Erschienen in:
Open Access
01.12.2012 | Poster presentation
Smoking induces expression of ligands of the immune receptor NKG2D
verfasst von:
Caroline Ospelt, Giovanni G Camici, Fabia Brentano, Peter Künzler, Christoph Kolling, Renate E Gay, Beat A Michel, Steffen Gay
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 1/2012
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Excerpt
While different studies confirmed an increased risk for smokers to develop rheumatoid arthritis (RA), the mechanisms behind this phenomenon are not known up to now. In all probability, smoking induces expression or post-translational modification of immune activating proteins which then initiate an autoimmune reaction in individuals with a susceptible genetic background. To identify these triggering molecules we screened joints of mice that were exposed to cigarette smoke for differences of gene expression and verified our results in synovial tissues of human smokers. …