Ausgabe 1/2015
Inhalt (89 Artikel)
IL-6 and Akt are involved in muscular pathogenesis in myasthenia gravis
Marie Maurer, Sylvain Bougoin, Tali Feferman, Mélinée Frenkian, Jacky Bismuth, Vincent Mouly, Geraldine Clairac, Socrates Tzartos, Elie Fadel, Bruno Eymard, Sara Fuchs, Miriam C Souroujon, Sonia Berrih-Aknin
Neuronal nucleus and cytoplasm volume deficit in children with autism and volume increase in adolescents and adults
Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Shuang Yong Ma, Humi Imaki, Jarek Wegiel, Janusz Frackowiak, Bozena Mazur Kolecka, Teresa Wierzba-Bobrowicz, Eric London, Thomas Wisniewski, Patrick R Hof, W Ted Brown
Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid
Chiara Nicolini, Younghee Ahn, Bernadeta Michalski, Jong M Rho, Margaret Fahnestock
Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma
Serena Pellegatta, Lorella Valletta, Cristina Corbetta, Monica Patanè, Ileana Zucca, Federico Riccardi Sirtori, Maria Grazia Bruzzone, Gianpaolo Fogliatto, Antonella Isacchi, Bianca Pollo, Gaetano Finocchiaro
Early detection of structural abnormalities and cytoplasmic accumulation of TDP-43 in tissue-engineered skins derived from ALS patients
Bastien Paré, Lydia Touzel-Deschênes, Rémy Lamontagne, Marie-Soleil Lamarre, François-Dominique Scott, Hélène T Khuong, Patrick A Dion, Jean-Pierre Bouchard, Peter Gould, Guy A Rouleau, Nicolas Dupré, François Berthod, François Gros-Louis
LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease
Michelle Rothaug, Stijn Stroobants, Michaela Schweizer, Judith Peters, Friederike Zunke, Mirka Allerding, Rudi D’Hooge, Paul Saftig, Judith Blanz
Phosphorylated α-synuclein in Parkinson’s disease: correlation depends on disease severity
Tessandra Stewart, Vesna Sossi, Jan O Aasly, Zbigniew K Wszolek, Ryan J Uitti, Kazuko Hasegawa, Teruo Yokoyama, Cyrus P Zabetian, James B Leverenz, Alexander Jon Stoessl, Yu Wang, Carmen Ginghina, Changqin Liu, Kevin C Cain, Peggy Auinger, Un Jung Kang, Poul Henning Jensen, Min Shi, Jing Zhang
Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy
Laura J Blair, Haley D Frauen, Bo Zhang, Bryce A Nordhues, Sara Bijan, Yen-Chi Lin, Frank Zamudio, Lidice D Hernandez, Jonathan J Sabbagh, Maj-Linda B Selenica, Chad A Dickey
Loss of angiotensin II receptor expression in dopamine neurons in Parkinson’s disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation
W Michael Zawada, Robert E Mrak, JoAnn Biedermann, Quinton D Palmer, Stephen M Gentleman, Orwa Aboud, W Sue T Griffin
Early neurone loss in Alzheimer’s disease: cortical or subcortical?
