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International Urogynecology Journal

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01.07.2011 | Original Article

Sp1 collagen I A1 polymorphism in women with stress urinary incontinence

verfasst von: Dimos Sioutis, Emmanuel Economou, Irene Lambrinoudaki, Vasilios Tsamadias, Maria Creatsa, Angelos Liapis

Erschienen in: International Urogynecology Journal | Ausgabe 7/2011

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Abstract

Introduction and hypothesis

Stress urinary incontinence (SUI) is in part attributed to qualitative and quantitative changes in connective tissue of the urogenital tract. We examined the association of collagen type I a1 (COLIA 1) Sp1 polymorphism with the risk of SUI.

Methods

Forty-five postmenopausal women suffering from urodynamically verified SUI (study group) were compared to 45 healthy volunteers (control). DNA was extracted from peripheral blood. The genotyping concerning the type 1 a1 collagen gene Sp1 polymorphism was performed with polymerase chain reaction.

Results

The polymorphic T allele was overrepresented in the SUI patients (63.2% versus 36.8%, p = 0.016). Odds ratio for SUI in women harboring the T allele was 2.19 (95% CI 1.149–4.176) compared to women with the wild-type genotype.

Conclusions

The COLIA1 Sp1 polymorphism is associated with increased prevalence of stress urinary incontinence in postmenopausal women.

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Titel: Sp1 collagen I A1 polymorphism in women with stress urinary incontinence
verfasst von: Dimos Sioutis
Emmanuel Economou
Irene Lambrinoudaki
Vasilios Tsamadias
Maria Creatsa
Angelos Liapis
Publikationsdatum: 01.07.2011
Verlag: Springer-Verlag
Erschienen in: International Urogynecology Journal / Ausgabe 7/2011
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-011-1372-9

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Sp1 collagen I A1 polymorphism in women with stress urinary incontinence

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