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06.03.2019 | Original Communication

Speech treatment improves dysarthria in multisystemic ataxia: a rater-blinded, controlled pilot-study in ARSACS

verfasst von: Adam P. Vogel, Lisa H. Stoll, Andreas Oettinger, Natalie Rommel, Eva-Maria Kraus, Dagmar Timmann, Dion Scott, Christina Atay, Elsdon Storey, Ludger Schöls, Matthis Synofzik

Erschienen in: Journal of Neurology | Ausgabe 5/2019

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Abstract

We aimed to provide proof-of-principle evidence that intensive home-based speech treatment can improve dysarthria in complex multisystemic degenerative ataxias, exemplified by autosomal recessive spastic ataxia Charlevoix-Saguenay (ARSACS). Feasibility and piloting efficacy of speech training specifically tailored to cerebellar dysarthria was examined through a 4-week program in seven patients with rater-blinded assessment of intelligibility (primary outcome) and naturalness and acoustic measures of speech (secondary outcomes) performed 4 weeks before, immediately prior to, and directly after training (intraindividual control design). Speech intelligibility and naturalness improved post treatment. This provides piloting evidence that ataxia-tailored speech treatment might be effective in degenerative cerebellar disease.

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Titel: Speech treatment improves dysarthria in multisystemic ataxia: a rater-blinded, controlled pilot-study in ARSACS
verfasst von: Adam P. Vogel
Lisa H. Stoll
Andreas Oettinger
Natalie Rommel
Eva-Maria Kraus
Dagmar Timmann
Dion Scott
Christina Atay
Elsdon Storey
Ludger Schöls
Matthis Synofzik
Publikationsdatum: 06.03.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 5/2019
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-019-09258-4

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Speech treatment improves dysarthria in multisystemic ataxia: a rater-blinded, controlled pilot-study in ARSACS

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