Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
European Archives of Oto-Rhino-Laryngology
Erschienen in: European Archives of Oto-Rhino-Laryngology 4/2015

01.04.2015 | Review Article

Salivary mucoepidermoid carcinoma revisited

verfasst von: Andrés Coca-Pelaz, Juan P. Rodrigo, Asterios Triantafyllou, Jennifer L. Hunt, Alessandra Rinaldo, Primož Strojan, Missak Haigentz Jr., William M. Mendenhall, Robert P. Takes, Vincent Vander Poorten, Alfio Ferlito

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 4/2015

Einloggen, um Zugang zu erhalten

Abstract

Clinicopathological features, prognosis and therapeutic strategies for mucoepidermoid carcinoma originating in salivary and salivary-type glands of the head and neck are reviewed. We emphasise histopathological aspects, appraise the value of histochemistry, electron microscopy, immunohistochemistry and cytophotometry, and discuss histogenesis and characteristic gene translocations. We additionally consider possible diagnostic difficulties, problems related to histological grading and accuracy of existing literature, and areas of controversy or uncertainty which may benefit from further investigations.
Literatur
1.
Goode RK, El-Naggar AK (2005) Mucoepidermoid carcinoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC Press, Lyon, pp 219–220
2.
3.
Foote FW Jr, Frazell EL (1953) Tumors of the major salivary glands. Cancer 6:1065–1133PubMed
4.
Masson P, Berger L (1924) Epithélioma à double métaplasie de la parotide. Bull Ass Fr Étud Cancer 13:366–373
5.
Thackray AC, Lucas RB (1974) Tumors of the major salivary glands. Atlas of tumor pathology, 2nd series, fascicle 10. Armed Forces Institute of Pathology, Washington, DC, pp 16–39, 69–80
6.
Spiro RH (1986) Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg 8:177–184PubMed
7.
Ellis GL, Auclair P (1996) Tumors of the salivary glands. Atlas of tumor pathology, 3rd series, fascicle 17. Armed Forces Institute of Pathology, Washington, DC, pp 39–57, 155–175, 452–454
8.
Yoshida EJ, García J, Eisele DW, Chen AM (2014) Salivary gland malignancies in children. Int J Pediatr Otorhinolaryngol 78:174–178PubMed
9.
Eversole LR (1970) Mucoepidermoid carcinoma: review of 815 reported cases. J Oral Surg 28:490–494PubMed
10.
Goode RK, Auclair PL, Ellis GL (1998) Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer 82:1217–1224PubMed
11.
Melrose RJ, Abrams AM, Howell FV (1973) Mucoepidermoid tumors of the intraoral minor salivary glands: a clinicopathologic study of 54 cases. J Oral Pathol 2:314–325PubMed
12.
Woolgar JA, Triantafyllou A, Ferlito A, Devaney KO, Lewis JS Jr, Rinaldo A, Slootweg PJ, Barnes L (2013) Intraosseous carcinoma of the jaws: a clinicopathologic review. Part I: metastatic and salivary-type carcinomas. Head Neck 35:895–901PubMed
13.
Wolfish EB, Nelson BL, Thompson LDR (2012) Sinonasal tract mucoepidermoid carcinoma: a clinicopathologic and immunophenotypic study of 19 cases combined with a comprehensive review of the literature. Head Neck Pathol 6:191–207PubMedCentralPubMed
14.
Ferlito A, Recher G, Bottin R (1981) Mucoepidermoid carcinoma of the larynx. A clinicopathological study of 11 cases with review of the literature. ORL J Otorhinolaryngol Relat Spec 43:280–299PubMed
15.
Paulino AF, Huvos AG (1999) Epithelial tumors of the lacrimal glands: a clinicopathologic study. Ann Diagn Pathol 3:199–204PubMed
16.
Crain N, Nelson BL, Barnes EL, Thompson LDR (2009) Ceruminous gland carcinomas: a clinicopathologic and immunophenotypic study of 17 cases. Head Neck Pathol 3:1–17PubMedCentralPubMed
17.
Cameselle-Teijero J, Wenig B, Sobrinho-Simoes M, Albores-Saavedra J (2004) Mucoepidermoid carcinoma. In: DeLellis RA, Lloyd RV, Heitz PU, Eng C (eds) World Health Organization classification of tumours. Pathology and genetics of tumours of endocrine organs. IARC Press, Lyon, pp 82–83
18.
Plambeck K, Friedrich RE, Schmelzle R (1996) Mucoepidermoid carcinoma of salivary gland origin: classification, clinical-pathological correlation, treatment results and long-term follow-up in 55 patients. J Craniomaxillofac Surg 24:133–139PubMed
19.
Sharma P, Jain TK, Singh H, Suman SK, Faizi NA, Kumar R, Bal C, Malhotra A, Kumar R (2013) Utility of (18)F-FDG PET-CT in staging and restaging of patients with malignant salivary gland tumours: a single-institutional experience. Nucl Med Commun 34:211–219PubMed
20.
Klijanienko J, Vielh P (1997) Fine-needle sampling of salivary gland lesions. IV. Review of 50 cases of mucoepidermoid carcinoma with histologic correlation. Diagn Cytopathol 17:92–98PubMed
