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Tumor Biology

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01.12.2015 | Research Article

Shikonin inhibits invasiveness of osteosarcoma through MMP13 suppression

verfasst von: Biyong Deng, Bing Qiu

Erschienen in: Tumor Biology | Ausgabe 12/2015

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Abstract

Osteosarcoma (OS) is the most common primary malignant bone tumor, notorious for its metastasis. We have recently shown that shikonin, an effective constituent extracted from Chinese medicinal herb, induces necroptosis in OS cells. Nevertheless, the effects of low-dose shikonin on the invasiveness of OS cells are unknown. Here, we showed that shikonin dose-dependently decreased OS cell invasiveness in both scratch wound healing assay and transwell cell migration assay. Moreover, the direct target of shikonin on cell invasiveness was found to be matrix metalloproteinase (MMP)-13. Further, the inhibitory effects of shikonin on cell invasiveness were completely abolished in MMP13-overexpressing OS cells. Together, these data suggest that shikonin may suppress OS invasiveness through MMP13 suppression. Thus, our data highlight a previous unappreciated role for shikonin in suppressing OS cell metastasis.

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Titel: Shikonin inhibits invasiveness of osteosarcoma through MMP13 suppression
verfasst von: Biyong Deng
Bing Qiu
Publikationsdatum: 01.12.2015
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 12/2015
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-015-3662-1

Springer Medizin

Shikonin inhibits invasiveness of osteosarcoma through MMP13 suppression

Abstract

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Abstract

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