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Erschienen in:
01.05.2009 | Laboratory and Translational Research
Serum Matrilysin Levels Predict Outcome in Curatively Resected Colorectal Cancer Patients
Erschienen in: Annals of Surgical Oncology | Ausgabe 5/2009
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Background
Matrix metalloproteinase 7 (MMP-7) is involved in invasion, metastasis, growth, and angiogenesis. The aim of this study is to assess the prognostic role of serum MMP-7 in curatively resected colorectal cancer (CRC).
Materials and Methods
Patients undergoing resection for CRC (n = 175) were recruited from July 2003 to December 2004. MMP-7 was determined using a quantitative solid phase sandwich ELISA. Cox analysis was used to assess the role of MMP-7 in predicting overall survival (OS) and disease-free survival (DFS).
Results
The median length of follow-up was 45 months (range 1 to 59). Levels of MMP-7 are predictors of DFS (hazard ratio [HR] 1.119, 95% confidence interval [95% CI] 1.038–1.207) and of OS (HR 1.113, 95% CI 1.025–1.209). Patients with MMP-7 higher than the median (4.3 ng/ml) are more likely to relapse (29.5% vs 18.4%, P = .084); median time to progression in relapsed patients is 8 months if MMP-7 is ≥4.3 ng/ml and 18 months if MMP-7 is <4.3 ng/ml. Node-negative patients with low MMP-7 have a predicted probability of relapse-free survival at 4 years of 88% (95% CI 83–92%); if the MMP-7 is higher than the median value; this probability is 77% (95% CI 73–81%).
Conclusion
MMP-7 predicts recurrence in curatively resected CRC patients.