21.
Adelstein DJ, Koyfman SA, El-Naggar AK, Hanna EY (2012) Biology and management of salivary gland cancers. Semin Radiat Oncol 22:245–253PubMed
22.
Woolgar JA, Triantafyllou A (2011) Contemporary salivary clinical pathology: facts and dilemmas. In: Bradley PJ, Guntinas-Lichius O (eds) Salivary gland disorders and diseases: diagnosis and management. Thieme, Stuttgart, pp 27–41
23.
Chaudhry AP, Labay GR, Yamane GM, Jacobs MS, Cutler LS, Watkins KV (1984) Clinico-pathologic and histogenetic study of 189 intraoral minor salivary gland tumors. J Oral Med 39:58–78PubMed
24.
Seifert G (1991) Histological typing of salivary gland tumours of the salivary glands, 2nd edn. Springer, Berlin, pp 20–23, 70–74
25.
Dardick I (1996) Color atlas/text of salivary gland tumor pathology. Igaku-Shoin, New York, pp 163–177
26.
Cheuk W, Chan JK (2007) Salivary gland tumors. In: Fletcher CDM (ed) Diagnostic histopathology of tumors, 3rd edn. Churchill Livingstone Elsevier, Philadelphia, pp 239–325
27.
Simpson RHW, Di Palma S (2010) Selected recent advances in the pathology of salivary neoplasms. Diagn Histopathol 16:276–286
28.
Triantafyllou A, Hunt JL, Devaney KO, Ferlito A (2014) A perspective of comparative salivary and breast pathology. Part I: microstructural aspects, adaptations and cellular events. Eur Arch Otorhinolaryngol 271:647–663
29.
Brannon RB, Willard CC (2003) Oncocytic mucoepidermoid carcinoma of parotid gland origin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:727–733PubMed
30.
Weinreb I, Seethala RR, Perez-Ordoñez B, Chetty R, Hoschar AP, Hunt JL (2009) Oncocytic mucoepidermoid carcinoma: clinicopathologic description in a series of 12 cases. Am J Surg Pathol 33:409–416PubMed
31.
Sekine J, Anami M, Fujita S, Vieth M, Inokuchi T (2005) A case of mucoepidermoid carcinoma with melanin pigmentation manifested in the palate. Virchows Arch 446:460–462PubMed
32.
Woolgar JA, Triantafyllou A (2009) Pitfalls and procedures in the histopathological diagnosis of oral and oropharyngeal squamous cell carcinoma and a review of the role of pathology in prognosis. Oral Oncol 45:361–385PubMed
33.
Auclair PL (1994) Tumor-associated lymphoid proliferation in the parotid gland. A potential diagnostic pitfall. Oral Surg Oral Med Oral Pathol 77:19–26PubMed
34.
Veras EF, Sturgis E, Luna MA (2007) Sclerosing mucoepidermoid carcinoma of the salivary glands. Ann Diagn Pathol 11:407–412PubMed
35.
Tasaki T, Matsuyama A, Tabata T, Suzuki H, Yamada S, Sasaguri Y, Hisaoka M (2013) Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary gland: case report and review of the literature. Pathol Int 63:125–131PubMed
36.
Cheuk W, Chan JK (2007) Advances in salivary gland pathology. Histopathology 51:1–20PubMed
37.
Gassler N, Erbe M, Caselitz J, Donner A (2008) Mucoepidermoid carcinoma of palatinal glands with exuberant foreign-body giant cell reaction. Pathol Res Pract 204:689–691PubMed
38.
Kuo T, Tsang NM (2001) Salivary gland type nasopharyngeal carcinoma: a histologic, immunohistochemical, and Epstein-Barr virus study of 15 cases including a psammomatous mucoepidermoid carcinoma. Am J Surg Pathol 25:80–86PubMed
39.
Yang S, Chen X (2010) Calcifications in clear cell mucoepidermoid carcinomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:274–275PubMed
40.
Seifert G (1997) Karzinome in vorbestehenden Warthin-Tumoren (Zystadenolymphomen) der Parotis. Klassifikation. Pathogenese und Differentialdiagnose. Pathologe 18:359–367
41.
Woolgar JA, Triantafyllou A, Lewis JS Jr, Hunt J, Williams MD, Takes RP, Thompson LDR, Slootweg PJ, Devaney KO, Ferlito A (2013) Prognostic biological features in neck dissection specimens. Eur Arch Otorhinolaryngol 270:1581–1592PubMed
42.
Rodríguez-Cuevas S, Labastida S, Baena L, Gallegos F (1995) Risk of nodal metastases from malignant salivary gland tumors related to tumor size and grade of malignancy. Eur Arch Otorhinolaryngol 252:139–142PubMed
43.
Ettl T, Gosau M, Brockhoff G, Schwarz-Furlan S, Agaimy A, Reichert TE, Rohrmeier C, Zenk J, Iro H (2014) Predictors of cervical lymph node metastasis in salivary gland cancer. Head Neck 36:517–523
44.
Jakobsson PA, Blanck C, Eneroth CM (1968) Mucoepidermoid carcinoma of the parotid gland. Cancer 22:111–124PubMed
45.
Healey WV, Perzin KH, Smith L (1970) Mucoepidermoid carcinoma of salivary gland origin. Classification, clinical-pathologic correlation, and results of treatment. Cancer 26:368–388PubMed
46.