Thomas Arendt, Martina K Brückner, Markus Morawski, Carsten Jäger, Hermann-Josef Gertz
NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma
Maria-Magdalena Georgescu, Paul Yell, Bret C Mobley, Ping Shang, Theodora Georgescu, Shih-Hsiu J Wang, Peter Canoll, Kimmo J Hatanpaa, Charles L White III, Jack M Raisanen
Structural alterations of the intestinal epithelial barrier in Parkinson’s disease
Thomas Clairembault, Laurène Leclair-Visonneau, Emmanuel Coron, Arnaud Bourreille, Séverine Le Dily, Fabienne Vavasseur, Marie-Françoise Heymann, Michel Neunlist, Pascal Derkinderen
Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury
Ayse Ulusoy, Ruth E Musgrove, Raffaella Rusconi, Michael Klinkenberg, Michael Helwig, Anja Schneider, Donato A Di Monte
Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease
Amy M Pooler, Manuela Polydoro, Eduardo A Maury, Samantha B Nicholls, Snigdha M Reddy, Susanne Wegmann, Christopher William, Lubna Saqran, Ozge Cagsal-Getkin, Rose Pitstick, David R Beier, George A Carlson, Tara L Spires-Jones, Bradley T Hyman
TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies
Joery Goossens, Eugeen Vanmechelen, John Q Trojanowski, Virginia MY Lee, Christine Van Broeckhoven, Julie van der Zee, Sebastiaan Engelborghs
PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein
Carine Ciron, Lu Zheng, Wojciech Bobela, Graham W Knott, Teresa C Leone, Daniel P Kelly, Bernard L Schneider
Epileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities
Alexander A Sosunov, Robert A McGovern, Charles B Mikell, Xiaoping Wu, David G Coughlin, Peter B Crino, Howard L Weiner, Saadi Ghatan, James E Goldman, Guy M McKhann II
Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases
Joan Torrent, Alba Vilchez-Acosta, Diego Muñoz-Torrero, Marie Trovaslet, Florian Nachon, Arnaud Chatonnet, Katarina Grznarova, Isabelle Acquatella-Tran Van Ba, Ronan Le Goffic, Laetitia Herzog, Vincent Béringue, Human Rezaei
A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques
Fermin Moreno, Gil D Rabinovici, Anna Karydas, Zachary Miller, Sandy Chan Hsu, Andrea Legati, Jamie Fong, Daniel Schonhaut, Hermann Esselmann, Christa Watson, Melanie L Stephens, Joel Kramer, Jens Wiltfang, William W Seeley, Bruce L Miller, Giovanni Coppola, Lea Tenenholz Grinberg
IFNβ secreted by microglia mediates clearance of myelin debris in CNS autoimmunity
Magdalena Kocur, Reiner Schneider, Ann-Kathrin Pulm, Jens Bauer, Sonja Kropp, Michael Gliem, Jens Ingwersen, Norbert Goebels, Judith Alferink, Timour Prozorovski, Orhan Aktas, Stefanie Scheu
Ability of wild type mouse bioassay to detect bovine spongiform encephalopathy (BSE) in the presence of excess scrapie
Erica Corda, Leigh Thorne, Katy E Beck, Richard Lockey, Robert B Green, Christopher M Vickery, Thomas M Holder, Linda A Terry, Marion M Simmons, John Spiropoulos
Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma
Jonas Ecker, Ina Oehme, Ralph Mazitschek, Andrey Korshunov, Marcel Kool, Thomas Hielscher, Judit Kiss, Florian Selt, Carina Konrad, Marco Lodrini, Hedwig E Deubzer, Andreas von Deimling, Andreas E Kulozik, Stefan M Pfister, Olaf Witt, Till Milde
Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation
Jochen Martin Decker, Lars Krüger, Astrid Sydow, Shanting Zhao, Michael Frotscher, Eckhard Mandelkow, Eva-Maria Mandelkow
FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis
Yoshihiro Kino, Chika Washizu, Masaru Kurosawa, Mizuki Yamada, Haruko Miyazaki, Takumi Akagi, Tsutomu Hashikawa, Hiroshi Doi, Toru Takumi, Geoffrey G Hicks, Nobutaka Hattori, Tomomi Shimogori, Nobuyuki Nukina
Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau
Katja Hochgräfe, Astrid Sydow, Dorthe Matenia, Daniela Cadinu, Stefanie Könen, Olga Petrova, Marcus Pickhardt, Petra Goll, Fabio Morellini, Eckhard Mandelkow, Eva-Maria Mandelkow
microRNA network analysis identifies miR-29 cluster as key regulator of LAMA2 in ependymoma
Anbarasu Lourdusamy, Ruman Rahman, Stuart Smith, Richard Grundy
Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates
Citlalli Netzahualcoyotzi, Ricardo Tapia
Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica
Melina V. Jones, Hwa Huang, Peter A. Calabresi, Michael Levy
Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy
