Introduction
Methods
Search strategy
Eligibility criteria
Data extraction
Quality assessment
Statistical analysis
Results
References | Year | Country | Tumor type | Number of patients | Sex Male (+/−) Female (+/−) | Age older (+/−) middle aged (+/−) | HbsAg yes (+/−) no (+/−) | Liver cirrhosis yes (+/−) no (+/−) | AFP positive (+/−) negative (+/−) | Tumor size > 5 cm (+/−) ≤ 5 cm (+/−) | Tumor number single (+/−) multiple (+/−) | Vascular invasion yes (+/−) no (+/−) | Histological grade low (+/−) and moderate, high (+/−) | TNM stage I, II (+/−) III, IV (+/−) | Method | Cutoff | OS data provide | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Wu et al. (2014a) | 2014 | China | HCC | 156 | 113/30 | 55/18 | 93/24 | 86/26 | NA | 60/11 | 79/22 | 33/2 | 109/28 | 52/20 | IHC | 4 | Yes | |
11/2 | 69/14 | 31/8 | 38/6 | 64/21 | 45/10 | 91/30 | 15/4 | 72/12 | ||||||||||
Wu et al. (2014b) | 2014 | China | HCC | 150 | 52/74 | 18/58 | 4773 | 50/86 | NA | 52/54 | 48/20 | NA | 104/32 | 35/80 | IHC | 50% | Yes | |
3/21 | 37/92 | 8/22 | 5/9 | 3/44 | 55/95 | 20/15 | ||||||||||||
Xi et al. (2013) | 2013 | China | HCC | 125 | 58/50 | 34/30 | 61/45 | 46/41 | 42/14 | 30/19 | NA | 37/19 | 29/10 | 30/32 | IHC | 1 | Yes | |
10/7 | 34/27 | 7/12 | 22/16 | 26/43 | 38/38 | 31/38 | 39/47 | 38/25 | ||||||||||
Lee et al. (2013) | 2013 | Korea | HCC | 190 | 32/126 | 23/74 | 27/110 | 20/76 | 9/47 | 16/60 | NA | NA | 11/25 | 17/63 | IHC | 5 | No | |
8/24 | 17/76 | 13/40 | 20/74 | 31/103 | 24/90 | 29/125 | 23/87 | |||||||||||
Yu et al. (2018) | 2018 | China | HCC | 56 | 30/10 | 26/10 | 28/10 | NA | 23/7 | 25/7 | NA | NA | NA | NA | IHC | 4 | No | |
9/7 | 13/7 | 11/7 | 16/10 | 14/10 | ||||||||||||||
Li et al. (2018) | 2018 | China | HCC | 49 | 25/13 | 19/14 | 25/11 | NA | 16/10 | 20/9 | NA | 8/2 | 24/12 | 25/14 | IHC | 4 | No | |
6/5 | 12/4 | 6/7 | 15/8 | 11/9 | 23/16 | 7/6 | 6/4 | |||||||||||
Zhao et al. (2016) | 2016 | China | HCC | 52 | 13/22 | 11/16 | 17/30 | 15/25 | 16/24 | 10/23 | NA | 0/1 | 19/15 | 17/14 | IHC | 4 | No | |
8/9 | 10/15 | 4/1 | 6/6 | 5/7 | 13/6 | 21/30 | 2/16 | 4/17 | ||||||||||
Lu et al. (2012) | 2012 | China | HCC | 62 | 20/26 | 14/13 | 21/28 | NA | NA | NA | 22/24 | NA | 11/3 | 22/33 | IHC | 1 | No | |
9/9 | 13/22 | 6/7 | 5/11 | 16/32 | 6/3 | |||||||||||||
Song et al. (2014) | 2014 | China | HCC | 48 | 18/19 | 11/8 | 20/3 | 21/2 | NA | 9/12 | NA | 6/10 | 6/16 | 15/8 | IHC | 4 | No | |
5/6 | 17/12 | 22/3 | 24/1 | 14/13 | 17/15 | 17/9 | 8/17 | |||||||||||
Wu et al. (2016) | 2016 | China | HCC | 61 | 18/35 | 6/9 | 19/35 | 18/37 | NA | 18/27 | NA | 5/19 | 15/41 | NA | IHC | 1 | No | |
1/7 | 13/33 | 0/7 | 1/5 | 1/15 | 14/23 | 4/1 |
Study | Selection | Comparability | Outcome | Total score | |||||
---|---|---|---|---|---|---|---|---|---|
Exposed cohort | Non-exposed cohort | Ascertainment of exposure | Outcome of interest | Control for factor | Assessment of outcome | Follow-up long enough | Adequacy of follow-up | ||
Dong-Hao Wu | * | * | * | * | ** | * | * | * | 9 |