Batsakis JG, Luna MA (1990) Histopathologic grading of salivary gland neoplasms: I. Mucoepidermoid carcinomas. Ann Otol Rhinol Laryngol 99:835–838PubMed
47.
Auclair PL, Goode RK, Ellis GL (1992) Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation and application of grading criteria in 143 cases. Cancer 69:2021–2030PubMed
48.
Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, Bodian C, Urken ML, Gnepp DR, Huvos A, Lumerman H, Mills SE (2001) Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol 25:835–845PubMed
49.
Woolgar JA, Triantafyllou A (2011) Squamous cell carcinoma and precursor lesions: clinical pathology. Periodontol 2000 57:51–72PubMed
50.
Chenevert J, Barnes LE, Chiosea SI (2011) Mucoepidermoid carcinoma: a five-decade journey. Virchows Arch 458:133–140PubMed
51.
Okumura Y, Miyabe S, Nakayama T, Fujiyoshi Y, Hattori H, Shimozato K, Inagaki H (2011) Impact of CRTC1/3-MAML2 fusions on histological classification and prognosis of mucoepidermoid carcinoma. Histopathology 59:90–97PubMed
52.
Nagao T, Gaffey TA, Kay PA, Unni KK, Nascimento AG, Sebo TJ, Serizawa H, Minato H, Lewis JE (2003) Dedifferentiation in low-grade mucoepidermoid carcinoma of the parotid gland. Hum Pathol 34:1068–1072PubMed
53.
Eversole LR (1972) Glycoprotein heterogeneity in mucoepidermoid carcinoma. A histochemical evaluation. Arch Otolaryngol 96:426–432PubMed
54.
Triantafyllou A, Fletcher D, Scott J (1999) Morphological phenotypes and functional capabilities of submandibular parenchymal cells of the ferret investigated by protein, mucosubstance and enzyme histochemistry. Histochem J 31:789–796PubMed
55.
Triantafyllou A (1986) Histochemical study of mucosubstances of mucoepidermoid tumor. Tinctorial behaviour to aldehyde fuchsin before and after treatment with monopersulfate acid. Materia Medica Greca 14:459–467
56.
Hassanin MB, Ghosh L, Das AK, Waterhouse JP (1989) Immunohistochemical and fluorescent microscopic study of histogenesis of salivary mucoepidermoid carcinoma. J Oral Pathol Med 18:291–298PubMed
57.
Triantafyllou A, Eleftheriadis E, Martis C (1989) Histochemical study of the biphasic cellular pattern of tubular adenoid cystic carcinoma with azophloxine, amidoblack and acid blue. Ann Dent 48:20–24PubMed
58.
Fletcher D, Triantafyllou A, Scott J (1999) Innervation and myoepithelial arrangements in the submandibular salivary gland of ferret investigated by enzyme, catecholamine and filament histochemistry. Arch Oral Biol 44:1035–1043PubMed
59.
Takeda Y, Kurose A (2006) Pigmented mucoepidermoid carcinoma, a case report and review of the literature on melanin-pigmented salivary gland tumors. J Oral Sci 48:253–256PubMed
60.
Chen SY (1979) Ultrastructure of mucoepidermoid carcinoma in minor salivary glands. Oral Surg Oral Med Oral Pathol 47:247–255PubMed
61.
Chaudhry AP, Cutler LS, Leifer C, Labay G, Satchidanand S, Yamane GM (1989) Ultrastructural study of the histogenesis of salivary gland mucoepidermoid carcinoma. J Oral Pathol Med 18:400–409PubMed
62.
Dardick I, Daya D, Hardie J, van Nostrand AW (1984) Mucoepidermoid carcinoma: ultrastructural and histogenetic aspects. J Oral Pathol 13:342–358PubMed
63.
Dardick I, Gliniecki MR, Heathcote JG, Burford-Mason A (1990) Comparative histogenesis and morphogenesis of mucoepidermoid carcinoma and pleomorphic adenoma. An ultrastructural study. Virchows Arch A Pathol Anat Histopathol 417:405–417PubMed
64.
Foschini MP, Marucci G, Eusebi V (2002) Low-grade mucoepidermoid carcinoma of salivary glands: characteristic immunohistochemical profile and evidence of striated duct differentiation. Virchows Arch 440:536–542PubMed
65.
Sobral AP, Loducca SV, Nunes FD, de Araújo NS, Kowalski LP, de Araújo VC (2004) Relationship between major and minor salivary gland mucoepidermoid carcinoma malignancy grading and presence of stromal myofibroblasts: immunohistochemical study. J Oral Pathol Med 33:335–339PubMed
66.
Sidhu GS, Waldo ED (1975) Oncocytic change in mucoepidermoid carcinoma of the parotid gland. Arch Pathol 99:663–666PubMed
67.
Marucci G, Marchetti C, Betts CM, Foschini MP (2005) Pigmented mucoepidermoid carcinoma of the oral cavity: a case report. Int J Surg Pathol 13:295–297PubMed
68.
Loyola AM, de Sousa SO, Araújo NS, Araújo VC (1998) Study of minor salivary gland mucoepidermoid carcinoma differentiation based on immunohistochemical expression of cytokeratins, vimentin and muscle-specific actin. Oral Oncol 34:112–118PubMed
69.
