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Journal of Endocrinological Investigation

Erschienen in:

01.10.2016 | Original Article

Serum 25-hydroxyvitamin D status among Saudi children with and without a history of fracture

verfasst von: N. M. Al-Daghri, N. Aljohani, S. Rahman, S. Sabico, O. S. Al-Attas, M. S. Alokail, A. Al-Ajlan, G. P. Chrousos

Erschienen in: Journal of Endocrinological Investigation | Ausgabe 10/2016

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Abstract

Background

The significance of vitamin D deficiency in the incidence of bone fractures in children has been under investigated. Here, we aimed to associate serum 25-hydroxyvitamin D levels and fractures in Saudi children.

Materials and methods

This cross-sectional study was conducted in 1022 Saudi children without fracture history [476 boys (age 14.56 ± 1.81, BMI 22.38 ± 5.81) and 546 girls (age 13.57 ± 1.67, BMI 22.24 ± 4.94)] and 234 Saudi children with a history of fracture [148 boys (age 14.25 ± 1.39, BMI 22.66 ± 6.08) and 86 girls (age 13.76 ± 1.35, BMI 21.33 ± 1.35)]. Anthropometric and fasting serum biochemical data were collected. Serum 25-hydroxyvitamin D level was assessed using electrochemiluminescence.

Results

Mean circulating 25-hydroxyvitamin (25OH) D level in subjects with a history of fracture was significantly lower in both boys (p < 0.01) and girls (p < 0.01) than those without, however both groups had low mean 25(OH)D levels. Furthermore, age was positively associated with 25-hydroxyvitamin D in boys (p < 0.05) and negatively in girls (p < 0.05) with a history of fracture.

Conclusion

In conclusion, vitamin D levels were significantly lower in children with a history of bone fractures in both boys and girls than those without such a history; even in the absence of fracture history, vitamin D status correction is warranted in the general Saudi pediatric population.

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Titel: Serum 25-hydroxyvitamin D status among Saudi children with and without a history of fracture
verfasst von: N. M. Al-Daghri
N. Aljohani
S. Rahman
S. Sabico
O. S. Al-Attas
M. S. Alokail
A. Al-Ajlan
G. P. Chrousos
Publikationsdatum: 01.10.2016
Verlag: Springer International Publishing
Erschienen in: Journal of Endocrinological Investigation / Ausgabe 10/2016
Elektronische ISSN: 1720-8386
DOI: https://doi.org/10.1007/s40618-016-0496-7

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Abstract

Background

Materials and methods

Results

Conclusion

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