Ausgabe 1/2016
Inhalt (131 Artikel)
Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics
Lindsey M. Hoffman, Mariko DeWire, Scott Ryall, Pawel Buczkowicz, James Leach, Lili Miles, Arun Ramani, Michael Brudno, Shiva Senthil Kumar, Rachid Drissi, Phillip Dexheimer, Ralph Salloum, Lionel Chow, Trent Hummel, Charles Stevenson, Q. Richard Lu, Blaise Jones, David Witte, Bruce Aronow, Cynthia E. Hawkins, Maryam Fouladi
Erratum: C9ORF72 expression and cellular localization over mouse development
Rachel A. K. Atkinson, Carmen M. Fernandez-Martos, Julie D. Atkin, James C. Vickers, Anna E. King
Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS
Daniel Cacabelos, Omar Ramírez-Núñez, Ana Belén Granado-Serrano, Pascual Torres, Victòria Ayala, Victoria Moiseeva, Mònica Povedano, Isidre Ferrer, Reinald Pamplona, Manuel Portero-Otin, Jordi Boada
Farewell to GBM-O: Genomic and transcriptomic profiling of glioblastoma with oligodendroglioma component reveals distinct molecular subgroups
Benjamin H. Hinrichs, Scott Newman, Christina L. Appin, William Dunn, Lee Cooper, Rini Pauly, Jeanne Kowalski, Michael R. Rossi, Daniel J. Brat
SF3B1 and EIF1AX mutations occur in primary leptomeningeal melanocytic neoplasms; yet another similarity to uveal melanomas
Heidi V. N. Küsters-Vandevelde, David Creytens, Adriana C. H. van Engen-van Grunsven, Marcel Jeunink, Veronique Winnepenninckx, Patricia J. T. A. Groenen, Benno Küsters, Pieter Wesseling, Willeke A. M. Blokx, Clemens F. M. Prinsen
Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase
Eiichi Tokuda, Thomas Brännström, Peter M. Andersen, Stefan L. Marklund
Erratum: Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons
T Umeda, EM Ramser, M Yamashita, K Nakajima, H Mori, MA Silverman, T Tomiyama
New insights into the protein aggregation pathology in myotilinopathy by combined proteomic and immunolocalization analyses
A. Maerkens, M. Olivé, A. Schreiner, S. Feldkirchner, J. Schessl, J. Uszkoreit, K. Barkovits, A. K. Güttsches, V. Theis, M. Eisenacher, M. Tegenthoff, L. G. Goldfarb, R. Schröder, B. Schoser, P. F. M. van der Ven, D. O. Fürst, M. Vorgerd, K. Marcus, R. A. Kley
Diagnostically important muscle pathology in DNAJB6 mutated LGMD1D
Satu Sandell, Sanna Huovinen, Johanna Palmio, Olayinka Raheem, Mikaela Lindfors, Fang Zhao, Hannu Haapasalo, Bjarne Udd
Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions
Jérôme Chapuis, Mohammed Moudjou, Fabienne Reine, Laetitia Herzog, Emilie Jaumain, Céline Chapuis, Isabelle Quadrio, Jacques Boulliat, Armand Perret-Liaudet, Michel Dron, Hubert Laude, Human Rezaei, Vincent Béringue
Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study
Stephen B. Wharton, Thais Minett, David Drew, Gillian Forster, Fiona Matthews, Carol Brayne, Paul G. Ince
Animal modeling an oligodendrogliopathy – multiple system atrophy
Jonathan M. Bleasel, Glenda M. Halliday, Woojin Scott Kim
Erratum: Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics
Lindsey M. Hoffman, Mariko DeWire, Scott Ryall, Pawel Buczkowicz, James Leach, Lili Miles, Arun K. Ramani, Michael Brudno, Shiva Senthil Kumar, Rachid Drissi, Phillip Dexheimer, Ralph Salloum, Lionel Chow, Trent Hummel, Charles Stevenson, Q. Richard Lu, Blaise Jones, David Witte, Bruce Aronow, Cynthia E. Hawkins, Maryam Fouladi
CSF complement 3 and factor H are staging biomarkers in Alzheimer’s disease
William T. Hu, Kelly D. Watts, Prashant Tailor, Trung P. Nguyen, Jennifer C. Howell, Raven C. Lee, Nicholas T. Seyfried, Marla Gearing, Chadwick M. Hales, Allan I. Levey, James J. Lah, Eva K. Lee
Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons
Jurate Lasiene, Okiru Komine, Noriko Fujimori-Tonou, Berit Powers, Fumito Endo, Seiji Watanabe, Jin Shijie, John Ravits, Philip Horner, Hidemi Misawa, Koji Yamanaka
Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer’s APP/PSEN1 mice by gene targeting of diabetes/Alzheimer’s-related Sorcs1
Elysse M. Knight, Henry H. Ruiz, Soong Ho Kim, Jessica C. Harte, Wilson Hsieh, Charles Glabe, William L. Klein, Alan D. Attie, Christoph Buettner, Michelle E. Ehrlich, Sam Gandy
Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD
Astrid Sydow, Katja Hochgräfe, Stefanie Könen, Daniela Cadinu, Dorthe Matenia, Olga Petrova, Maria Joseph, Frank Johannes Dennissen, Eva-Maria Mandelkow
Retention of hexanucleotide repeat-containing intron in C9orf72 mRNA: implications for the pathogenesis of ALS/FTD
Michael Niblock, Bradley N. Smith, Youn-Bok Lee, Valentina Sardone, Simon Topp, Claire Troakes, Safa Al-Sarraj, Claire S. Leblond, Patrick A. Dion, Guy A. Rouleau, Christopher E. Shaw, Jean-Marc Gallo
A general homeostatic principle following lesion induced dendritic remodeling
Steffen Platschek, Hermann Cuntz, Mario Vuksic, Thomas Deller, Peter Jedlicka
Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles
Annett Hölsken, Martin Sill, Jessica Merkle, Leonille Schweizer, Michael Buchfelder, Jörg Flitsch, Rudolf Fahlbusch, Markus Metzler, Marcel Kool, Stefan M. Pfister, Andreas von Deimling, David Capper, David T. W. Jones, Rolf Buslei
Erratum: Histological criteria for atypical pituitary adenomas – data from the German pituitary adenoma registry suggests modifications
Christian P. Miermeister, Stephan Petersenn, Michael Buchfelder, Rudolf Fahlbusch, Dieter K. Lüdecke, Annett Hölsken, Markus Bergmann, Ulrich Johannes Knappe, Volkmar H. Hans, Jörg Flitsch, Wolfgang Saeger, Rolf Buslei
Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy
Antonio Piras, Ludovic Collin, Fiona Grüninger, Caroline Graff, Annica Rönnbäck
C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy
Rhona McGonigal, Madeleine E. Cunningham, Denggao Yao, Jennifer A. Barrie, Sethu Sankaranarayanan, Simon N. Fewou, Koichi Furukawa, Ted A. Yednock, Hugh J. Willison
Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer’s disease and transgenic mouse models
Jochim Reinert, Bernhard C. Richard, Hans W. Klafki, Beate Friedrich, Thomas A. Bayer, Jens Wiltfang, Gabor G. Kovacs, Martin Ingelsson, Lars Lannfelt, Anders Paetau, Jonas Bergquist, Oliver Wirths
Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes
Luisa Möhle, Nicole Israel, Kristin Paarmann, Markus Krohn, Sabine Pietkiewicz, Andreas Müller, Inna N. Lavrik, Jeffrey S. Buguliskis, Björn H. Schott, Dirk Schlüter, Eckart D. Gundelfinger, Dirk Montag, Ulrike Seifert, Jens Pahnke, Ildiko Rita Dunay
Pneumococcal meningitis: Clinical-pathological correlations (meningene-path)
Joo-Yeon Engelen-Lee, Matthijs C. Brouwer, Eleonora Aronica, Diederik van de Beek
High expression of α-synuclein in damaged mitochondria with PLA2G6 dysfunction
Hisae Sumi-Akamaru, Goichi Beck, Koei Shinzawa, Shinsuke Kato, Yuichi Riku, Mari Yoshida, Harutoshi Fujimura, Yoshihide Tsujimoto, Saburo Sakoda, Hideki Mochizuki
Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy
Laurent M. Willems, Nadine Zahn, Nerea Ferreirós, Klaus Scholich, Nicola Maggio, Thomas Deller, Andreas Vlachos
Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse
Sophia Schedin-Weiss, Ina Caesar, Bengt Winblad, Hans Blom, Lars O. Tjernberg
