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Erschienen in: hautnah dermatologie 4/2016

12.07.2016 | Systemische Sklerodermie | Zertifizierte Fortbildung

Befall innerer Organe prognoserelevant

Sklerodermie — mehr als eine Hauterkrankung

verfasst von: Dr. med. Dieter Schöffel

Erschienen in: hautnah dermatologie | Ausgabe 4/2016

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Zusammenfassung

Die Sklerodermie (systemische Sklerose) ist eine Erkrankung aus der Gruppe der Kollagenosen, bei der es neben vaskulären Veränderungen zu Entzündungen kommt, die schließlich zu einer Fibrosierung führen. Zusätzlich zur Beteiligung der Haut und der Gefäße wird die Prognose der Erkrankung durch die Beteiligung innerer Organe (Lunge, Herz, Niere und Gastrointestinaltrakt) bestimmt.
Literatur
1.
Zurück zum Zitat Hoffmann-Vold AM, Gunnarsson R, Garen T et al. Performance of the 2013 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Systemic Sclerosis (SSc) in large, well-defined cohorts of SSc and mixed connective tissue disease. J Rheumatol 2015; 42, 60–63CrossRefPubMed Hoffmann-Vold AM, Gunnarsson R, Garen T et al. Performance of the 2013 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Systemic Sclerosis (SSc) in large, well-defined cohorts of SSc and mixed connective tissue disease. J Rheumatol 2015; 42, 60–63CrossRefPubMed
2.
Zurück zum Zitat Hoffmann-Vold AM, Aaløkken TM, Lund MB et al. Arthritis Rheum 2015. Predictive value of HRCT and concurrent lung function tests in systemic sclerosis. Arthritis Rheumatol. 2015;67(8):2205–12CrossRefPubMed Hoffmann-Vold AM, Aaløkken TM, Lund MB et al. Arthritis Rheum 2015. Predictive value of HRCT and concurrent lung function tests in systemic sclerosis. Arthritis Rheumatol. 2015;67(8):2205–12CrossRefPubMed
3.
Zurück zum Zitat Avouac J, Fransen J, Walker UA et al. Preliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research Group. EUSTAR Group. Ann Rheum Dis. 2011;70(3):476–81.CrossRefPubMed Avouac J, Fransen J, Walker UA et al. Preliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research Group. EUSTAR Group. Ann Rheum Dis. 2011;70(3):476–81.CrossRefPubMed
4.
Zurück zum Zitat Lunardi C, Dolcino M, Peterlana D et al. Antibodies against human cytomegalovirus in the pathogenesis of systemic sclerosis: a gene array approach. PLoS Med. 2006;3(1):e2.CrossRefPubMed Lunardi C, Dolcino M, Peterlana D et al. Antibodies against human cytomegalovirus in the pathogenesis of systemic sclerosis: a gene array approach. PLoS Med. 2006;3(1):e2.CrossRefPubMed
5.
Zurück zum Zitat Garabrant DH1, Lacey JV Jr, Laing TJ et al. Scleroderma and solvent exposure among women. Am J Epidemiol. 2003;157(6):493–500.CrossRefPubMed Garabrant DH1, Lacey JV Jr, Laing TJ et al. Scleroderma and solvent exposure among women. Am J Epidemiol. 2003;157(6):493–500.CrossRefPubMed
6.
Zurück zum Zitat Matucci-Cerinic M, Kahaleh B, Wigley FM. Review: evidence that systemic sclerosis is a vascular disease. Arthritis Rheum 2013, 65, 1952–1963CrossRef Matucci-Cerinic M, Kahaleh B, Wigley FM. Review: evidence that systemic sclerosis is a vascular disease. Arthritis Rheum 2013, 65, 1952–1963CrossRef
7.
Zurück zum Zitat Moore OA, Goh N, Corte T et al. Extent of disease on high-resolution computed tomography lung is a predictor of decline and mortality in systemic sclerosis-related interstitial lung disease. Rheumatology (Oxford). 2013;52(1):155–60CrossRef Moore OA, Goh N, Corte T et al. Extent of disease on high-resolution computed tomography lung is a predictor of decline and mortality in systemic sclerosis-related interstitial lung disease. Rheumatology (Oxford). 2013;52(1):155–60CrossRef
8.
Zurück zum Zitat Tashkin DP, Volkmann ER, Tseng CH et al. Relationship between quantitative radiographic assessment of interstitial lung disease and clinical features of systemic sclerosis. Doi: 2014-206076 Tashkin DP, Volkmann ER, Tseng CH et al. Relationship between quantitative radiographic assessment of interstitial lung disease and clinical features of systemic sclerosis. Doi: 2014-206076
9.
