. Vinik, Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. NEJM 364, 501–513 (2011)PubMedCrossRef

T.J. Hobday, J. Rubin, K. Holen, J. Picus, R. Donehower, R. Marschke, W. Maples, R. Lloyd, M. Mahoney, C. Erlichman, MC044h, a phase II trial of sorafenib in patients (pts) with metastatic neuroendocrine tumors (NET): A phase II Consortium (P2C) study. J. Clin. Oncol. 25, abstract 4504 (2007)

10.

I. Duran, J. Kortmansky, D. Singh, H. Hirte, W. Kocha, G. Goss, L. Le, A. Oza, T. Nicklee, J. Ho, A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas. Br. J. Cancer 95, 1148–1154 (2006)PubMedCrossRef

11.

J.C. Yao, A.T. Phan, D.Z. Chang, R.A. Wolff, K. Hess, S. Gupta, C. Jacobs, J.E. Mares, A.N. Landgraf, A. Rashid, Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low- to intermediate-grade neuroendocrine tumors: Results of a phase II study. J. Clin. Oncol. 26, 4311–4318 (2008)PubMedCrossRef

12.

J.C. Yao, C. Lombard-Bohas, E. Baudin, L.K. Kvols, P. Rougier, P. Ruszniewski, S. Hoosen, J. St.Peter, T. Haas, D. Lebwohl, Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: A phase II trial. J. Clin. Oncol. 28, 69–76 (2010)PubMedCrossRef

13.

J.C. Yao, M.H. Shah, T. Ito, C.L. Bohas, E.M. Wolin, E. Van Cutsem, T.J. Hobday, T. Okusaka, J. Capdevila, E.G. de Vries, Everolimus for advanced pancreatic neuroendocrine tumors. NEJM 354, 514–523 (2011)CrossRef

14.

M.H. Shah, T. Ito, C. Lombard-Bohas, E.M. Wolin, E. Van Cutsem, C. Sachs, R.E. Winkler, J. Lincy, T.J. Hobday, J.C. Yao, Everolimus in patients with advanced pancreatic neuroendocrine tumors (pNET): Updated results of a randomized, double-blind, placebo-controlled, multicenter phase III trial (RADIANT-3). J. Clin. Oncol. 29, 158 (2011)CrossRef

15.

J.C. Yao, J.D. Hainsworth, E. Baudin, M. Peeters, D. Hoersch, L.B. Anthony, J. Klimovsky, K. Grouss, V. Jehl, M. Pavel, Everolimus plus octreotide LAR (E + O) versus placebo plus octreotide LAR (P + O) in patients with advanced neuroendocrine tumors (NET): Updated results of a randomized, double-blind, placebo-controlled, multicenter phase III trial (RADIANT-2). J Clin Oncol 29, 159 (2011)CrossRef

16.

J.C. Yao, A.T. Phan, D. Fogleman, C.S. Ng, C.B. Jacobs, C.D. Dagohoy, C. Leary, K.R. Hess, Randomized run-in study of bevacizumab (B) and everolimus (E) in low- to intermediate-grade neuroendocrine tumors (LGNETs) using perfusion CT as functional biomarker. J. Clin. Oncol. 28, abstract 4002 (2010)

17.

G. Vitale, W.W. de Herder, P.M. van Koetsveld, M. Waaijers, W. Schoordjk, E. Croze, A. Colao, S.W.J. Lamberts, L.J. Hofland, IFN-β is a highly potent inhibitor of gastroenteropancreatic neuroendocrine tumor cell growth in vitro. Cancer Res. 66(1), 554–562 (2006)PubMedCrossRef

18.

G. Vitale, P.M. van Koetsveld, W.W. de Herder, K. van der Wansem, J.A. Janssen, A. Colao, G. Lombardi, S.W. Lamberts, L.J. Hofland, Effects of type I interferons on IGF-mediated autocrine/paracrine growth of human neuroendocrine tumor cells. Am. J. Physiol. Endocrinol. Metab. 296(3), E559–E566 (2009)PubMedCrossRef

19.

A.W. Tolcher, M.L. Rothenberg, J. Rodon, D. Delbeke, A. Patnaik, L. Nguyen, F. Young, Y. Hwang, C. Haqq, I. Puzanov, Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J. Clin. Oncol. 27, 5800–5807 (2009)PubMedCrossRef

20.

D.L. Reidy, E. Hollywood, M. Segal, L. Saltz, A phase II clinical trial of MK-0646, an insulin-like growth factor-1 receptor inhibitor (IGF-1R), in patients with metastatic well-differentiated neuroendocrine tumors (NETs). ASCO Meeting Abstracts, vol. 28 (2010), p. 4163

21.

L. Kvols, B. Wiedenmann, K. Oberg, J. Glusman, T. O’Dorisio, W. de Herder, B. Gao, R. Arnold, L. Anthony, SOM230 Carcinoid Study Group, Safety and efficacy of pasireotide (SOM230) in patients with metastatic carcinoid tumors refractory or resistant to octreotide LAR: Results of a phase II study. ASCO Gastrointestinal Cancers Symposium, Abstract 171, 2006

22.

K.E. Oberg, J.C. Reubi, D.J. Kwekkeboom, E.P. Krenning, Role of somatostatins in gastroenteropancreatic neuroendocrine tumor development and therapy. Gastroenterology 139(3), 742–753, 753.e1 (2010)

23.

M. Caraglia, M. Marra, P. Tagliaferri, S.W. Lamberts, S. Zappavigna, G. Misso, F. Cavagnini, G. Facchini, A. Abbruzzese, L.J. Hofland, G. Vitale, Emerging strategies to strengthen the anti-tumour activity of type I interferons: overcoming survival pathways. Curr. Cancer Drug Targets 9(5), 690–704 (2009)PubMedCrossRef

24.

E. Allen, I.B. Walters, D. Hanahan, Brivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition. Clin. Cancer Res. 17(16), 5299–5310 (2011)

25.

E.A. Eisenhauer, P. Therasse, J. Bogaerts, L.H. Schwartz, D. Sargent, R. Ford, J. Dancey, S. Arbuck, S. Gwyther, M. Mooney, L. Rubinstein, L. Shankar, L. Dodd, R. Kaplan, D. Lacombe, J. Verweij, New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur. J. Cancer 45, 228–247 (2009)PubMedCrossRef

26.

P. Therasse, S.G. Arbuck, E.A. Eisenhauer, New guidelines to evaluate the response to treatment in solid tumors (RECIST Guidelines). J. Natl. Cancer Inst. 92, 205–216 (2000)PubMedCrossRef

Titel: Role of biological targeted therapies in gastroenteropancreatic neuroendocrine tumours
verfasst von: Kein-Leong Yim
Publikationsdatum: 01.10.2011
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 2/2011
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-011-9513-y

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