Azevedo RS, de Almeida OP, Kowalski LP, Pires FR (2008) Comparative cytokeratin expression in the different cell types of salivary gland mucoepidermoid carcinoma. Head Neck Pathol 2:257–264PubMedCentralPubMed
70.
Butler RT, Spector ME, Thomas D, McDaniel AS, McHugh JB (2013) An immunohistochemical panel for reliable differentiation of salivary duct carcinoma and mucoepidermoid carcinoma. Head Neck Pathol (Epub ahead of print)
71.
Huang JW, Mori M, Yamada K, Isono K, Ueno K, Shinohara M, Harada T, Oka M (1992) Mucoepidermoid carcinoma of the salivary glands: immunohistochemical distribution of intermediate filament proteins, involucrin and secretory proteins. Anticancer Res 12:811–820PubMed
72.
Hamper K, Schmitz-Wätjen W, Mausch HE, Caselitz J, Seifert G (1989) Multiple expression of tissue markers in mucoepidermoid carcinomas and acinic cell carcinomas of the salivary glands. Virchows Arch A Pathol Anat Histopathol 414:407–413PubMed
73.
Ruggles N, Triantafyllou A (2013) Lysosomal activities and cellular homeostasis in epithelial tumours of salivary glands: an immunohistochemical investigation. J Pathol 231:S34
74.
Vanmuylder N, Evrard L, Daelemans P, Douroy N (2000) Chaperones in the parotid gland: localization of heat shock proteins in human adult salivary glands. Cells Tissues Organs 167:199–205PubMed
75.
Therkildsen MH, Mandel U, Christensen M, Dabelsteen E (1993) Simple mucin-type Tn and sialosyl-Tn carbohydrate antigens in salivary gland carcinomas. Cancer 72:1147–1154PubMed
76.
Alos L, Lujan B, Castillo M, Nadal A, Carreras M, Caballero M, de Bolos C, Cardesa A (2005) Expression of membrane-bound mucins (MUC1 and MUC4) and secreted mucins (MUC2, MUC5AC, MUC5B, MUC6 and MUC7) in mucoepidermoid carcinomas of salivary glands. Am J Surg Pathol 29:806–813PubMed
77.
Handra-Luca A, Lamas G, Bertrand JC, Fouret P (2005) MUC1, MUC2, MUC4, and MUC5AC expression in salivary gland mucoepidermoid carcinoma: diagnostic and prognostic implications. Am J Surg Pathol 29:881–889PubMed
78.
Triantafyllou A (2001) Acinar phenotypes in salivary pleomorphic adenoma: unusual differentiation or disordered functional activity? Pathol Res Pract 197:743–751PubMed
79.
Kumasa S, Yuba R, Sagara S, Okutomi T, Okada Y, Mori M (1988) Mucoepidermoid carcinomas: immunohistochemical studies on keratin, S-100 protein, lactoferrin, lysozyme and amylase. Basic Appl Histochem 32:429–441PubMed
80.
Okamura K, Kiyoshima T, Shima K, Kobayashi I, Matsuo K, Ishibashi H, Komatsu S, Rasul AM, Sakai H (2002) Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland. Oral Oncol 38:244–250PubMed
81.
Aro K, Rosa LE, Bello IO, Soini Y, Mäkitie AA, Salo T, Leivo I (2011) Expression pattern of claudins 1 and 3—an auxiliary tool in predicting behavior of mucoepidermoid carcinoma of salivary gland origin. Virchows Arch 458:341–348PubMed
82.
Economopoulou P, Hanby A, Odell EW (2000) Expression of E-cadherin, cellular differentiation and polarity in epithelial salivary neoplasms. Oral Oncol 36:515–518PubMed
83.
Tian W, Yakirevich E, Matoso A, Gnepp DR (2012) IgG4(+) plasma cells in sclerosing variant of mucoepidermoid carcinoma. Am J Surg Pathol 36:973–979PubMed
84.
Shieh YS, Hung YJ, Hsieh CB, Chen JS, Chou KC, Liu SY (2009) Tumor-associated macrophage correlated with angiogenesis and progression of mucoepidermoid carcinoma of salivary glands. Ann Surg Oncol 16:751–760PubMed
85.
Larsen SR, Bjørndal K, Godballe C, Krogdahl A (2012) Prognostic significance of Ki-67 in salivary gland carcinomas. J Oral Pathol Med 41:598–602PubMed
86.
Skalova A, Lehtonen H, von Boguslawsky K, Leivo I (1994) Prognostic significance of cell proliferation in mucoepidermoid carcinomas of the salivary gland: clinicopathological study using MIB 1 antibody in paraffin sections. Hum Pathol 25:929–935PubMed
87.
Yin HF, Okada N, Takagi M (2000) Apoptosis and apoptotic-related factors in mucoepidermoid carcinoma of the oral minor salivary glands. Pathol Int 50:603–609PubMed
88.
Zyada MM, Grawish ME, Elsabaa HM (2009) Predictive value of cyclooxygenase 2 and Bcl-2 for cervical lymph node metastasis in mucoepidermoid carcinoma. Ann Diagn Pathol 13:313–321PubMed
89.
Yamada K, Iwai K, Okada Y, Mori M (1989) Immunohistochemical expression of epidermal growth factor receptor in salivary gland tumours. Virchows Arch A Pathol Anat Histopathol 415:523–531PubMed
90.
Lujan B, Hakim S, Moyano S, Nadal A, Caballero M, Diaz A, Valera A, Carrera M, Cardesa A, Alos L (2010) Activation of the EGFR/ERK pathway in high-grade mucoepidermoid carcinomas of the salivary glands. Br J Cancer 103:510–516PubMedCentralPubMed