Zurück zum Zitat Hoffmann-Vold AM, Aaløkken TM, Lund MB et al. Arthritis Rheum 2015. Predictive value of HRCT and concurrent lung function tests in systemic sclerosis. Arthritis Rheumatol. 2015;67(8):2205–12CrossRefPubMed Hoffmann-Vold AM, Aaløkken TM, Lund MB et al. Arthritis Rheum 2015. Predictive value of HRCT and concurrent lung function tests in systemic sclerosis. Arthritis Rheumatol. 2015;67(8):2205–12CrossRefPubMed
10.
Zurück zum Zitat Wells AU, Hansell DM, Rubens et al. Fibrosing alveolitis in systemic sclerosis: indices of lung function in relation to extent of disease on computed tomography. Arthritis Rheum. 1997 Jul;40(7):1229–36PubMed Wells AU, Hansell DM, Rubens et al. Fibrosing alveolitis in systemic sclerosis: indices of lung function in relation to extent of disease on computed tomography. Arthritis Rheum. 1997 Jul;40(7):1229–36PubMed
11.
Zurück zum Zitat Avouac J, Airò P, Meune C et al.. Prevalence of pulmonary hypertension in systemic sclerosis in European Caucasians and metaanalysis of 5 studies. J Rheumatol. 2010;37(11):2290–8.CrossRefPubMed Avouac J, Airò P, Meune C et al.. Prevalence of pulmonary hypertension in systemic sclerosis in European Caucasians and metaanalysis of 5 studies. J Rheumatol. 2010;37(11):2290–8.CrossRefPubMed
12.
Zurück zum Zitat Allanore Y, Meune C. N-terminal pro brain natriuretic peptide: the new cornerstone of cardiovascular assessment in systemic sclerosis. Clin Exp Rheumatol. 2009; (3 Suppl 54):59–63. Allanore Y, Meune C. N-terminal pro brain natriuretic peptide: the new cornerstone of cardiovascular assessment in systemic sclerosis. Clin Exp Rheumatol. 2009; (3 Suppl 54):59–63.
13.
Zurück zum Zitat Galie N, Hoeper MM, Humbert M et al. Guidelines for the diagnosis and treatment of pulmonary hypertension.. Eur Heart J 2009; 30; 2493–2537CrossRefPubMed Galie N, Hoeper MM, Humbert M et al. Guidelines for the diagnosis and treatment of pulmonary hypertension.. Eur Heart J 2009; 30; 2493–2537CrossRefPubMed
14.
Zurück zum Zitat Coghlan JG, Denton CP, Grünig E et al. Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study. Ann Rheum Dis. 2014;73(7):1340–9.CrossRefPubMed Coghlan JG, Denton CP, Grünig E et al. Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study. Ann Rheum Dis. 2014;73(7):1340–9.CrossRefPubMed
15.
Zurück zum Zitat Bulkley BH, Ridolfi RL, Salyer WR et al. Myocardial lesions of progressive systemic sclerosis. A cause of cardiac dysfunction. Circulation. 1976;53(3):483–490CrossRefPubMed Bulkley BH, Ridolfi RL, Salyer WR et al. Myocardial lesions of progressive systemic sclerosis. A cause of cardiac dysfunction. Circulation. 1976;53(3):483–490CrossRefPubMed
16.
Zurück zum Zitat Sjogren RW. Gastrointestinal motility disorders in scleroderma. Arthritis Rheum. 1994;37(9):1265–82.CrossRefPubMed Sjogren RW. Gastrointestinal motility disorders in scleroderma. Arthritis Rheum. 1994;37(9):1265–82.CrossRefPubMed
18.
Zurück zum Zitat Avouac J, Mogavero G, Guerini H et al. Predictive factors of hand radiographic lesions in systemic sclerosis: a prospective study. Ann Rheum Dis. 2011;70(4):630–3.CrossRefPubMed Avouac J, Mogavero G, Guerini H et al. Predictive factors of hand radiographic lesions in systemic sclerosis: a prospective study. Ann Rheum Dis. 2011;70(4):630–3.CrossRefPubMed
19.
Zurück zum Zitat Medsger TA Jr, Masi AT, Rodnan GP et al. Survival with systemic sclerosis (scleroderma). A life-table analysis of clinical and demographic factors in 309 patients. Ann Intern Med. 1971;75(3):369–76CrossRefPubMed Medsger TA Jr, Masi AT, Rodnan GP et al. Survival with systemic sclerosis (scleroderma). A life-table analysis of clinical and demographic factors in 309 patients. Ann Intern Med. 1971;75(3):369–76CrossRefPubMed
20.
Zurück zum Zitat Altman RD, Medsger TA Jr, Bloch DA, Michel BA. Predictors of survival in systemic sclerosis (scleroderma). Arthritis Rheum. 1991; 34(4):403–13CrossRefPubMed Altman RD, Medsger TA Jr, Bloch DA, Michel BA. Predictors of survival in systemic sclerosis (scleroderma). Arthritis Rheum. 1991; 34(4):403–13CrossRefPubMed
21.