Keiko Nakamura, Fumiaki Mori, Tomoya Kon, Kunikazu Tanji, Yasuo Miki, Masahiko Tomiyama, Hidekachi Kurotaki, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Masahito Yamada, Koichi Wakabayashi
Identification of targets for rational pharmacological therapy in childhood craniopharyngioma
Jacob M. Gump, Andrew M. Donson, Diane K. Birks, Vladimir M. Amani, Karun K. Rao, Andrea M. Griesinger, B. K. Kleinschmidt-DeMasters, James M. Johnston, Richard C. E. Anderson, Amy Rosenfeld, Michael Handler, Lia Gore, Nicholas Foreman, Todd C. Hankinson
Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
Inge R Holtman, Divya D Raj, Jeremy A Miller, Wandert Schaafsma, Zhuoran Yin, Nieske Brouwer, Paul D Wes, Thomas Möller, Marie Orre, Willem Kamphuis, Elly M Hol, Erik W G M Boddeke, Bart J L Eggen
Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging
Adam D. Bachstetter, Linda J. Van Eldik, Frederick A. Schmitt, Janna H. Neltner, Eseosa T. Ighodaro, Scott J. Webster, Ela Patel, Erin L. Abner, Richard J, Kryscio, Peter T. Nelson
High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration
Jeanna M. Wheeler, Pamela J. McMillan, Michele Hawk, Michiyo Iba, Linda Robinson, George J. Xu, Beth A. Dombroski, Doori Jeong, Marc A. Dichter, Halvor Juul, Elaine Loomis, Murray Raskind, James B. Leverenz, John Q. Trojanowski, Virginia M.Y. Lee, Gerard D. Schellenberg, Brian C. Kraemer
DNA copy number analysis of Grade II–III and Grade IV gliomas reveals differences in molecular ontogeny including chromothripsis associated with IDH mutation status
Adam Cohen, Mariko Sato, Kenneth Aldape, Clinton C. Mason, Kristin Alfaro-Munoz, Lindsey Heathcock, Sarah T. South, Lisa M. Abegglen, Joshua D. Schiffman, Howard Colman
Incidence and extent of TDP-43 accumulation in aging human brain
Akiko Uchino, Masaki Takao, Hiroyuki Hatsuta, Hiroyuki Sumikura, Yuta Nakano, Akane Nogami, Yuko Saito, Tomio Arai, Kazutoshi Nishiyama, Shigeo Murayama
Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS
Jacqueline C Mitchell, Remy Constable, Eva So, Caroline Vance, Emma Scotter, Leanne Glover, Tibor Hortobagyi, Eveline S. Arnold, Shuo-Chien Ling, Melissa McAlonis, Sandrine Da Cruz, Magda Polymenidou, Lino Tessarolo, Don W Cleveland, Christopher E Shaw
Distinct pathological phenotypes of Creutzfeldt-Jakob disease in recipients of prion-contaminated growth hormone
Ignazio Cali, Cathleen J. Miller, Joseph E. Parisi, Michael D. Geschwind, Pierluigi Gambetti, Lawrence B. Schonberger
Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration
Jorge Gomez-Deza, Youn-bok Lee, Claire Troakes, Matthew Nolan, Safa Al-Sarraj, Jean-Marc Gallo, Christopher E. Shaw
Neuropathology of Beta-propeller protein associated neurodegeneration (BPAN): a new tauopathy
R. Paudel, A. Li, S. Wiethoff, R. Bandopadhyay, K. Bhatia, R. de Silva, H. Houlden, J. L. Holton
Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue
Laetitia Lemoine, Laure Saint-Aubert, Amelia Marutle, Gunnar Antoni, Jonas P Eriksson, Bernardino Ghetti, Nobuyuki Okamura, Inger Nennesmo, Per-Göran Gillberg, Agneta Nordberg
Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice
Karthikeyan Balakrishnan, Ajeet Rijal Upadhaya, Julia Steinmetz, Julia Reichwald, Dorothee Abramowski, Marcus Fändrich, Sathish Kumar, Haruyasu Yamaguchi, Jochen Walter, Matthias Staufenbiel, Dietmar Rudolf Thal
Common neuropathological features underlie distinct clinical presentations in three siblings with hereditary diffuse leukoencephalopathy with spheroids caused by CSF1R p.Arg782His
John L. Robinson, EunRan Suh, Elisabeth M. Wood, Edward B. Lee, H. Branch Coslett, Kevin Raible, Virginia M.-Y. Lee, John Q. Trojanowski, Vivianna M. Van Deerlin
Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia
Jennifer L. Ziskin, Michael D. Greicius, Wan Zhu, Anna N. Okumu, Christopher M. Adams, Edward D. Plowey
Complete loss of the DNAJB6 G/F domain and novel missense mutations cause distal-onset DNAJB6 myopathy
Alessandra Ruggieri, Francesco Brancati, Simona Zanotti, Lorenzo Maggi, Maria Barbara Pasanisi, Simona Saredi, Chiara Terracciano, Carlo Antozzi, Maria Rosaria D′Apice, Federica Sangiuolo, Giuseppe Novelli, Christian R. Marshall, Stephen W. Scherer, Lucia Morandi, Luca Federici, Roberto Massa, Marina Mora, Berge A. Minassian
Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis
Gijs Kooij, Rens Braster, Jasper J. Koning, Lisa C. Laan, Sandra J. van Vliet, Tamara Los, Anne Marieke Eveleens, Susanne M. A. van der Pol, Elisabeth Förster-Waldl, Kaan Boztug, Alexandre Belot, Katka Szilagyi, Timo K. van den Berg, Jaap D. van Buul, Marjolein van Egmond, Helga E. de Vries, Richard D. Cummings, Christine D. Dijkstra, Irma van Die
Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression
Mathieu Bourdenx, Sandra Dovero, Michel Engeln, Simone Bido, Matthieu F. Bastide, Nathalie Dutheil, Isabel Vollenweider, Laetitia Baud, Camille Piron, Virginie Grouthier, Thomas Boraud, Grégory Porras, Qin Li, Veerle Baekelandt, Dieter Scheller, Anne Michel, Pierre-Olivier Fernagut, François Georges, Grégoire Courtine, Erwan Bezard, Benjamin Dehay
Spread of pathology in amyotrophic lateral sclerosis: assessment of phosphorylated TDP-43 along axonal pathways
Manaal Fatima, Rachel Tan, Glenda M. Halliday, Jillian J. Kril
Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase
Anna R. Malik, Ewa Liszewska, Agnieszka Skalecka, Malgorzata Urbanska, Anand M. Iyer, Lukasz J. Swiech, Malgorzata Perycz, Kamil Parobczak, Patrycja Pietruszka, Malgorzata M. Zarebska, Matylda Macias, Katarzyna Kotulska, Julita Borkowska, Wieslawa Grajkowska, Magdalena E. Tyburczy, Sergiusz Jozwiak, David J. Kwiatkowski, Eleonora Aronica, Jacek Jaworski
No neuropathological evidence for a direct topographical relation between microbleeds and cerebral amyloid angiopathy
Enikö Kövari, Andreas Charidimou, François R. Herrmann, Panteleimon Giannakopoulos, Constantin Bouras, Gabriel Gold
Histological criteria for atypical pituitary adenomas – data from the German pituitary adenoma registry suggests modifications
Christian P. Miermeister, Stephan Petersenn, Michael Buchfelder, Rudolf Fahlbusch, Dieter K. Lüdecke, Annett Hölsken, Markus Bergmann, Hans Ulrich Knappe, Volkmar H. Hans, Jörg Flitsch, Wolfgang Saeger, Rolf Buslei
Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons
Tomohiro Umeda, Elisa M. Ramser, Minato Yamashita, Koichi Nakajima, Hiroshi Mori, Michael A. Silverman, Takami Tomiyama
Molecular pathomechanisms and cell-type-specific disease phenotypes of MELAS caused by mutant mitochondrial tRNATrp
Hideyuki Hatakeyama, Ayako Katayama, Hirofumi Komaki, Ichizo Nishino, Yu-ichi Goto
Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse
Christopher M. Henstridge, Rosemary J. Jackson, JeeSoo M. Kim, Abigail G. Herrmann, Ann K. Wright, Sarah E. Harris, Mark E. Bastin, John M. Starr, Joanna Wardlaw, Thomas H. Gillingwater, Colin Smith, Chris-Anne McKenzie, Simon R. Cox, Ian J. Deary, Tara L. Spires-Jones
Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice
Matthew D. Howell, Lauren A. Bailey, Michael A. Cozart, Brenda M. Gannon, Paul E. Gottschall
Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn 2b/- mouse model of spinal muscular atrophy
Lyndsay M. Murray, Ariane Beauvais, Sabrina Gibeault, Natalie L. Courtney, Rashmi Kothary
Adoptive transfer of immune cells from glaucomatous mice provokes retinal ganglion cell loss in recipients
Oliver W. Gramlich, Qiong J. Ding, Wei Zhu, Amy Cook, Michael G. Anderson, Markus H. Kuehn
Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons
Hiroyuki Sumikura, Masaki Takao, Hiroyuki Hatsuta, Shinji Ito, Yuta Nakano, Akiko Uchino, Akane Nogami, Yuko Saito, Hideki Mochizuki, Shigeo Murayama
Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain
Yoann Sottejeau, Alexis Bretteville, François-Xavier Cantrelle, Nicolas Malmanche, Florie Demiaute, Tiago Mendes, Charlotte Delay, Harmony Alves Dos Alves, Amandine Flaig, Peter Davies, Pierre Dourlen, Bart Dermaut, Jocelyn Laporte, Philippe Amouyel, Guy Lippens, Julien Chapuis, Isabelle Landrieu, Jean-Charles Lambert
C9ORF72 expression and cellular localization over mouse development
Rachel A K Atkinson, Carmen M. Fernandez-Martos, Julie D. Atkin, James C. Vickers, Anna E. King
Cortical tau load is associated with white matter hyperintensities
Kirsty E. McAleese, Michael Firbank, Madhurima Dey, Sean J. Colloby, Lauren Walker, Mary Johnson, Joshua R. Beverley, John Paul Taylor, Alan J. Thomas, John T. O’Brien, Johannes Attems