91.
Suzuki S, Dobashi Y, Minato H, Tajiri R, Yoshizaki T, Ooi A (2012) EGFR and HER2-Akt-mTOR signaling pathways are activated in subgroups of salivary gland carcinomas. Virchows Arch 461:271–282PubMed
92.
Press MF, Pike MC, Hung G, Zhou JY, Ma Y, George J, Dietz-Band J, James W, Slamon DJ, Batsakis JG, El-Naggar AK (1994) Amplification and overexpression of HER-2/neu in carcinomas of the salivary gland: correlation with poor prognosis. Cancer Res 54:5675–5682PubMed
93.
Clauditz TS, Reiff M, Gravert L, Gnoss A, Tsourlakis MC, Münscher A, Sauter G, Bokemeyer C, Knecht R, Wilczak W (2011) Human epidermal growth factor receptor 2 (HER2) in salivary gland carcinomas. Pathology 43:459–463PubMed
94.
Nakano T, Yamamoto H, Hashimoto K, Tamiya S, Shiratsuchi H, Nakashima T, Nishiyama K, Higaki Y, Komune S, Oda Y (2013) HER2 and EGFR gene copy number alterations are predominant in high-grade salivary mucoepidermoid carcinoma irrespective of MAML2 fusion status. Histopathology 63:378–392PubMed
95.
Dillard DG, Muller S, Cohen C, Bloch D, Del Gaudio JM, Gal AA (2001) High tumor grade in salivary gland mucoepidermoid carcinomas and loss of expression of transforming growth factor beta receptor type II. Arch Otolaryngol Head Neck Surg 127:683–686PubMed
96.
Myoken Y, Myoken Y, Okamoto T, Sato JD, Kan M, McKeehan WL, Nakahara M, Takada K (1996) Immunohistochemical study of overexpression of fibroblast growth factor-1 (FGF-1), FGF-2, and FGF receptor-1 in human malignant salivary gland tumours. J Pathol 178:429–436PubMed
97.
Demasi AP, Silva CA, Silva AD, Furuse C, Soares AB, Altemani A, Napimoga MH, Araújo VC (2012) Expression of the vascular endothelial growth factor and angiopoietins in mucoepidermoid carcinoma of salivary gland. Head Neck Pathol 6:101–105
98.
Piludu M, Lantini MS, Isola M, Lecca F, Cossu M (2002) Ultrastructural localization of epidermal growth factor receptor in human parotid gland. Eur J Morphol 40:213–217PubMed
99.
Nagel H, Laskawi R, Wahlers A, Hemmerlein B (2004) Expression of matrix metalloproteinases MMP-2, MMP-9 and their tissue inhibitors TIMP-1, -2, and -3 in benign and malignant tumours of the salivary gland. Histopathology 44:222–231PubMed
100.
Kayano K, Shimada T, Shinomiya T, Nakai S, Hisa Y, Aoki T, Seiki M, Okada Y (2004) Activation of pro-MMP-2 mediated by MT1-MMP in human salivary gland carcinomas: possible regulation of pro-MMP-2 activation by TIMP-2. J Pathol 202:403–411PubMed
101.
Brunner M, Koperek O, Wrba F, Erovic BM, Heiduschka G, Schoppper C, Thurnher D (2012) HPV infection and p16 expression in carcinomas of the minor salivary glands. Eur Arch Otorhinolaryngol 269:2265–2269PubMed
102.
Jour G, West K, Ghali V, Shank D, Ephrem G, Wenig BM (2013) Differential expression of p16(INK4A) and cyclin D1 in benign and malignant salivary gland tumors: a study of 44 Cases. Head Neck Pathol 7:224–231PubMedCentralPubMed
103.
Isayeva T, Said-Al-Naief N, Ren Z, Li R, Gnepp D, Brandwein-Gensler M (2013) Salivary mucoepidermoid carcinoma: demonstration of transcriptionally active human papillomavirus 16/18. Head Neck Pathol 7:135–148PubMedCentralPubMed
104.
Melnick M, Sedghizadeh PP, Allen CM, Jaskoll T (2012) Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship. Exp Mol Pathol 92:118–125PubMed
105.
Kiyoshima T, Shima K, Kobayashi I, Matsuo K, Okamura K, Komatsu S, Rasul AM, Sakai H (2001) Expression of p53 tumor suppressor gene in adenoid cystic and mucoepidermoid carcinomas of the salivary glands. Oral Oncol 37:315–322PubMed
106.
Soini Y, Kamel D, Nuorva K, Lane DP, Vähäkangas K, Pääkkö P (1992) Low p53 protein expression in salivary gland tumours compared with lung carcinomas. Virchows Arch A Pathol Anat Histopathol 421:415–420PubMed
107.
Ishii K, Nakajima T (1994) Evaluation of malignant grade of salivary gland tumors: studies by cytofluorometric nuclear DNA analysis, histochemistry for nucleolar organizer regions and immunohistochemistry for p53. Pathol Int 44:287–296PubMed
108.
Gallo O, Franchi A, Bianchi S, Boddi V, Giannelli E, Alajmo E (1995) p53 oncoprotein expression in parotid gland carcinoma is associated with clinical outcome. Cancer 75:2037–2044PubMed
109.
Kamio N (1996) Coexpression of p53 and c-erbB-2 proteins is associated with histological type, tumour stage, and cell proliferation in malignant salivary gland tumours. Virchows Arch 428:75–78PubMed
110.
Kärjä VJ, Syrjänen KJ, Kurvinen AK, Syrjänen SM (1997) Expression and mutations of p53 in salivary gland tumours. J Oral Pathol Med 26:217–223PubMed
