Background
Methods
HPV DNA testing
Study endpoints
Statistical analysis
Results
Vaccination coverage
Cohort* | Year of analysis | Age at time of sample collection (y) | Full vaccination status, N (%) | |
---|---|---|---|---|
No | Yes | |||
1 | 2009/10 | 24–27 | 619a (93.9%) | 40 (6.1%) |
3 | 2014/15 | 598b (81.6%) | 135 (18.4%) | |
2 | 2009/10 | 19–22 | 458c (76.3%) | 142 (23.7%) |
4 | 2014/15 | 191d (51.9%) | 177 (48.1%) |
Prevalence of HPV 6 and 11 infection
Cohorta | N | HPV 6 | Rate difference (95% CI) | HPV 11 | Rate difference (95% CI | OR | ||
---|---|---|---|---|---|---|---|---|
Negative | Positive | Negative | Positive | |||||
1 | 659 | 645 (97.9%) | 14 (2.1%) | −0.0212 (− 0.039, − 0.01) P < 0.0001 | 658 (99.9%) | 1 (0.1%) | −0.0001 (− 0.0083, 0.0075) P = 1.0000 | 0.000 (not defined; 0.274) P < 0.0001 |
3 | 714 | 714 (100%) | 0 (0%) | 713 (99.9%) | 1 (0.1%) | |||
2 | 600 | 588 (98.0%) | 12 (2.0%) | −0.02 (−0.0383, − 0.0063) P = 0.0056 | 596 (99.3%) | 4 (0.7%) | −0.0067 (− 0.0197, 0.0052) P = 0.2753 | 0.000 (not defined; 0.580) p = 0.0048 |
4 | 368 | 368 (100%) | 0 (0%) | 368 (100%) | 0 (0%) |
Prevalence of genital warts
Cohorta | N | Genital warts | Rate difference (95% CI) | OR | |
---|---|---|---|---|---|
No | Yes | ||||
1 | 659 | 628 (95.3%) | 31 (4.7%) | 0.0302 (0.0109, 0.052)P = 0.0018 | 2.8877 (1.426; 6.226) p = 0.0016 |
3 | 714 | 702(98.3%) | 12(1.7%) | ||
2 | 600 | 592(98.7%) | 8(1.3%) | 0.0106(−0.0042, 0.0255)P = 0.1598 | 4.9595 (0.660; 220.656) p = 0.1649 |
4 | 368 | 367(99.7%) | 1(0.3%) | ||
1 + 2 | 1259 | 1220(96.9%) | 39(3.1%) | 0.019(0.0068, 0.032) P = 0.0022 | 2.6287 (1.364; 5.395) p = 0.0018 |
3 + 4 | 1082 | 1069(98.8%) | 13(1.2%) |
Lifestyle factors
Cohort 1(1983/84) | Cohort 2(1988/89) | Cohort 3(1993/94) | |
---|---|---|---|
Number recruited | 659 | 599 | 368 |
Smoking history | |||
Current | |||
Yes | 244 (37%) | 221 (37%) | 100 (27%) |
No | 413 (63%) | 377 (63%) | 268 (73%) |
Former | |||
Yes | 163 (25%) | 74 (12%) | 22 (6%) |
No | 345 (52%) | 392 (65%) | 246 (67%) |
Age at sexual debut (mean ± SD) | 16.9 ± 2.45 | 16.1 ± 1.67 | 16,2 ± 1.73 |
Stable relationship | |||
Yes | 529 (80%) | 423 (71%) | 264 (72%) |
No | 123 (28%) | 169 (28%) | 94 (25%) |
Number of sexual partners | |||
0 | 8 (1%) | 30 (5%) | 7 (2%) |
1 | 125 (19%) | 126 (21%) | 95 (26%) |
2–5 | 335 (51%) | 336 (56%) | 186 (50%) |
> 5 | 162 (25%) | 91 (15%) | 44 (12%) |