Background
Methods
Inclusion and exclusion criteria
Data collection
Severity assessment of AP
Diagnostic criteria for systemic inflammatory response syndrome (SIRS)
Statistical analysis
Results
Comparison of clinical characteristics
ALL | High HBDH | Normal HBDH | P value | |
---|---|---|---|---|
N = 260 | N = 84 | N = 176 | ||
Age (mean ± SD), years | 51.7 ± 16.1 | 52.4 ± 16.6 | 51.3 ± 16.0 | 0.617 |
Male sex, N (%) | 162 (62.3) | 48 (57.1) | 114 (64.8) | 0.235 |
Smoking, N (%) | 80 (30.8) | 26 (31.0) | 54(30.7) | 0.965 |
Drinking, N (%) | 57 (21.9) | 22 (26.2) | 35 (19.9) | 0.251 |
Underlying diseases, N (%) | ||||
Diabetes | 52 (20.0) | 19 (22.6) | 33 (18.8) | 0.466 |
Hypertriglyceridemia | 65 (25.0) | 21 (25.0) | 44 (25.0) | 1.000 |
hypertension | 93 (35.8) | 36 (42.9) | 57 (32.4) | 0.100 |
NAFLD | 108 (41.5) | 32 (38.1) | 76 (43.2) | 0.436 |
Etiology, N (%) | 0.241 | |||
Biliary | 63 (24.2) | 22 (26.2) | 41 (23.3) | |
Alcohol | 37 (14.2) | 11 (13.1) | 26 (14.8) | |
Hypertriglyceridemia | 105 (40.4) | 39 (46.4) | 66 (37.5) | |
Others | 55 (21.2) | 12 (14.3) | 43 (24.4) | |
Severity, N (%) | < 0.001*** | |||
MAP | 179 (68.8) | 40 (47.6) | 139 (79.0) | |
MSAP | 65 (25.0) | 32 (38.1) | 33 (18.8) | |
SAP | 16 (6.2) | 12 (14.3) | 4 (2.3) | |
OF, N (%) | 81 (31.2) | 44 (52.4) | 37 (21.0) | < 0.001*** |
SIRS, N (%) | 75 (28.8) | 39 (46.4) | 36 (20.5) | < 0.001*** |
Mortality, N (%) | 3 (1.2) | 2 (2.4) | 1 (0.6) | 0.201 |
Serum HBDH levels and severity of AP
ALL | High HBDH | Normal HBDH | P value | |
---|---|---|---|---|
N = 260 | N = 84 | N = 176 | ||
WBC, × 10*9/L | 12.4 ± 5.1 | 13.9 ± 5.6 | 11.7 ± 4.7 | 0.002** |
N% | 79.7 ± 13.5 | 83.0 ± 9.8 | 78.1 ± 14.8 | 0.007** |
LDH,U/L | 253.1 ± 131.1 | 335.9 ± 160.1 | 213.5 ± 91.7 | < 0.001*** |
DB, μmol/L | 6.3 ± 14.1 | 9.0 ± 19.8 | 5.0 ± 10.2 | 0.080* |
AST, U/L | 91.2 ± 145.9 | 130.6 ± 202.9 | 72.4 ± 104.3 | 0.015* |
ALT, U/L | 88.7 ± 133.7 | 121.2 ± 186.6 | 73.2 ± 95.8 | 0.028* |
GGT, U/L | 183.2 ± 273.9 | 269.5 ± 360.7 | 142.0 ± 209.9 | 0.003** |
BUN, mmol/L | 5.1 ± 2.2 | 5.5 ± 2.8 | 4.9 ± 1.9 | 0.046* |
CRP, mg/L | 33.7 ± 36.8 | 42.3 ± 45.1 | 29.6 ± 31.4 | 0.022* |
Ca2+, mmol/L | 2.3 ± 0.2 | 2.2 ± 0.2 | 2.3 ± 0.2 | < 0.001*** |
Cr, μmol/L | 63.5 ± 25.1 | 67.0 ± 33.2 | 61.8 ± 20.1 | 0.189 |
Glu, mmol/L | 8.8 ± 0.3 | 9.6 ± 0.6 | 8.4 ± 0.4 | 0.066 |
Serum HBDH levels and clinical scoring systems in AP
Correlation between serum HBDH levels and other clinical indicators
Index | R (with HBDH) | P value | Index | R (with HBDH) | P value |
---|---|---|---|---|---|
WBC | 0.273 | < 0.001*** | Glu | 0.171 | 0.006** |
N% | 0.162 | 0.009** | CRP | 0.182 | 0.003** |
LDH | 0.467 | < 0.001*** | DB | 0.052 | 0.399 |
AST | 0.152 | 0.014* | Ca2+ | 0.043 | 0.491 |
GGT | 0.150 | 0.015* | Cr | 0.107 | 0.084 |
BUN | 0.165 | 0.008** | HDL | 0.057 | 0.368 |
TG | 0.195 | 0.002** | LDL | − 0.062 | 0.325 |
CHO | 0.132 | 0.037* | ALT | 0.103 | 0.096 |