Zurück zum Zitat van den Hoogen FH, Boerbooms AM, Swaak AJ, Rasker JJ, van Lier HJ, van de Putte LB. Comparison of methotrexate with placebo in the treatment of systemic sclerosis: a 24 week randomized double-blind trial, followed by a 24 week observational trial. Br J Rheumatol. 1996 Apr;35(4):364–72CrossRefPubMed van den Hoogen FH, Boerbooms AM, Swaak AJ, Rasker JJ, van Lier HJ, van de Putte LB. Comparison of methotrexate with placebo in the treatment of systemic sclerosis: a 24 week randomized double-blind trial, followed by a 24 week observational trial. Br J Rheumatol. 1996 Apr;35(4):364–72CrossRefPubMed
22.
Zurück zum Zitat White B1, Moore WC, Wigley FM, Xiao HQ, Wise RA. Cyclophosphamide is associated with pulmonary function and survival benefit in patients with scleroderma and alveolitis. Ann Intern Med. 2000 Jun 20;132(12):947–54.CrossRefPubMed White B1, Moore WC, Wigley FM, Xiao HQ, Wise RA. Cyclophosphamide is associated with pulmonary function and survival benefit in patients with scleroderma and alveolitis. Ann Intern Med. 2000 Jun 20;132(12):947–54.CrossRefPubMed
23.
Zurück zum Zitat Tashkin DP, Elashoff R, Clements PJ et al.. Cyclophosphamid versus placebo in scleroderma lung disease. N Engl J Med 2006; 354; 2655–66CrossRefPubMed Tashkin DP, Elashoff R, Clements PJ et al.. Cyclophosphamid versus placebo in scleroderma lung disease. N Engl J Med 2006; 354; 2655–66CrossRefPubMed
24.
Zurück zum Zitat Panopoulos ST, Bournia VK, Trakada G et al. Mycophenolate versus cyclophosphamide for progressive interstitial lung disease associated with systemic sclerosis: a 2-year case control study. Lung 2013, 191, 483–489CrossRefPubMed Panopoulos ST, Bournia VK, Trakada G et al. Mycophenolate versus cyclophosphamide for progressive interstitial lung disease associated with systemic sclerosis: a 2-year case control study. Lung 2013, 191, 483–489CrossRefPubMed
25.
Zurück zum Zitat Jordan KP, Jöud A, Bergknut C et al. International comparisons of the consultation prevalence of musculoskeletal conditions using population-based healthcare data from England and Sweden. Ann Rheum Dis. 2014 Jan;73(1):212–8CrossRefPubMed Jordan KP, Jöud A, Bergknut C et al. International comparisons of the consultation prevalence of musculoskeletal conditions using population-based healthcare data from England and Sweden. Ann Rheum Dis. 2014 Jan;73(1):212–8CrossRefPubMed
26.
Zurück zum Zitat Farge D, Marolleau JP, Zohar S et al.. Autologous bone marrow transplantation in the treatment of refractory systemic sclerosis: early results from a French multicentre phase I-II study. Br J Haematol. 2002;119(3):726–39CrossRefPubMed Farge D, Marolleau JP, Zohar S et al.. Autologous bone marrow transplantation in the treatment of refractory systemic sclerosis: early results from a French multicentre phase I-II study. Br J Haematol. 2002;119(3):726–39CrossRefPubMed
27.
Zurück zum Zitat Pulido T, Adzerikho I, Channick RN et al. SERAPHIN Investigators. Macicentan and morbidity and mortality in pulmonary arterial hypertension. N Engl j Med 2013,369,809–818)CrossRefPubMed Pulido T, Adzerikho I, Channick RN et al. SERAPHIN Investigators. Macicentan and morbidity and mortality in pulmonary arterial hypertension. N Engl j Med 2013,369,809–818)CrossRefPubMed
28.
Zurück zum Zitat Oudiz RJ, Brundage BH, Galiè N et al. for the PHIRST Study Group. Tadalafil for the treatment of pulmonary arterial hypertension: a double-blind 52-week uncontrolled extension study. J Am Coll Cardiol. 2012;60(8):768–74.CrossRefPubMed Oudiz RJ, Brundage BH, Galiè N et al. for the PHIRST Study Group. Tadalafil for the treatment of pulmonary arterial hypertension: a double-blind 52-week uncontrolled extension study. J Am Coll Cardiol. 2012;60(8):768–74.CrossRefPubMed
Metadaten
Titel
Befall innerer Organe prognoserelevant
Sklerodermie — mehr als eine Hauterkrankung
verfasst von
Dr. med. Dieter Schöffel
Publikationsdatum
12.07.2016
Verlag
Springer Medizin
Erschienen in
hautnah dermatologie / Ausgabe 4/2016
Print ISSN: 0938-0221
Elektronische ISSN: 2196-6451
DOI
https://doi.org/10.1007/s15012-016-2065-3

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