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Erschienen in: European Journal of Trauma and Emergency Surgery 5/2021

25.05.2020 | Original Article

Soluble terminal complement activation fragment sC5b-9: a new serum biomarker for traumatic brain injury?

verfasst von: Joshua Parry, Jiho Hwang, Cedric F. Stahel, Corey Henderson, Jason Nadeau, Stephen Stacey, Kathryn Beauchamp, Ernest E. Moore, Philip F. Stahel

Erschienen in: European Journal of Trauma and Emergency Surgery | Ausgabe 5/2021

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Abstract

Purpose

Terminal complement pathway activation after traumatic brain injury (TBI) leads to formation of the membrane attack complex (MAC/C5b-9) which induces neuronal cell death and host-mediated secondary brain injury. Serum levels of soluble MAC (sC5b-9) have not been previously determined in patients with isolated TBI.

Methods

A prospective observational cohort study was performed during a 5-year time-period on adult patients with isolated TBI admitted to an academic level I trauma center in the United States. Controls consisted of patients with femur shaft fractures with or without TBI to mitigate the effect of systemic complement activation by peripheral trauma. Healthy volunteers served as internal controls. The sC5b-9 serum concentrations were measured on the day of admission by enzyme-linked immunosorbent assay (ELISA) and compared between the study cohorts. Univariate analysis was performed to determine independent predictive variables of major complications during hospital admission.

Results

Serum sC5b-9 levels were significantly elevated in patients with isolated TBI (n = 42), compared to patients with isolated femoral shaft fractures (n = 36) or combined TBI and femoral shaft fractures (n = 30; p < 0.05). There was no significant difference in serum sC5b-9 levels between the femur group and the combined injury group, compared to the healthy volunteers (n = 21). Univariate analysis revealed serum sC5b-9 levels as an independent predictor of major postinjury complications after isolated TBI (p < 0.01).

Conclusion

The soluble terminal complement complex sC5b-9 represents a potential novel serum biomarker specific for isolated head injuries, since peripheral trauma did not appear to affect the serum sC5b-9 levels.
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Metadaten
Titel
Soluble terminal complement activation fragment sC5b-9: a new serum biomarker for traumatic brain injury?
verfasst von
Joshua Parry
Jiho Hwang
Cedric F. Stahel
Corey Henderson
Jason Nadeau
Stephen Stacey
Kathryn Beauchamp
Ernest E. Moore
Philip F. Stahel
Publikationsdatum
25.05.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Trauma and Emergency Surgery / Ausgabe 5/2021
Print ISSN: 1863-9933
Elektronische ISSN: 1863-9941
DOI
https://doi.org/10.1007/s00068-020-01407-z

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