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European Archives of Oto-Rhino-Laryngology

Erschienen in:

01.09.2013 | Head and Neck

Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma

verfasst von: Alexandre Bozec, Marius Ilie, Olivier Dassonville, Elodie Long, Gilles Poissonnet, José Santini, Emmanuel Chamorey, Marc Ettaiche, Damien Chauvière, Frédéric Peyrade, Christophe Hebert, Karen Benezery, Anne Sudaka, Juliette Haudebourg, Eric Selva, Paul Hofman

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 10/2013

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Abstract

The objective of this study was to evaluate the potential detection of circulating tumor cells (CTCs) using the CellSearch (CS) Assay™ in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) and then to identify the clinical factors predictive of the presence of CTCs. The presence and number of CTCs were determined using the CS system before treatment, and in 10 healthy individuals (control group). The CS system was able to successfully identify the presence of CTCs in 8 of 49 patients (16 %) before therapy. No CTC was found in the control group. CTCs were detected before therapy in 1 of 19 patients (5 %) with N0 tumor and in 7 of 30 patients (23 %) with N1-2c tumor (p = 0.12; Fisher’s exact test). CTCs were identified in a relatively low proportion of patients with locally advanced HNSCC.

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Titel: Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma
verfasst von: Alexandre Bozec
Marius Ilie
Olivier Dassonville
Elodie Long
Gilles Poissonnet
José Santini
Emmanuel Chamorey
Marc Ettaiche
Damien Chauvière
Frédéric Peyrade
Christophe Hebert
Karen Benezery
Anne Sudaka
Juliette Haudebourg
Eric Selva
Paul Hofman
Publikationsdatum: 01.09.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 10/2013
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-013-2399-y

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Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma

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