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International Journal of Clinical Oncology

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27.03.2020 | Review Article

Salivary metabolites to detect patients with cancer: a systematic review

verfasst von: Daniele Xavier Assad, Elisa Cançado Porto Mascarenhas, Caroline Lourenço de Lima, Isabela Porto de Toledo, Hélène Chardin, Audrey Combes, Ana Carolina Acevedo, Eliete Neves Silva Guerra

Erschienen in: International Journal of Clinical Oncology | Ausgabe 6/2020

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Abstract

Novel adjunctive screening aids are needed to reduce the morbidity and mortality related to cancer, and every effort should be made for early diagnosis. This systematic review aimed to evaluate salivary metabolites and their diagnostic value in patients with cancer.

The systematic review was performed in two phases and included studies that focused on the diagnostic value of salivary metabolites in humans with solid malignant neoplasms. Five electronic databases were searched, and the risk of bias in individual studies was evaluated using the revised Quality Assessment of Diagnostic Accuracy Studies criteria (QUADAS-2). All procedures were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Of the 1151 studies retrieved, 25 were included; 13 studies used targeted and 12 untargeted metabolomics approaches. Most studies included patients with breast and oral cancer. Except for one, all studies had case–control designs, and none fulfilled all quality assessments. Overall, 140 salivary metabolites were described. The most frequently reported metabolites were alanine, valine, and leucine. Among the 11 studies that reported diagnostic test accuracy (DTA) values, proline, threonine, and histidine in combination and monoacylglycerol alone demonstrated the highest DTA for breast cancer. Combined choline, betaine, pipecolinic acid, and l-carnitine showed better discriminatory performance for early oral cancer.

This systematic review highlights the current evidence on salivary metabolites that may be used as a future strategy to diagnose cancer. Further studies including larger sample sizes with confirmation of the results by untargeted analysis are warranted.

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Titel: Salivary metabolites to detect patients with cancer: a systematic review
verfasst von: Daniele Xavier Assad
Elisa Cançado Porto Mascarenhas
Caroline Lourenço de Lima
Isabela Porto de Toledo
Hélène Chardin
Audrey Combes
Ana Carolina Acevedo
Eliete Neves Silva Guerra
Publikationsdatum: 27.03.2020
Verlag: Springer Singapore
Erschienen in: International Journal of Clinical Oncology / Ausgabe 6/2020
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-020-01660-7

Springer Medizin

Salivary metabolites to detect patients with cancer: a systematic review

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

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Springer Medizin

Abstract

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