Heterogeneity of aquaporin-4 localization and expression after focal cerebral ischemia underlies differences in white versus grey matter swelling
Jesse A. Stokum, Rupal I. Mehta, Svetlana Ivanova, Edward Yu, Volodymyr Gerzanich, J. Marc Simard
ALS-FUS pathology revisited: singleton FUS mutations and an unusual case with both a FUS and TARDBP mutation
Andrew King, Claire Troakes, Bradley Smith, Matthew Nolan, Olimpia Curran, Caroline Vance, Christopher E. Shaw, Safa Al-Sarraj
Significant neuronal soma volume deficit in the limbic system in subjects with 15q11.2-q13 duplications
Jerzy Wegiel, Michael Flory, N. Carolyn Schanen, Edwin H. Cook, Krzysztof Nowicki, Izabela Kuchna, Humi Imaki, Shuang Yong Ma, Jarek Wegiel, Eric London, Manuel F. Casanova, Thomas Wisniewski, W. Ted Brown
Gene co-expression analysis unravels a link between C9orf72 and RNA metabolism in myeloid cells
Serge Nataf, Laurent Pays
Lack of robust satellite cell activation and muscle regeneration during the progression of Pompe disease
Gerben J. Schaaf, Tom JM van Gestel, Esther Brusse, Robert M. Verdijk, Irenaeus FM de Coo, Pieter A. van Doorn, Ans T. van der Ploeg, WWM Pim Pijnappel
The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells
Asuka Kokawa, Seiko Ishihara, Hitomi Fujiwara, Mika Nobuhara, Minori Iwata, Yasuo Ihara, Satoru Funamoto
Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic plasticity
Aleksandar R. Zivkovic, Oliver Sedlaczek, Rebecca von Haken, Karsten Schmidt, Thorsten Brenner, Markus A. Weigand, Hilmar Bading, C. Peter Bengtson, Stefan Hofer
Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains
Jonathan Janssens, Stéphanie Philtjens, Gernot Kleinberger, Sara Van Mossevelde, Julie van der Zee, Rita Cacace, Sebastiaan Engelborghs, Anne Sieben, Julia Banzhaf-Strathmann, Lubina Dillen, Céline Merlin, Ivy Cuijt, Caroline Robberecht, Bettina Schmid, Patrick Santens, Adrian Ivanoiu, Mathieu Vandenbulcke, Rik Vandenberghe, Patrick Cras, Peter P. De Deyn, Jean-Jacques Martin, Stuart Maudsley, Christian Haass, Marc Cruts, Christine Van Broeckhoven
Two alternative pathways for generating transmissible prion disease de novo
Natallia Makarava, Regina Savtchenko, Ilia V. Baskakov
Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models
Fan Liao, Tony J. Zhang, Hong Jiang, Katheryn B. Lefton, Grace O. Robinson, Robert Vassar, Patrick M. Sullivan, David M. Holtzman
Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells
Claudia Späni, Tobias Suter, Rebecca Derungs, Maria Teresa Ferretti, Tobias Welt, Fabian Wirth, Christoph Gericke, Roger M. Nitsch, Luka Kulic
Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits
Guilian Xu, Yong Ran, Susan E. Fromholt, Chunhua Fu, Anthony T. Yachnis, Todd E. Golde, David R. Borchelt
Clinically early-stage CSPα mutation carrier exhibits remarkable terminal stage neuronal pathology with minimal evidence of synaptic loss
Bruno A. Benitez, Nigel J. Cairns, Robert E. Schmidt, John C. Morris, Joanne B. Norton, Carlos Cruchaga, Mark S. Sands
Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis
Franziska Denk, Leanne M. Ramer, Erin L. K. S. Erskine, Mohammed A. Nassar, Yury Bogdanov, Massimo Signore, John N. Wood, Stephen B. McMahon, Matt S. Ramer
Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein
Maria E. Bernis, Julius T. Babila, Sara Breid, Katharina Annick Wüsten, Ullrich Wüllner, Gültekin Tamgüney
Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson’s disease
Paula Garcia-Esparcia, Karina Hernández-Ortega, Anusha Koneti, Laura Gil, Raul Delgado-Morales, Ester Castaño, Margarita Carmona, Isidre Ferrer
Differential expression of galanin in the cholinergic basal forebrain of patients with Lewy body disorders
Athanasios Alexandris, Alan King Lun Liu, Raymond Chuen-Chung Chang, Ronald K. B. Pearce, Steve M. Gentleman
The domestic cat as a natural animal model of Alzheimer’s disease
James K. Chambers, Takahiko Tokuda, Kazuyuki Uchida, Ryotaro Ishii, Harutsugu Tatebe, Erika Takahashi, Takami Tomiyama, Yumi Une, Hiroyuki Nakayama
Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions
Philip G. Nijland, Remco J. Molenaar, Susanne M. A. van der Pol, Paul van der Valk, Cornelis J. F. van Noorden, Helga E. de Vries, Jack van Horssen
Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis ?