111.
Shi L, Chen XM, Wang L, Zhang L, Chen Z (2007) Expression of caveolin-1 in mucoepidermoid carcinoma of the salivary glands: correlation with vascular endothelial growth factor, microvessel density, and clinical outcome. Cancer 109:1523–1531PubMed
112.
Sams RN, Gnepp DR (2013) P63 expression can be used in differential diagnosis of salivary gland acinic cell and mucoepidermoid carcinomas. Head Neck Pathol 7:64–68PubMedCentralPubMed
113.
Chiosea SI, Barnes EL, Lai SY, Egloff AM, Sargent RL, Hunt JL, Seethala RR (2008) Mucoepidermoid carcinoma of upper aerodigestive tract: clinicopathologic study of 78 cases with immunohistochemical analysis of Dicer expression. Virchows Arch 452:629–635PubMed
114.
Handra-Luca A, Bilal H, Bertrand JC, Fouret P (2003) Extra-cellular signal-regulated ERK-1/ERK-2 pathway activation in human salivary gland mucoepidermoid carcinoma: association to aggressive tumor behavior and tumor cell proliferation. Am J Pathol 163:957–967PubMedCentralPubMed
115.
Hamper K, Schimmelpenning H, Caselitz J, Arps H, Berger J, Askensten U, Auer G, Seifert G (1989) Mucoepidermoid tumors of the salivary glands. Correlation of cytophotometrical data and prognosis. Cancer 63:708–717PubMed
116.
Hicks MJ, El-Naggar AK, Flaitz CM, Luna MA, Batsakis JG (1995) Histocytologic grading of mucoepidermoid carcinoma of major salivary glands in prognosis and survival: a clinicopathologic and flow cytometric investigation. Head Neck 17:89–95PubMed
117.
Pires FR, Azevedo RS, Ficarra G, Cardoso AS, Carlos R, Kowalski LP, de Almeida OP (2010) Metastatic renal cell carcinoma to the oral cavity and clear cell mucoepidermoid carcinoma: comparative clinicopathologic and immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:e22–e27PubMed
118.
Woolgar JA, Triantafyllou A, Thompson LDR, Hunt JL, Lewis JS Jr, Williams MD, Cardesa A, Rinaldo A, Barnes L, Slootweg PJ, Devaney KO, Gnepp DR, Westra WH, Ferlito A (2014) Double reporting and second opinion in head and neck pathology. Eur Arch Otorhinolaryngol 271:847–854
119.
Eversole LR (1971) Histogenic classification of salivary tumors. Arch Pathol 92:433–443PubMed
120.
Batsakis JG (1980) Salivary gland neoplasia: an outcome of modified morphogenesis and cytodifferentiation. Oral Surg Oral Med Oral Pathol 49:229–232PubMed
121.
Glisson B, Colevas AD, Haddad R, Krane J, El-Naggar A, Kies M, Costello R, Summey C, Arquette M, Langer C, Amrein PC, Posner M (2004) HER2 expression in salivary gland carcinomas: dependence on histological subtype. Clin Cancer Res 10:944–946PubMed
122.
Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O’Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye F (2003) t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet 33:208–213PubMed
123.
Hunt JL (2011) An update on molecular diagnostics of squamous and salivary gland tumors of the head and neck. Arch Pathol Lab Med 135:602–609PubMed
124.
Weinreb I (2013) Translocation-associated salivary gland tumors: a review and update. Adv Anat Pathol 20:367–377PubMed
125.
Martins C, Cavaco B, Tonon G, Kaye FJ, Soares J, Fonseca I (2004) A study of MECT1-MAML2 in mucoepidermoid carcinoma and Warthin’s tumor of salivary glands. J Mol Diagn 6:205–210PubMedCentralPubMed
126.
Behboudi A, Enlund F, Winnes M, Andrén Y, Nordkvist A, Leivo I, Flaberg E, Szekely L, Mäkitie A, Grenman R, Mark J, Stenman G (2006) Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. Genes Chromosomes Cancer 45:470–481PubMed
127.
Bell D, El-Naggar AK (2013) Molecular heterogeneity in mucoepidermoid carcinoma: conceptual and practical implications. Head Neck Pathol 7:23–27PubMedCentralPubMed
128.
Seethala RR, Dacic S, Cieply K, Kelly LM, Nikiforova MN (2010) A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas. Am J Surg Pathol 34:1106–1121PubMed
129.
García JJ, Hunt JL, Weinreb I, McHugh JB, Barnes EL, Cieply K, Dacic S, Seethala RR (2011) Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic test. Hum Pathol 42:2001–2009PubMed
130.
Anzick SL, Chen WD, Park Y, Meltzer P, Bell D, El-Naggar AK, Kaye FJ (2010) Unfavorable prognosis of CRTC1-MAML2 positive mucoepidermoid tumors with CDKN2A deletions. Genes Chromosomes Cancer 49:59–69PubMedCentralPubMed
131.
McHugh CH, Roberts DB, El-Naggar AK, Hanna EY, Garden AS, Kies MS, Weber RS, Kupferman ME (2012) Prognostic factors in mucoepidermoid carcinoma of the salivary glands. Cancer 118:3928–3936PubMed
132.
