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09.10.2020 | Original Article - Vascular Neurosurgery - Aneurysm

Small intracranial aneurysms in the Barrow Ruptured Aneurysm Trial (BRAT)

verfasst von: Joshua S. Catapano, Candice L. Nguyen, Fabio A. Frisoli, Soumya Sagar, Jacob F. Baranoski, Tyler S. Cole, Mohamed A. Labib, Alexander C. Whiting, Andrew F. Ducruet, Felipe C. Albuquerque, Michael T. Lawton

Erschienen in: Acta Neurochirurgica | Ausgabe 1/2021

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Abstract

Background

Treatment of small ruptured aneurysms (SRAs) remains controversial, with literature reporting difficulty with endovascular versus microsurgical approaches. This paper analyzes outcomes after endovascular coiling and microsurgical clipping among patients with SRAs prospectively enrolled in the Barrow Ruptured Aneurysm Trial (BRAT).

Method

All BRAT patients were included in this study. Patient demographics, aneurysm size, aneurysm characteristics, procedure-related complications, and outcomes at discharge and at 1-year and 6-year follow-up were evaluated. A modified Rankin scale (mRS) score > 2 was considered a poor outcome.

Results

Of 73 patients with SRAs, 40 were initially randomly assigned to endovascular coiling and 33 to microsurgical clipping. The rate of treatment crossover was significantly different between coiling and clipping; 25 patients who were assigned to coiling crossed over to clipping, and no clipping patients crossed over to coiling (P < 0.001). Among SRA patients, 15 underwent coiling and 58 underwent clipping; groups did not differ significantly in demographic characteristics or aneurysm type (P ≥ 0.11). Mean aneurysm diameter was significantly greater in the endovascular group (3.0 ± 0.3 vs 2.6 ± 0.6; P = 0.02). The incidence of procedure-related complications was similar for endovascular and microsurgical treatments (odds ratio [95% confidence interval], 1.0 [0.1–10.0], P = 0.98). Both groups had comparable overall outcome (mRS score > 2) at discharge and 1-year and 6-year follow-up (P = 0.48 and 0.73, respectively).

Conclusions

Most SRA patients in the BRAT underwent surgical clipping, with a high rate of crossover from endovascular approaches. Endovascular treatment was equivalent to surgical clipping with regard to procedure-related complications and neurologic outcomes.

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Titel: Small intracranial aneurysms in the Barrow Ruptured Aneurysm Trial (BRAT)
verfasst von: Joshua S. Catapano
Candice L. Nguyen
Fabio A. Frisoli
Soumya Sagar
Jacob F. Baranoski
Tyler S. Cole
Mohamed A. Labib
Alexander C. Whiting
Andrew F. Ducruet
Felipe C. Albuquerque
Michael T. Lawton
Publikationsdatum: 09.10.2020
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 1/2021
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-020-04602-4

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Small intracranial aneurysms in the Barrow Ruptured Aneurysm Trial (BRAT)