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07.09.2017 | Review

Role of calcitonin gene-related peptide in energy metabolism

verfasst von: William Gustavo Lima, Gleuber Henrique Marques-Oliveira, Thaís Marques da Silva, Valéria Ernestânia Chaves

Erschienen in: Endocrine | Ausgabe 1/2017

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Abstract

Purpose

Calcitonin gene-related peptide (CGRP) is a neuropeptide produced by alternative tissue-specific splicing of the primary transcript of the CALC genes. CGRP is widely distributed in the central and peripheral nervous system, as well as in several organs and tissues. The presence of CGRP in the liver and brown and white adipose tissue suggests an effect of this neuropeptide on regulation of energy homeostasis.

Methods

In this review, we summarize the current knowledge of the effect of CGRP on the control of energy metabolism, primarily focusing on food intake, thermoregulation and lipid metabolism in adipose tissue, liver and muscle.

Results

CGRP induces anorexia, stimulating anorexigenic neuropeptide and/or inhibiting orexigenic neuropeptide expression, through cAMP/PKA pathway activation. CGRP also induces energy expenditure, increasing the skin temperature and brown adipose tissue thermogenesis. It has been also suggested that information related to peripheral lipid stores may be conveyed to the brain via CGRP-sensory innervation from adipose tissue. More recently, it was demonstrated that mice lacking αCGRP are protected from obesity induced by high-fat diet and that CGRP regulates the content of lipid in liver, muscle and adipose tissue.

Conclusions

It is unclear the receptor responsible by CGRP effects, as well as whether this neuropeptide acts directly or indirectly in liver, muscle and adipose tissue.

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Titel: Role of calcitonin gene-related peptide in energy metabolism
verfasst von: William Gustavo Lima
Gleuber Henrique Marques-Oliveira
Thaís Marques da Silva
Valéria Ernestânia Chaves
Publikationsdatum: 07.09.2017
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 1/2017
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-017-1404-4

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