Romana Höftberger, Marianne Leisser, Jan Bauer, Hans Lassmann
The defining pathology of the new clinical and histopathologic entity ACTA2-related cerebrovascular disease
Maria-Magdalena Georgescu, Marco da Cunha Pinho, Timothy E. Richardson, Jose Torrealba, L. Maximilian Buja, Dianna M. Milewicz, Jack M. Raisanen, Dennis K. Burns
Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody
Kazuhiro Kurosawa, Tatsuro Misu, Yoshiki Takai, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Yoichiro Abe, Hiroko Iwanari, Ryo Ogawa, Ichiro Nakashima, Kazuo Fujihara, Takao Hamakubo, Masato Yasui, Masashi Aoki
Erratum to: Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse
Christopher M. Henstridge, Rosemary J. Jackson, JeeSoo M. Kim, Abigail G. Herrmann, Ann K. Wright, Sarah E. Harris, Mark E. Bastin, John M. Starr, Joanna Wardlaw, Thomas H. Gillingwater, Colin Smith, Chris-Anne McKenzie, Simon R. Cox, Ian J. Deary, Tara L. Spires-Jones
Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson’s disease
Anna Tamburrino, Madeline J. Churchill, Oi W. Wan, Yolanda Colino-Sanguino, Rossana Ippolito, Sofie Bergstrand, Daniel A. Wolf, Niculin J. Herz, Michelle D. Sconce, Anders Björklund, Charles K. Meshul, Mickael Decressac
Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion
Melanie Pages, Ludovic Lacroix, Arnault Tauziede-Espariat, David Castel, Estelle Daudigeos-Dubus, Vita Ridola, Sophie Gilles, Frederic Fina, Felipe Andreiuolo, Marc Polivka, Emmanuele Lechapt-Zalcman, Stephanie Puget, Nathalie Boddaert, Xiao-qiong Liu, Julia A. Bridge, Jacques Grill, Fabrice Chretien, Pascale Varlet
Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways
Tania A. Jones, Jennie N. Jeyapalan, Tim Forshew, Ruth G. Tatevossian, Andrew R. J. Lawson, Sheena N. Patel, Gabriel T. Doctor, Muhammad A. Mumin, Simon R. Picker, Kim P. Phipps, Antony Michalski, Thomas S. Jacques, Denise Sheer
Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter
Laura A. N. Peferoen, Wouter H. Gerritsen, Marjolein Breur, Kimberley M. D. Ummenthum, Regina M. B. Peferoen-Baert, Paul van der Valk, Johannes M. van Noort, Sandra Amor
PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients
Kaspar Draaisma, Maarten M. J. Wijnenga, Bas Weenink, Ya Gao, Marcel Smid, P. Robe, Martin J. van den Bent, Pim J. French
The NOTCH3 score: a pre-clinical CADASIL biomarker in a novel human genomic NOTCH3 transgenic mouse model with early progressive vascular NOTCH3 accumulation
Julie W. Rutten, Roselin R. Klever, Ingrid M. Hegeman, Dana S. Poole, Hans G. Dauwerse, Ludo A. M. Broos, Cor Breukel, Annemieke M. Aartsma-Rus, J. Sjef Verbeek, Louise van der Weerd, Sjoerd G. van Duinen, Arn M. J. M. van den Maagdenberg, Saskia A. J. Lesnik Oberstein