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01.06.2012 | Nephrology - Original Paper

Roma ethnicity and clinical outcomes in kidney transplant recipients

verfasst von: Miklos Z. Molnar, Robert M. Langer, Adam Remport, Maria E. Czira, Katalin Rajczy, Kamyar Kalantar-Zadeh, Csaba P. Kovesdy, Marta Novak, Istvan Mucsi, Laszlo Rosivall

Erschienen in: International Urology and Nephrology | Ausgabe 3/2012

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Abstract

Background

Racial and ethnic disparities among North American patients with chronic kidney disease have received significant attention. In contrast, little is known about health-related outcomes of patients with end-stage renal disease among the Roma minority, also known as gypsies, compared to Caucasian individuals. We prospectively assessed the association between Roma ethnicity and long-term clinical outcomes in kidney transplant recipients.

Methods

In a prevalent cohort of renal transplant recipients, followed up over a median of 94 months, we prospectively collected socio-demographic, medical (and transplant related) characteristics and laboratory data at baseline from 60 Roma and 1,003 Caucasian patients (mean age 45 (SD = 11) and 49 (SD = 13) years, 33 and 41% women, 18 and 17% with diabetes mellitus, respectively). Survival analyses examined the associations between Roma ethnicity and all-cause mortality and death-censored graft loss or death with functioning renal allograft.

Results:

During the follow-up period, 341 patients (32%) died. Two-hundred eighty (26%) patients died with a functioning graft and 201 patients (19%) returned to dialysis. After multivariable adjustments, Roma ethnicity was associated with 77% higher risk of all-cause mortality (Hazard Ratio (HR): 1.77; 95% confidence interval (CI): 1.02, 3.07), two times higher risk of mortality with functioning graft (2.04 [1.17–3.55]) and 77% higher risk of graft loss (1.77 [1.01–3.13]), respectively.

Conclusions

Roma ethnicity is independently associated with increased mortality risk and worse graft outcome in kidney transplant recipients. Further studies should identify the factors contributing to worse outcomes among Roma patients.

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Titel: Roma ethnicity and clinical outcomes in kidney transplant recipients
verfasst von: Miklos Z. Molnar
Robert M. Langer
Adam Remport
Maria E. Czira
Katalin Rajczy
Kamyar Kalantar-Zadeh
Csaba P. Kovesdy
Marta Novak
Istvan Mucsi
Laszlo Rosivall
Publikationsdatum: 01.06.2012
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 3/2012
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-011-0088-6

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