nach oben

Neurological Sciences

Erschienen in:

02.03.2022 | Original Article

Sensitivity and specificity of pupillary light reflex measures for ASD using monocular pupillometry

verfasst von: Georgina T. F. Lynch, Stephen M. James, Teresa A. Cardon, Sterling M. McPherson

Erschienen in: Neurological Sciences | Ausgabe 7/2022

Einloggen, um Zugang zu erhalten

Abstract

Introduction

Automated hand-held pupillometry demonstrates precision accuracy, offering promise for augmenting ASD screening.

Methods

Monocular pupillometry was examined in children and adolescents (36 ASD; 24 TD). Multiple logistic regression and receiver operating characteristic analysis assessed PLR metrics and diagnostic status.

Results

Constriction time (Ct₁) (ASD: M = 0.69, SD = 0.21; TD: M = 0.82, SD = 0.18; t(58 = 2.37; p = 0.02) and return to baseline (RTB T75) (ASD: M = 2.93, SD = 1.21; TD: M = 2.32, SD = 1.08; t(58) = − 2.03; p = 0.04) predicted ASD (β = − 1.31, OR = 0.27; RTB T75, β = 0.156, OR = 1.162). Sensitivity = 74.8%, when RTB ≥ 1.83 s and 69.4% when Ct₁ = 0.785 s.

Conclusion

Findings suggest monocular pupillometry captures differences detecting ASD.

Nur mit Berechtigung zugänglich

American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders (DSM-5). American Psychiatric Association. Author

Shattuck PT, Durkin M, Maenner M, Newschaffer C, Mandell DS, Wiggins L, ... Cuniff C (2009) Timing of identification among children with an autism spectrum disorder: findings from a population-based surveillance study. J Amer Academy Child & Adolesc Psychiatry 48(5):474-483

Johnson CP, Myers SM (2007) Identification and evaluation of children with autism spectrum disorders. Pediatrics 120(5):1183–1215CrossRef

American Academy of Pediatrics (2010) Clinical report: identification and evaluation of children with autism spectrum disorders. Pediatrics 120(5):1183–1215. Reaffirmed September 2010. https://doi.org/10.1542/peds.2010-2549

Guthrie W, Wallis K, Bennett A, Brooks E, Dudley J, Gerdes M, Pandey J, Levy S, Schultz R, Miller JS (2019) Accuracy of autism screening in a large pediatric network. Pediatrics, 144(4). https://doi.org/10.1542/peds.2018-3963

Centers for Disease Control (2019) Screening and diagnosis of autism spectrum disorder.: https://www.cdc.gov/ncbddd/autism/screening.html

Morris R, Greenblatt A, Saini M (2019) Healthcare providers’ experiences with autism: a scoping review. J Autism Dev Disorders 49(6):2374–2388. https://doi.org/10.1007/10803-019-03912-6CrossRef

Daluwatte, Chathuri, Miles, J.H., Christ, S.E., Beversdorf, D.Q., Takahashi, N., & Yao, G. (2013) Atypical pupillary light reflex and heart rate variability in children with autism spectrum disorder. J Autism Dev Disorders 43(8):1910–1925. https://link.springer.com/article/10.1007%2Fs10803-012-1741-3

Fan, X., Miles, J. H., Takahashi, N., & Yao, G. (2009). Abnormal transient pupillary light reflex in individuals with autism spectrum disorders. J Autism Dev Disorders 39(11):1499–1508. https://link.springer.com/article/10.1007%252Fs10803-009-0767-7

10.

Lynch GT, James SM, VanDam M (2018) Pupillary response and phenotype in ASD: Latency to constriction discriminates ASD from typically developing adolescents. Autism Res 11(2):364–375. https://doi.org/10.1002/aur.1888CrossRefPubMed

11.

Nyström P, Gliga T, Jobs EN, Gredebäck G, Charman T, Johnson MH, Bölte S, Falck-Ytter T (2018) Enhanced pupillary light reflex in infancy is associated with autism diagnosis in toddlerhood. Nature Comm 9(1):1–5. https://doi.org/10.1038/s41467-018-03985-4CrossRef

12.

Bremner F (2009) Pupil evaluation as a test for autonomic disorders. Clinical Autonomic Res 19(2):88–101CrossRef

13.

Larsen RS, Waters J (2018) Neuromodulatory correlates of pupil dilation. Frontiers in Neural Circuits 12, 21. https://doi.org/10.3389/fncir.2018.00021/full

14.

Lowenstein O, Loewenfeld IE (1950) Role of sympathetic and parasympathetic systems in reflex dilation of the pupil. Arch Neurol Psychiatry 64:314–340. https://doi.org/10.1001/archneurpsyc.1950.02310270002001CrossRef

15.

Steinhauer SR, Siegle GJ, Condray R, Pless M (2004) Sympathetic and parasympathetic innervation of pupillary dilation during sustained processing. Int J Psychophysiol 52(1):77–86. https://doi.org/10.1016/j.ijpsycho.2003.12.005CrossRefPubMed

16.

Jones W, Klin A (2013) Attention to eyes is present but in decline in 2–6-month-old infants later diagnosed with autism. Nature 504(7480):427. https://doi.org/10.1038/nature12715CrossRefPubMedPubMedCentral

17.

Dinalankara, D. M., Miles, J. H., Nicole Takahashi, T., & Yao, G. (2017). Atypical pupillary light reflex in 2–6‐year‐old children with autism spectrum disorders. Autism Research, 10(5):829–838. https://doi.org/10.1002/aur.1745

18.