X-linked intellectual disability gene CASK regulates postnatal brain growth in a non-cell autonomous manner
Sarika Srivastava, Ryan McMillan, Jeffery Willis, Helen Clark, Vrushali Chavan, Chen Liang, Haiyan Zhang, Matthew Hulver, Konark Mukherjee
Characteristics of gliomas in patients with somatic IDH mosaicism
Charlotte Bonnet, Laure Thomas, Dimitri Psimaras, Franck Bielle, Elodie Vauléon, Hugues Loiseau, Stéphanie Cartalat-Carel, David Meyronet, Caroline Dehais, Jérôme Honnorat, Marc Sanson, François Ducray
A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions
Siân Baker, Jürgen Götz
Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy
Roya Behrouzi, Xiawei Liu, Dongyue Wu, Andrew C. Robinson, Sayuri Tanaguchi-Watanabe, Sara Rollinson, Jing Shi, Jinzhou Tian, Hisham H. M. Hamdalla, John Ealing, Anna Richardson, Matthew Jones, Stuart Pickering-Brown, Yvonne S. Davidson, Michael J. Strong, Masato Hasegawa, Julie S. Snowden, David M. A. Mann
Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain
Ksenia Kurbatskaya, Emma C. Phillips, Cara L. Croft, Giacomo Dentoni, Martina M. Hughes, Matthew A. Wade, Safa Al-Sarraj, Claire Troakes, Michael J. O’Neill, Beatriz G. Perez-Nievas, Diane P. Hanger, Wendy Noble
Evaluation of alpha-synuclein immunohistochemical methods for the detection of Lewy-type synucleinopathy in gastrointestinal biopsies
Anne-Gaëlle Corbillé, Franck Letournel, Jeffrey H. Kordower, John Lee, Elisheva Shanes, Michel Neunlist, David G. Munoz, Pascal Derkinderen, Thomas G. Beach
Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration
Ito Kawakami, Zen Kobayashi, Tetsuaki Arai, Osamu Yokota, Takashi Nonaka, Naoya Aoki, Kazuhiro Niizato, Kenichi Oshima, Shinji Higashi, Omi Katsuse, Masato Hosokawa, Masato Hasegawa, Haruhiko Akiyama
C9orf72 is differentially expressed in the central nervous system and myeloid cells and consistently reduced in C9orf72, MAPT and GRN mutation carriers
Patrizia Rizzu, Cornelis Blauwendraat, Sasja Heetveld, Emily M. Lynes, Melissa Castillo-Lizardo, Ashutosh Dhingra, Elwira Pyz, Markus Hobert, Matthis Synofzik, Javier Simón-Sánchez, Margherita Francescatto, Peter Heutink
Rewiring neuronal microcircuits of the brain via spine head protrusions-a role for synaptopodin and intracellular calcium stores
David Verbich, Denise Becker, Andreas Vlachos, Peter Mundel, Thomas Deller, R. Anne McKinney
Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease
Lars Tatenhorst, Katrin Eckermann, Vivian Dambeck, Luis Fonseca-Ornelas, Hagen Walle, Tomás Lopes da Fonseca, Jan C. Koch, Stefan Becker, Lars Tönges, Mathias Bähr, Tiago F. Outeiro, Markus Zweckstetter, Paul Lingor
TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy
Helga D. Munch-Petersen, Fazila Asmar, Konstantinos Dimopoulos, Aušrinė Areškevičiūtė, Peter Brown, Mia Seremet Girkov, Anja Pedersen, Lene D. Sjö, Steffen Heegaard, Helle Broholm, Lasse S. Kristensen, Elisabeth Ralfkiaer, Kirsten Grønbæk
Neuronal accumulation of unrepaired DNA in a novel specific chromatin domain: structural, molecular and transcriptional characterization
Jorge Mata-Garrido, Iñigo Casafont, Olga Tapia, Maria T. Berciano, Miguel Lafarga
Clobetasol promotes remyelination in a mouse model of neuromyelitis optica
Xiaoming Yao, Tao Su, A. S. Verkman
ALS-linked misfolded SOD1 species have divergent impacts on mitochondria
Sarah Pickles, Sabrina Semmler, Helen R. Broom, Laurie Destroismaisons, Laurine Legroux, Nathalie Arbour, Elizabeth Meiering, Neil R. Cashman, Christine Vande Velde
