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14.02.2019 | Original Research

Role of DIDO1 in Progression of Esophageal Squamous Cell Carcinoma

verfasst von: Mohammad Mahdi Forghanifard, Pegah Naeimi Khorasanizadeh, Mohammad Reza Abbaszadegan, Afsaneh Javdani Mallak, Meysam Moghbeli

Erschienen in: Journal of Gastrointestinal Cancer | Ausgabe 1/2020

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Abstract

Purpose

Apoptosis is one of the main involved processes during development and organogenesis and its aberration may result in tumorigenesis. In the present study, due to the role of death inducer-obliterator 1 (DIDO1) in activation of caspases 9 and 3 during the apoptosis process, the role of DIDO1 as the shortest splicing variant of the DIDO gene was assessed for the first time in esophageal squamous cell carcinoma (ESCC) patients.

Methods

DIDO1 mRNA expression in tumor tissues from 50 ESCC patients was compared to their corresponding margin normal tissues using the real-time polymerase chain reaction (RT-PCR).

Results

Nine out of 50 (18%) and 13 out of 50 (26%) cases had DIDO1 under- and overexpression, respectively. There was a significant correlation between DIDO1 mRNA expression and tumor depth of invasion (p = 0.050). Also, there was a significant correlation between age of patients and levels of DIDO1 mRNA expression (p = 0.039).

Conclusions

This study is the first report that assessed the DIDO1 expression in ESCC patients and revealed its probable role in the early steps of tumor progression and metastasis. Therefore, DIDO1 can be suggested as a marker for the primary ESCCs.

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–32. https://doi.org/10.3322/caac.21338.CrossRefPubMed

Wei WQ, Chen ZF, He YT, Feng H, Hou J, Lin DM, et al. Long-term follow-up of a community assignment, one-time endoscopic screening study of esophageal cancer in China. J Clin Oncol. 2015;33(17):1951–7. https://doi.org/10.1200/JCO.2014.58.0423.CrossRefPubMedPubMedCentral

Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006;24(14):2137–50. https://doi.org/10.1200/JCO.2005.05.2308.CrossRefPubMed

Jacobson MD, Weil M, Raff MC. Programmed cell death in animal development. Cell. 1997;88(3):347–54.CrossRefPubMed

Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972;26(4):239–57.CrossRefPubMedPubMedCentral

Raff M. Cell suicide for beginners. Nature. 1998;396(6707):119–22. https://doi.org/10.1038/24055.CrossRefPubMed

Ellis RE, Yuan JY, Horvitz HR. Mechanisms and functions of cell death. Annu Rev Cell Biol. 1991;7:663–98. https://doi.org/10.1146/annurev.cb.07.110191.003311.CrossRefPubMed

Thornberry NA, Lazebnik Y. Caspases: enemies within. Science. 1998;281(5381):1312–6.CrossRefPubMed

Budihardjo I, Oliver H, Lutter M, Luo X, Wang X. Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol. 1999;15:269–90. https://doi.org/10.1146/annurev.cellbio.15.1.269.CrossRefPubMed

10.

Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem. 1999;68:383–424. https://doi.org/10.1146/annurev.biochem.68.1.383.CrossRefPubMed

11.

Salvesen GS, Dixit VM. Caspases: intracellular signaling by proteolysis. Cell. 1997;91(4):443–6.CrossRefPubMed

12.

Wagner AJ, Kokontis JM, Hay N. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. Genes Dev. 1994;8(23):2817–30.CrossRefPubMed

13.

Kumar A, Commane M, Flickinger TW, Horvath CM, Stark GR. Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science. 1997;278(5343):1630–2.CrossRefPubMed

14.

Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell. 1992;69(1):119–28.CrossRefPubMed

15.

Ham J, Babij C, Whitfield J, Pfarr CM, Lallemand D, Yaniv M, et al. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron. 1995;14(5):927–39.CrossRefPubMed

16.

Baichwal VR, Baeuerle PA. Activate NF-kappa B or die? Curr Biol. 1997;7(2):R94–6.CrossRefPubMed

17.

Futterer A, Campanero MR, Leonardo E, Criado LM, Flores JM, Hernandez JM, et al. Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms. J Clin Invest. 2005;115(9):2351–62. https://doi.org/10.1172/JCI24177.CrossRefPubMedPubMedCentral

18.