Chen MM, Roman SA, Sosa JA, Judson BL (2014) Histologic grade as prognostic indicator for mucoepidermoid carcinoma: a population-level analysis of 2400 patients. Head Neck 36:158–163PubMed
133.
Nance MA, Seethala RR, Wang Y, Chiosea SI, Myers EN, Johnson JT, Lai SY (2008) Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma. Cancer 113:2082–2089PubMedCentralPubMed
134.
Vander Poorten V, Hunt J, Bradley PJ, Haigentz M Jr, Rinaldo A, Mendenhall WM, Suárez C, Silver C, Takes RP, Ferlito A (2014) Recent trends in the management of minor salivary gland carcinoma. Head Neck 36:444–455
135.
Garden AS, El-Naggar AK, Morrison WH, Callender DL, Ang KK, Peters LJ (1997) Postoperative radiotherapy for malignant tumors of the parotid gland. Int J Radiat Oncol Biol Phys 37:79–85PubMed
136.
Terhaard CH, Lubsen H, Van der Tweel I, Hilgers FJ, Eijkenboom WM, Marres HA, Tjho-Heslinga RE, de Jong JM, Roodenburg JL (2004) Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch Head and Neck Oncology Cooperative Group. Head Neck 26:681–693PubMed
137.
Chen AM, Lau VH, Farwell DG, Luu Q, Donald PJ (2013) Mucoepidermoid carcinoma of the parotid gland treated by surgery and postoperative radiation therapy: clinicopathologic correlates of outcome. Laryngoscope 123:3049–3055PubMed
138.
Byrd SA, Spector ME, Carey TE, Bradford CR, McHugh JB (2013) Predictors of recurrence and survival for head and neck mucoepidermoid carcinoma. Otolaryngol Head Neck Surg 149:402–408PubMedCentralPubMed
139.
Jarvis SJ, Giangrande V, Brennan PA (2013) Mucoepidermoid carcinoma of the tonsil: a very rare presentation. Acta Otorhinolaryngol Ital 33:286–288PubMedCentralPubMed
140.
Chung JH, Lee SH, Park CW, Tae K (2012) Mucoepidermoid carcinoma in the external auditory canal: a case report. Cancer Res Treat 44:275–278PubMedCentralPubMed
141.
Armstrong JG, Harrison LB, Thaler HT, Friedlander-Klar H, Fass DE, Zelefsky MJ, Shah JP, Strong EW, Spiro RH (1992) The indications for elective treatment of the neck in cancer of the major salivary glands. Cancer 69:615–619PubMed
142.
Hosokawa Y, Shirato H, Kagei K, Hashimoto S, Nishioka T, Tei K, Ono M, Ohmori K, Kaneko M, Miyasaka K, Nakamura M (1999) Role of radiotherapy for mucoepidermoid carcinoma of salivary gland. Oral Oncol 35:105–111PubMed
143.
Ghosh-Laskar S, Murthy V, Wadasadawala T, Agarwal J, Budrukkar A, Patil N, Kane S, Chaukar D, Pai P, Chaturvedi P, D’Cruz A (2011) Mucoepidermoid carcinoma of the parotid gland: factors affecting outcome. Head Neck 33:497–503PubMed
144.
Chen AM, Granchi PJ, Garcia J, Bucci MK, Fu KK, Eisele DW (2007) Local-regional recurrence after surgery without postoperative irradiation for carcinomas of the major salivary glands: implications for adjuvant therapy. Int J Radiat Oncol Biol Phys 67:982–987PubMed
145.
Chen AM, Garcia J, Lee NY, Bucci MK, Eisele DW (2007) Patterns of nodal relapse after surgery and postoperative radiation therapy for carcinomas of the major and minor salivary glands: what is the role of elective neck irradiation? Int J Radiat Oncol Biol Phys 67:988–994PubMed
146.
Gilbert J, Li Y, Pinto HA, Jennings T, Kies MS, Silverman P, Forastiere AA (2006) Phase II trial of taxol in salivary gland malignancies (E1394): a trial of the Eastern Cooperative Oncology Group. Head Neck 28:197–204PubMed
147.
Venook AP, Tseng A Jr, Meyers FJ, Silverberg I, Boles R, Fu KK, Jacobs CD (1987) Cisplatin, doxorubicin and 5-fluorouracil chemotherapy for salivary gland malignancies: a pilot study of the Northern California Oncology Group. J Clin Oncol 5:951–955PubMed
148.
Laurie SA, Licitra L (2006) Systemic therapy in the palliative management of advanced salivary gland cancers. J Clin Oncol 24:2673–2678PubMed
149.
Haddad R, Colevas AD, Krane JF, Cooper D, Glisson B, Amrein PC, Weeks L, Costello R, Posner M (2003) Herceptin in patients with advanced or metastatic salivary gland carcinomas. A phase II study. Oral Oncol 39:724–727PubMed
150.
Lee HE, Choi ES, Shin JA, Lee SO, Park KS, Cho NP, Cho SD (2014) Fucoidan induces caspase-dependent apoptosis in MC3 human mucoepidermoid carcinoma cells. Exp Ther Med 7:228–232PubMedCentralPubMed
Metadaten
Titel
Salivary mucoepidermoid carcinoma revisited
verfasst von
Andrés Coca-Pelaz
Juan P. Rodrigo
Asterios Triantafyllou
Jennifer L. Hunt
Alessandra Rinaldo
Primož Strojan
Missak Haigentz Jr.
William M. Mendenhall
Robert P. Takes
Vincent Vander Poorten
Alfio Ferlito
Publikationsdatum
01.04.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 4/2015
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-014-3053-z