Downstream effects of plectin mutations in epidermolysis bullosa simplex with muscular dystrophy
Lilli Winter, Matthias Türk, Patrick N. Harter, Michel Mittelbronn, Cornelia Kornblum, Fiona Norwood, Heinz Jungbluth, Christian T. Thiel, Ursula Schlötzer-Schrehardt, Rolf Schröder
Differential roles of hypoxia and innate immunity in juvenile and adult dermatomyositis
Corinna Preuße, Yves Allenbach, Olaf Hoffmann, Hans-Hilmar Goebel, Debora Pehl, Josefine Radke, Alexandra Doeser, Udo Schneider, Rieke H.E. Alten, Tilmann Kallinich, Olivier Benveniste, Arpad von Moers, Benedikt Schoser, Ulrike Schara, Werner Stenzel
Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation
Arnulf H. Koeppen, R. Liane Ramirez, Alyssa B. Becker, Joseph E. Mazurkiewicz
Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts
Elisa Onesto, Claudia Colombrita, Valentina Gumina, Maria Orietta Borghi, Sabrina Dusi, Alberto Doretti, Gigliola Fagiolari, Federica Invernizzi, Maurizio Moggio, Valeria Tiranti, Vincenzo Silani, Antonia Ratti
Sustained expression of MCP-1 by low wall shear stress loading concomitant with turbulent flow on endothelial cells of intracranial aneurysm
Tomohiro Aoki, Kimiko Yamamoto, Miyuki Fukuda, Yuji Shimogonya, Shunichi Fukuda, Shuh Narumiya
Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease
Dawn H. W. Lau, Marte Hogseth, Emma C. Phillips, Michael J. O’Neill, Amy M. Pooler, Wendy Noble, Diane P. Hanger
V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis
Mercedes Valls Serón, Bart Ferwerda, JooYeon Engelen-Lee, Madelijn Geldhoff, Valery Jaspers, Aeilko H. Zwinderman, Michael W. Tanck, Frank Baas, Arie van der Ende, Matthijs C. Brouwer, Diederik van de Beek
The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway
Peter M. Sullivan, Xiaolai Zhou, Adam M. Robins, Daniel H. Paushter, Dongsung Kim, Marcus B. Smolka, Fenghua Hu
Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C
A. Dardis, S. Zampieri, S. Canterini, K. L. Newell, C. Stuani, J. R. Murrell, B. Ghetti, M. T. Fiorenza, B. Bembi, E. Buratti
Purkinje cell injury, structural plasticity and fusion in patients with Friedreich’s ataxia
Kevin C. Kemp, Amelia J. Cook, Juliana Redondo, Kathreena M. Kurian, Neil J. Scolding, Alastair Wilkins
DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas
Jennie N. Jeyapalan, Gabriel T. Doctor, Tania A. Jones, Samuel N. Alberman, Alexander Tep, Chirag M. Haria, Edward C. Schwalbe, Isabel C. F. Morley, Alfred A. Hill, Magdalena LeCain, Diego Ottaviani, Steven C. Clifford, Ibrahim Qaddoumi, Ruth G. Tatevossian, David W. Ellison, Denise Sheer
NHERF1/EBP50 and NF2 as diagnostic markers for choroid plexus tumors
Maria-Magdalena Georgescu, Bret C. Mobley, Brent A. Orr, Ping Shang, Norman L. Lehman, Xiaoping Zhu, Thomas J. O’Neill, Veena Rajaram, Kimmo J. Hatanpaa, Charles F. Timmons, Jack M. Raisanen
Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study
Donato Iacovazzo, Richard Caswell, Benjamin Bunce, Sian Jose, Bo Yuan, Laura C. Hernández-Ramírez, Sonal Kapur, Francisca Caimari, Jane Evanson, Francesco Ferraù, Mary N. Dang, Plamena Gabrovska, Sarah J. Larkin, Olaf Ansorge, Celia Rodd, Mary L. Vance, Claudia Ramírez-Renteria, Moisés Mercado, Anthony P. Goldstone, Michael Buchfelder, Christine P. Burren, Alper Gurlek, Pinaki Dutta, Catherine S. Choong, Timothy Cheetham, Giampaolo Trivellin, Constantine A. Stratakis, Maria-Beatriz Lopes, Ashley B. Grossman, Jacqueline Trouillas, James R. Lupski, Sian Ellard, Julian R. Sampson, Federico Roncaroli, Márta Korbonits