Futterer A, Raya A, Llorente M, Izpisua-Belmonte JC, de la Pompa JL, Klatt P, et al. Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development. Cell Death Differ. 2012;19(1):132–43. https://doi.org/10.1038/cdd.2011.62.CrossRefPubMed

19.

Garcia-Domingo D, Ramirez D, Gonzalez de Buitrago G, Martinez AC. Death inducer-obliterator 1 triggers apoptosis after nuclear translocation and caspase upregulation. Mol Cell Biol. 2003;23(9):3216–25.CrossRefPubMedPubMedCentral

20.

Gatchalian J, Futterer A, Rothbart SB, Tong Q, Rincon-Arano H, Sanchez de Diego A, et al. Dido3 PHD modulates cell differentiation and division. Cell Rep. 2013;4(1):148–58. https://doi.org/10.1016/j.celrep.2013.06.014.CrossRefPubMedPubMedCentral

21.

Garcia-Domingo D, Leonardo E, Grandien A, Martinez P, Albar JP, Izpisua-Belmonte JC, et al. DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development. Proc Natl Acad Sci U S A. 1999;96(14):7992–7.CrossRefPubMedPubMedCentral

22.

Moghbeli M, Forghanifard MM, Aarabi A, Mansourian A, Abbaszadegan MR. Clinicopathological sex-related relevance of musashi1 mRNA expression in esophageal squamous cell carcinoma patients. Pathol Oncol Res. 2014;20(2):427–33. https://doi.org/10.1007/s12253-013-9712-3.CrossRefPubMed

23.

Raeisossadati R, Farshchian M, Ganji A, Tavassoli A, Velayati A, Dadkhah E, et al. Quantitative analysis of TEM-8 and CEA tumor markers indicating free tumor cells in the peripheral blood of colorectal cancer patients. Int J Color Dis. 2011;26(10):1265–70. https://doi.org/10.1007/s00384-011-1230-8.CrossRef

24.

Trachana V, van Wely KH, Guerrero AA, Futterer A, Martinez AC. Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability. Proc Natl Acad Sci U S A. 2007;104(8):2691–6. https://doi.org/10.1073/pnas.0611132104.CrossRefPubMedPubMedCentral

25.

Rojas AM, Sanchez-Pulido L, Futterer A, van Wely KH, Martinez AC, Valencia A. Death inducer obliterator protein 1 in the context of DNA regulation. Sequence analyses of distant homologues point to a novel functional role. FEBS J. 2005;272(14):3505–11. https://doi.org/10.1111/j.1742-4658.2005.04759.x.CrossRefPubMed

26.

Wang Y, Chen Y, Chen Z, Wu Q, Ke WJ, Wu QL. Gambogic acid induces death inducer-obliterator 1-mediated apoptosis in Jurkat T cells. Acta Pharmacol Sin. 2008;29(3):349–54. https://doi.org/10.1111/j.1745-7254.2008.00762.x.CrossRefPubMed

27.

Prieto I, Kouznetsova A, Futterer A, Trachana V, Leonardo E, Alonso Guerrero A, et al. Synaptonemal complex assembly and H3K4Me3 demethylation determine DIDO3 localization in meiosis. Chromosoma. 2009;118(5):617–32. https://doi.org/10.1007/s00412-009-0223-7.CrossRefPubMed

28.

Santiveri CM, Garcia-Mayoral MF, Perez-Canadillas JM, Jimenez MA. NMR structure note: PHD domain from death inducer obliterator protein and its interaction with H3K4me3. J Biomol NMR. 2013;56(2):183–90. https://doi.org/10.1007/s10858-013-9726-x.CrossRefPubMed

29.

Lee JH, Hart SR, Skalnik DG. Histone deacetylase activity is required for embryonic stem cell differentiation. Genesis. 2004;38(1):32–8. https://doi.org/10.1002/gene.10250.CrossRefPubMed

Titel: Role of DIDO1 in Progression of Esophageal Squamous Cell Carcinoma
verfasst von: Mohammad Mahdi Forghanifard
Pegah Naeimi Khorasanizadeh
Mohammad Reza Abbaszadegan
Afsaneh Javdani Mallak
Meysam Moghbeli
Publikationsdatum: 14.02.2019
Verlag: Springer US
Erschienen in: Journal of Gastrointestinal Cancer / Ausgabe 1/2020
Print ISSN: 1941-6628
Elektronische ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-019-00212-1

Springer Medizin

Role of DIDO1 in Progression of Esophageal Squamous Cell Carcinoma