Weitere Artikel der Ausgabe 4/2015

European Archives of Oto-Rhino-Laryngology 4/2015 Zur Ausgabe

Head and Neck

Value of sentinel lymph node biopsy in papillary thyroid cancer: initial results of a prospective trial

Review Article

Inflammatory myofibroblastic tumors of the nasal cavity and paranasal sinus: a clinicopathologic study of 25 cases and review of the literature

Erratum

Erratum to: The significance of osteitis in rhinosinusitis

Obituary

The father of Osseointegration and the godfather of the BAHA: Professor Per-Ingvar Brånemark, Göteborg Sweden has passed away in his 86th year

Rhinology

Ultrasonography Findings in Nasal Bone Fracture; 6-Month Follow-up: Can We Estimate Time of Trauma?

Miscellaneous

The effects of oropharyngeal–lingual exercises in patients with primary snoring

Neu im Fachgebiet HNO

Kinder mit anhaltender Sinusitis profitieren häufig von Antibiotika

30.04.2024 Rhinitis und Sinusitis Nachrichten

Persistieren Sinusitisbeschwerden bei Kindern länger als zehn Tage, ist eine Antibiotikatherapie häufig gut wirksam: Ein Therapieversagen ist damit zu über 40% seltener zu beobachten als unter Placebo.

CUP-Syndrom: Künstliche Intelligenz kann Primärtumor finden

30.04.2024 Künstliche Intelligenz Nachrichten

Krebserkrankungen unbekannten Ursprungs (CUP) sind eine diagnostische Herausforderung. KI-Systeme können Pathologen dabei unterstützen, zytologische Bilder zu interpretieren, um den Primärtumor zu lokalisieren.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen
Bildnachweise