Imaging Invasion: Micro-CT imaging of adamantinomatous craniopharyngioma highlights cell type specific spatial relationships of tissue invasion
John R. Apps, J. Ciaran Hutchinson, Owen J. Arthurs, Alex Virasami, Abhijit Joshi, Berit Zeller-Plumhoff, Dale Moulding, Thomas S. Jacques, Neil J. Sebire, Juan Pedro Martinez-Barbera
An autoradiographic evaluation of AV-1451 Tau PET in dementia
Val J. Lowe, Geoffry Curran, Ping Fang, Amanda M. Liesinger, Keith A. Josephs, Joseph E. Parisi, Kejal Kantarci, Bradley F. Boeve, Mukesh K. Pandey, Tyler Bruinsma, David S. Knopman, David T. Jones, Leonard Petrucelli, Casey N. Cook, Neill R. Graff-Radford, Dennis W. Dickson, Ronald C. Petersen, Clifford R. Jack Jr., Melissa E. Murray
ARTAG in the basal forebrain: widening the constellation of astrocytic tau pathology
Alan King Lun Liu, Marc H. Goldfinger, Hayleigh E. Questari, Ronald K. B. Pearce, Steve M. Gentleman
ATRX immunostaining predicts IDH and H3F3A status in gliomas
Azadeh Ebrahimi, Marco Skardelly, Irina Bonzheim, Ines Ott, Helmut Mühleisen, Franziska Eckert, Ghazaleh Tabatabai, Jens Schittenhelm
Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes
Ryoko Takeuchi, Mari Tada, Atsushi Shiga, Yasuko Toyoshima, Takuya Konno, Tomoe Sato, Hiroaki Nozaki, Taisuke Kato, Masao Horie, Hiroshi Shimizu, Hirohide Takebayashi, Osamu Onodera, Masatoyo Nishizawa, Akiyoshi Kakita, Hitoshi Takahashi
Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease
Amit K. Chouhan, Caiwei Guo, Yi-Chen Hsieh, Hui Ye, Mumine Senturk, Zhongyuan Zuo, Yarong Li, Shreyasi Chatterjee, Juan Botas, George R. Jackson, Hugo J. Bellen, Joshua M. Shulman
Increased tauopathy drives microglia-mediated clearance of beta-amyloid
Wesley Chen, Edsel A. Abud, Stephen T. Yeung, Anita Lakatos, Trevor Nassi, Jane Wang, David Blum, Luc Buée, Wayne W. Poon, Mathew Blurton-Jones
Notch1 hallmarks fibrillary depositions in sporadic Alzheimer’s disease
Emanuele Brai, Noemi Alina Raio, Lavinia Alberi
The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer’s disease
Luke W. Bonham, Rahul S. Desikan, Jennifer S. Yokoyama
Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations
Ahmad A. Khundakar, Peter S. Hanson, Daniel Erskine, Nichola Z. Lax, Joseph Roscamp, Evangelia Karyka, Eliona Tsefou, Preeti Singh, Simon J. Cockell, Andrew Gribben, Lynne Ramsay, Peter G. Blain, Urs P. Mosimann, Deborah J. Lett, Matthias Elstner, Douglass M. Turnbull, Charles C. Xiang, Michael J. Brownstein, John T. O’Brien, John-Paul Taylor, Johannes Attems, Alan J. Thomas, Ian G. McKeith, Christopher M. Morris
Erratum to: ‘Purkinje cell injury, structural plasticity and fusion in patients with Friedreich’s ataxia’
Kevin C. Kemp, Amelia J. Cook, Juliana Redondo, Kathreena M. Kurian, Neil J. Scolding, Alastair Wilkins
LRP1 expression in microglia is protective during CNS autoimmunity
Tzu-Ying Chuang, Yong Guo, Scott M. Seki, Abagail M. Rosen, David M. Johanson, James W. Mandell, Claudia F. Lucchinetti, Alban Gaultier
Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes
Takayuki Kondo, Misato Funayama, Michiyo Miyake, Kayoko Tsukita, Takumi Era, Hitoshi Osaka, Takashi Ayaki, Ryosuke Takahashi, Haruhisa Inoue
From animal models to human disease: a genetic approach for personalized medicine in ALS
Vincent Picher-Martel, Paul N. Valdmanis, Peter V. Gould, Jean-Pierre Julien, Nicolas Dupré
A comprehensive next generation sequencing-based virome assessment in brain tissue suggests no major virus - tumor association
Michael J. Strong, Eugene Blanchard 4th, Zhen Lin, Cindy A. Morris, Melody Baddoo, Christopher M. Taylor, Marcus L. Ware, Erik K. Flemington
Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype
Myles R. Minter, Zachery Moore, Moses Zhang, Kate M. Brody, Nigel C. Jones, Sandy R. Shultz, Juliet M. Taylor, Peter J. Crack
BK virus encephalopathy and sclerosing vasculopathy in a patient with hypohidrotic ectodermal dysplasia and immunodeficiency
Armine Darbinyan, Eugene O. Major, Susan Morgello, Steven Holland, Caroline Ryschkewitsch, Maria Chiara Monaco, Thomas P. Naidich, Joshua Bederson, Joanna Malaczynska, Fei Ye, Ronald Gordon, Charlotte Cunningham-Rundles, Mary Fowkes, Nadejda M. Tsankova
Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation
Anthony Papegaey, Sabiha Eddarkaoui, Vincent Deramecourt, Francisco-Jose Fernandez-Gomez, Pierre Pantano, Hélène Obriot, Camille Machala, Vincent Anquetil, Agnès Camuzat, Alexis Brice, Claude-Alain Maurage, Isabelle Le Ber, Charles Duyckaerts, Luc Buée, Nicolas Sergeant, Valérie Buée-Scherrer
Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system
Debbie Allan, Karen J. Fairlie-Clarke, Christina Elliott, Cornelia Schuh, Susan C. Barnett, Hans Lassmann, Christopher Linnington, Hui-Rong Jiang
Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia
Raman Saggu, Toni Schumacher, Florian Gerich, Cordula Rakers, Khalid Tai, Andrea Delekate, Gabor C. Petzold
Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1G93A mouse model of amyotrophic lateral sclerosis
Matthew J. Fogarty, Erica W. H. Mu, Peter G. Noakes, Nickolas A. Lavidis, Mark C. Bellingham
Human neuronal changes in brain edema and increased intracranial pressure
Nóra Faragó, Ágnes Katalin Kocsis, Csilla Braskó, Sándor Lovas, Márton Rózsa, Judith Baka, Balázs Kovács, Katalin Mikite, Viktor Szemenyei, Gábor Molnár, Attila Ozsvár, Gáspár Oláh, Ildikó Piszár, Ágnes Zvara, Attila Patócs, Pál Barzó, László G. Puskás, Gábor Tamás
A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas
Hideyuki Arita, Kai Yamasaki, Yuko Matsushita, Taishi Nakamura, Asanao Shimokawa, Hirokazu Takami, Shota Tanaka, Akitake Mukasa, Mitsuaki Shirahata, Saki Shimizu, Kaori Suzuki, Kuniaki Saito, Keiichi Kobayashi, Fumi Higuchi, Takeo Uzuka, Ryohei Otani, Kaoru Tamura, Kazutaka Sumita, Makoto Ohno, Yasuji Miyakita, Naoki Kagawa, Naoya Hashimoto, Ryusuke Hatae, Koji Yoshimoto, Naoki Shinojima, Hideo Nakamura, Yonehiro Kanemura, Yoshiko Okita, Manabu Kinoshita, Kenichi Ishibashi, Tomoko Shofuda, Yoshinori Kodama, Kanji Mori, Yusuke Tomogane, Junya Fukai, Koji Fujita, Yuzo Terakawa, Naohiro Tsuyuguchi, Shusuke Moriuchi, Masahiro Nonaka, Hiroyoshi Suzuki, Makoto Shibuya, Taketoshi Maehara, Nobuhito Saito, Motoo Nagane, Nobutaka Kawahara, Keisuke Ueki, Toshiki Yoshimine, Etsuo Miyaoka, Ryo Nishikawa, Takashi Komori, Yoshitaka Narita, Koichi Ichimura
Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes
Nicola J. Rutherford, Mieu Brooks, Benoit I. Giasson
Disseminated necrotizing leukoencephalopathy eight months after alemtuzumab treatment for multiple sclerosis
Imke Metz, Peter Rieckmann, Boris-Alexander Kallmann, Wolfgang Brück
Aquaporin 4-specific T cells and NMO-IgG cause primary retinal damage in experimental NMO/SD
Bleranda Zeka, Maria Hastermann, Nathalie Kaufmann, Kathrin Schanda, Marko Pende, Tatsuro Misu, Paulus Rommer, Kazuo Fujihara, Ichiro Nakashima, Charlotte Dahle, Fritz Leutmezer, Markus Reindl, Hans Lassmann, Monika Bradl
Isoaspartic acid is present at specific sites in myelin basic protein from multiple sclerosis patients: could this represent a trigger for disease onset?
