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Current Osteoporosis Reports

01.04.2016 | Secondary Causes of Osteoporosis (SJ Warden, Section Editor)

Skeletal Implications of Chronic Obstructive Pulmonary Disease

verfasst von: Barbara M. Misof, Carolina A. Moreira, Klaus Klaushofer, Paul Roschger

Erschienen in: Current Osteoporosis Reports | Ausgabe 2/2016

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Abstract

Chronic obstructive pulmonary disease (COPD) is associated with numerous comorbidities, among which osteoporosis is of high significance. Low bone mass and the occurrence of fragility fractures is a common finding in patients with COPD. Typical risk factors related directly or indirectly to these skeletal complications include systemic inflammation, tobacco smoking, vitamin D deficiency, and treatment with oral or inhaled corticosteroids. In particular, treatment with glucocorticoids appears to be a strong contributor to bone changes in COPD, but does not fully account for all skeletal complications. Additional to the effects of COPD on bone mass, there is evidence for COPD-related changes in bone microstructure and material properties. This review summarizes the clinical outcomes of low bone mass and increased fracture risk, and reports on recent observations in bone tissue and material in COPD patients.
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Metadaten
Titel
Skeletal Implications of Chronic Obstructive Pulmonary Disease
verfasst von
Barbara M. Misof
Carolina A. Moreira
Klaus Klaushofer
Paul Roschger
Publikationsdatum
01.04.2016
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 2/2016
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-016-0301-8

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