Introduction
Clinical results with CAR-T cells in relapsed and refractory B-ALL
Author | No. patients | Gene transfer | Co-stim. domain | Lymphodepl. chemo | CAR‑T cell doses | Outcome |
---|---|---|---|---|---|---|
Brentjens (2011) [27] | 1 | Gamma RV | CD28 | CY | 1.4 × 108 | N/A |
Brentjens (2013) [27] | 5 A | Gamma RV | CD28 | CY | 1.4–3.2 × 108 | 5 CR |
Cruz (2013) [27] | 8 | RV | CD28 | – | 1.9 × 107–1.13 × 108 | 1 CR 2 CCR 1 PR 3 PD 1 SD |
Grupp (2013) [28] | 2 C | LV | CD28 | – | 1.4 × 106–1.2 × 107/kg | 2 CR |
Davila (2014) [27] | 16 A | Gamma RV | CD28 | CY | 3 × 106/kg | 15 CR |
Maude (2014) [8] | 30 (25C/5A) | LV | 4‑1BB | CY/Flu or CY/VP or other | 0.76–17.36 × 106/kg | 27 CR 3 NR (19 CCR) |
Dai (2015) [27] | 9 | LV | 4‑1BB | C‑MOAD | 3 × 106–1 × 107/kg | 6 CR 3 PR |
Lee (2015) [17] | 21 C+A | Gamma RV | CD28 | CY/Flu | 1 × 106 vs 3 × 106/kg | 14 CR 4 PD 3 SD |
Park (2015) [29] | 33 A | N/A | N/A | N/A | N/A | 91% CR |
Gardner (2016) [27] | 9 | N/A | N/A | Chemo | 2 × 106–1 × 107/kg | 7 CR 2 Relapse |
Turtle (2016) [10] | 30 A | LV | CD28 | CY/Flu | 2 × 105–2 × 107/kg | 29 CR (27 MRD−) |
Zhu (2016) [27] | 2 | LV | 4‑1BB | CY/Flu | 1 × 106/kg | 2 CR |
Callahan (2017) [30] | 59 | LV + RV | N/A | Chemo | N/A | 55 CR 20 Relapse |
Chen (2017) [27] | 6 | LV | CD28 | CY/Flu | 3.8 × 107–4.1 × 108/kg | 5 CR (MRD−) 1 NR 4 Relapse |
Gardner (2017) [11] | 45 C+A | LV | 4‑1BB | CY, CY/Flu | 5 × 105–1 × 107/kg | 40 CR (MRD−) 3 NC 18 Relapse |
Pan (2017) [27] | 51 | LV | 4‑1BB | CY/Flu | 5 × 103–1.4 × 107/kg | 45 CR (9 MRD−) 3 NR 3 died 2 Relapse |
Wang (2017) [27] | 6 | N/A | N/A | CY/BU/Flu | 1.2–8.5 × 106/kg | 3 CR 1 died 2 NR 2 Relapse |
Fry (2018) [27] | 21 | LV | 4‑1BB | CY/Flu | 3 × 105–3 × 106/kg | 12 CR (9 MRD−) 8 relapse |
Maude (2018) [6] | 75 C+A | LV | 4‑1BB | CY/Flu | 0.2–5.4 × 106/kg | 45 CR+16 CRi (61 MRD−) 22 Relapse |
Park (2018) [9] | 53 A | Gamma RV | CD28 | CY/Flu | N/A | 44 CR (32 MRD−) 25 Relapse |
Park (2018) [27] | 2 | LV | 4‑1BB | CY/Flu | 4.6 × 106/kg | 1 CR |
Wei (2018) [31] | 22 | LV | 4‑1BB | CY/Flu | 3–10 × 107/kg | 20 CR 2 SD 1 died 8 Relapse |
Weng (2018) [32] | 5 | LV | CD28 | CY/Flu | 5 × 104–1 × 106/kg | 3 CR 2 Relapse |