Wen-Yong Wu | * | * | * | * | ** | * | * | 8 | |
Shao-Yan Xi | * | * | * | * | ** | * | * | * | 9 |
Yoo Jin Lee | * | * | * | * | ** | * | * | * | 9 |
Yu Hai | * | * | * | * | ** | * | 7 | ||
Li Fang | * | * | * | * | ** | * | 7 | ||
Ya-Tong Zhao | * | * | * | * | * | * | * | * | 8 |
Yu-Dong Lu | * | * | * | * | ** | * | 7 | ||
Meng-Qi Song | * | * | * | * | * | * | 6 | ||
Wen-Yong Wu | * | * | * | * | * | * | * | * | 8 |
Meta-analysis of clinicopathological characteristics
Clinicopathological features | Number of studies | Number of patients | Pooled OR (95% CI) | Meta-regression p value | Heterogeneity | Model used | |
---|---|---|---|---|---|---|---|
p value | I2 (%) | ||||||
Gender | 10 | 949 | 1.13 (0.82, 1.56) | 0.452 | 0.820 | 0.0 | Fixed |
Age | 10 | 949 | 1.01 (0.80, 1.28) | 0.920 | 0.964 | 0.0 | Fixed |
HbsAg | 10 | 949 | 1.11 (0.83, 1.48) | 0.483 | 0.839 | 0.0 | Fixed |
AFP | 5 | 472 | 1.22 (0.85, 1.73) | 0.276 | 0.300 | 18.1 | Fixed |
Liver cirrhosis | 7 | 782 | 0.92 (0.68, 1.26) | 0.618 | 0.993 | 0.0 | Fixed |
Tumor size | 9 | 887 | 1.28 (1.00, 1.65) | 0.050 | 0.044 | 49.7 | Fixed |
Tumor number | 3 | 343 | 0.97 (0.67, 1.39) | 0.838 | 0.754 | 0.0 | Fixed |
Vascular invasion | 6 | 491 | 1.17 (0.84, 1.64) | 0.357 | 0.708 | 0.0 | Fixed |
Histological grade | 9 | 893 | 0.95 (0.70, 1.28) | 0.718 | 0.004 | 50.3 | Random |
TNM stage | 8 | 783 | 0.90 (0.70, 1.16) | 0.424 | 0.242 | 23.5 | Fixed |
Subgroup analysis
Subgroups | Number of studies | Number of patients | Pooled OR (95% CI) | p value | PHet | I2 (%) | Model used |
---|---|---|---|---|---|---|---|
Tumor size | |||||||
Sample | |||||||
n > 100 | 4 | 621 | 1.39 (1.02, 1.88) | 0.034 | 0.031 | 66.1 | Random |
n ≤ 100 | 5 | 218 | 1.09 (0.70, 1.69) | 0.697 | 0.166 | 38.2 | Fixed |
NOS score | |||||||
> 7 | 6 | 734 | 1.33 (1.00, 1.76) | 0.051 | 0.009 | 67.6 | Random |
≤ 7 | 3 | 105 | 1.15 (0.68, 1.95) | 0.610 | 0.753 | 0.0 | Fixed |
Area | |||||||
North | 2 | 246 | 1.13 (0.66, 1.92) | 0.662 | 0.600 | 0.0 | Fixed |
Midland | 4 | 311 | 1.73 (1.04, 2.88) | 0.035 | 0.001 | 81.2 | Random |
South | 3 | 330 | 1.17 (0.83, 1.66) | 0.364 | 0.964 | 0.0 | Fixed |
Average age | |||||||
≥ 55 | 5 | 506 | 1.81 (1.22, 2.70) | 0.003 | 0.036 | 61.0 | Random |
< 55 | 4 | 381 | 1.01 (0.73, 1.40) | 0.967 | 0.340 | 10.6 | Fixed |
Histological grade | |||||||
Sample | |||||||
n > 100 | 4 | 621 | 0.88 (0.60, 1.31) | 0.536 | 0.251 | 26.8 | Fixed |
n ≤ 100 | 5 | 272 | 1.05 (0.64, 1.71) | 0.843 | 0.017 | 66.9 | Random |
NOS score | |||||||
> 7 | 6 | 734 | 0.96 (0.67, 1.37) | 0.822 | 0.059 | 52.9 | Random |
≤ 7 | 3 | 159 | 0.91 (0.51, 1.62) | 0.746 | 0.065 | 63.3 | Random |
Area | |||||||
North | 2 | 252 | 0.94 (0.51, 1.75) | 0.854 | 0.035 | 77.5 | Random |
Midland | 4 | 311 | 1.51 (0.80, 2.86) | 0.206 | 0.033 | 65.7 | Random |
South | 3 | 330 | 0.76 (0.49, 1.16) | 0.205 | 0.596 | 0.0 | Fixed |
Average age | |||||||
≥ 55 | 4 | 450 | 0.95 (0.55, 1.64) | 0.859 | 0.230 | 30.3 | Fixed |
< 55 | 5 | 443 | 0.94 (0.65, 1.36) | 0.751 | 0.019 | 66.0 | Random |