McNett M, Moran C, Janki C, Gianakis A (2017) Correlations between hourly pupillometer readings and intracranial pressure values. J Neurosci Nursing 49(4):229–234. https://doi.org/10.1097/JNN.0000000000000290CrossRef

19.

Bradley JC, Bentley KC, Mughal AI, Bodhireddy H, Brown SM (2011) Dark-adapted pupil diameter as a function of age measured with the NeurOptics pupillometer. J Refractive Surgery 27(3):202–207. https://doi.org/10.3928/1081597X-20100511-01CrossRef

20.

Kohnen T, Terzi E, Bühren J, Kohnen EM (2003) Comparison of a digital and a handheld infrared pupillometer for determining scotopic pupil diameter. J Cataract & Refractive Surgery 29(1):112–117CrossRef

21.

Scheffel M, Kuehne C, Kohnen T (2010) Comparison of monocular and binocular infrared pupillometers under mesopic lighting conditions. J Cataract & Refractive Surgery 36(4):625–630CrossRef

22.

Kerr RG, Bacon AM, Baker LL, Gehrke JS, Hahn KD, Lillegraven CL, Hackett-Renner C, Spilman SK (2016) Underestimation of pupil size by critical care and neurosurgical nurses. Amer J Critical Care 25(3):213–219. https://doi.org/10.4037/ajcc2016554CrossRef

23.

Marshall M, Deo R, Childs C, Ali A (2019) Feasibility and variability of automated pupillometry among stroke patients and healthy participants: potential implications for clinical practice. J Neurosci Nursing 51(2):84–88. https://doi.org/10.1097/JNN.0000000000000416CrossRef

24.

Winston M, Zhou A, Rand CM, Dunne EC, Warner JJ, Volpe LJ, Pigneri BA, Simon D, Bielawiec T, Gordon SC, Vitez SF, Charnay A, Joza S, Kelly K, Panicker C, Rizvydeen S, Niewijk G, Coleman C, Scher BJ, Reed, D.W.,…& (2019) Pupillometry measures of autonomic nervous system regulation with advancing age in a healthy pediatric cohort. Clinical Autonomic Res 1-9. https://doi.org/10.1007/s10286-019-00639-3

25.

de Vries L, Fouquaet I, Boets B, Naulaers G, Steyaert J (2020) Autism spectrum disorder and pupillometry: a systematic review and meta-analysis. Neurosci Biobehav Rev. https://doi.org/10.1016/j.neubiorev.2020.09.032CrossRefPubMed

26.

Kaufman AS, Kaufman NL (2004) Kaufman Brief Intelligence Test-Second Edition. Pearson Inc, Bloomington, MN

27.

Le Couteur A, Lord C, Rutter M (2003) Autism Diagnostic Interview-Revised. Manual. Western Psychological Services, Torrance, CA

28.

Constantino, J. (2012). Social Responsiveness Scale, Second Edition Manual. Torrance, CA: Western Psychological Services.

29.

NeurOptics, Inc. PLR-3000 research device. Irvine, CA.

30.

MedCalc (2021) MedCalc Statistical Software, version 20.010; Ostend, Belgium: MedCalc Software.

31.

Mathworks, Inc (2019) MATLAB and statistics toolbox, version 9.6.01174912, release 2019a. Natick, MA: The Mathworks Inc.

32.

StataCorp (2019) Stata Statistical Software: Release 16. College Station, TX: StataCorp LLC

33.

DeLong, E. R., DeLong, D. M., & Clarke-Pearson, D. L. (1988). Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics, 837–845.

34.

Efron B (1987) Better bootstrap confidence intervals. J Am Stat Assoc 82(397):171–185CrossRef

35.

Lasko TA, Bhagwat JG, Zou KH, Ohno-Machado L (2005) The use of receiver operating characteristic curves in biomedical informatics. J Biomed Inform 38(5):404–415CrossRef

36.

Nyström P, Gredebäck G, Bölte S, Falck-Ytter T (2015) Hypersensitive pupillary light reflex in infants at risk for autism. Molecular Autism 6(1):10CrossRef

37.

Kercher C, Azinfar L, Dinalankara DM, Takahashi TN, Miles JH, Yao G (2020) A longitudinal study of pupillary light reflex in 6-to 24-month children. Sci Rep 10(1):1–9. https://doi.org/10.1038/s41598-020-58254-6CrossRef

38.

Fish LA, Nyström P, Gliga T, Gui A, Begum Ali J, Mason L, ... BASIS/STAARS* team (2021) Development of the pupillary light reflex from 9 to 24 months: association with common autism spectrum disorder (ASD) genetic liability and 3‐year ASD diagnosis. Journal of Child Psychology and Psychiatry 62(11), 1308-1319

Titel: Sensitivity and specificity of pupillary light reflex measures for ASD using monocular pupillometry
verfasst von: Georgina T. F. Lynch
Stephen M. James
Teresa A. Cardon
Sterling M. McPherson
Publikationsdatum: 02.03.2022
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 7/2022
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-05976-2

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Introduction

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 7/2022

Overcoming therapeutic nihilism. Breaking bad news of amyotrophic lateral sclerosis—a patient-centred perspective in rare diseases

Terson syndrome in reverse: intraventricular haemorrhage following primary intraocular haemorrhage

Inattentional blindness to DWI lesions in spontaneous intracerebral hemorrhage

Increase in CGRP levels in a case of hemicrania continua normalizes after a successful response to galcanezumab

The association between stroke and COVID-19-related mortality: a systematic review and meta-analysis based on adjusted effect estimates