Michael G. Friedrich, Sarah E. Hancock, Mark J. Raftery, Roger J. W. Truscott
Pilocytic astrocytoma and glioneuronal tumor with histone H3 K27M mutation
Cordelia Orillac, Cheddhi Thomas, Yosef Dastagirzada, Eveline Teresa Hidalgo, John G. Golfinos, David Zagzag, Jeffrey H. Wisoff, Matthias A. Karajannis, Matija Snuderl
Diminishing evidence for torsinA-positive neuronal inclusions in DYT1 dystonia
Drew Pratt, Karin Mente, Shervin Rahimpour, Nancy A. Edwards, Sule Tinaz, Brian D. Berman, Mark Hallett, Abhik Ray-Chaudhury
The retina as an early biomarker of neurodegeneration in a rotenone-induced model of Parkinson’s disease: evidence for a neuroprotective effect of rosiglitazone in the eye and brain
Eduardo Maria Normando, Benjamin Michael Davis, Lies De Groef, Shereen Nizari, Lisa A. Turner, Nivedita Ravindran, Milena Pahlitzsch, Jonathan Brenton, Giulia Malaguarnera, Li Guo, Satyanarayana Somavarapu, Maria Francesca Cordeiro
Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model
Annika Scheffold, Inge R. Holtman, Sandra Dieni, Nieske Brouwer, Sarah-Fee Katz, Billy Michael Chelliah Jebaraj, Philipp J. Kahle, Bastian Hengerer, André Lechel, Stephan Stilgenbauer, Erik W. G. M. Boddeke, Bart J. L. Eggen, Karl-Lenhard Rudolph, Knut Biber
Chromosome 1q gain and tenascin-C expression are candidate markers to define different risk groups in pediatric posterior fossa ependymoma
Asuka Araki, Monika Chocholous, Johannes Gojo, Christian Dorfer, Thomas Czech, Harald Heinzl, Karin Dieckmann, Inge M. Ambros, Peter F. Ambros, Irene Slavc, Christine Haberler
Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy
Rana S. Dhillon, John Parker, Yasir A. Syed, Steve Edgley, Adam Young, James W. Fawcett, Nick D. Jeffery, Robin J. M. Franklin, Mark R. N. Kotter
Erratum to: Notch1 hallmarks fibrillary depositions in sporadic Alzheimer’s disease
E. Brai, N. Alina Raio, L. Alberi
Revisiting rodent models: Octodon degus as Alzheimer’s disease model?
Johannes Steffen, Markus Krohn, Kristin Paarmann, Christina Schwitlick, Thomas Brüning, Rita Marreiros, Andreas Müller-Schiffmann, Carsten Korth, Katharina Braun, Jens Pahnke
Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke
Johanna Rodhe, Miguel A. Burguillos, Rocio M. de Pablos, Edel Kavanagh, Annette Persson, Elisabet Englund, Tomas Deierborg, Jose L. Venero, Bertrand Joseph
Targeted detection of genetic alterations reveal the prognostic impact of H3K27M and MAPK pathway aberrations in paediatric thalamic glioma
Scott Ryall, Rahul Krishnatry, Anthony Arnoldo, Pawel Buczkowicz, Matthew Mistry, Robert Siddaway, Cino Ling, Sanja Pajovic, Man Yu, Joshua B. Rubin, Juliette Hukin, Paul Steinbok, Ute Bartels, Eric Bouffet, Uri Tabori, Cynthia Hawkins
Developmental delay in motor skill acquisition in Niemann-Pick C1 mice reveals abnormal cerebellar morphogenesis
Paola Caporali, Francesco Bruno, Giampiero Palladino, Jessica Dragotto, Laura Petrosini, Franco Mangia, Robert P. Erickson, Sonia Canterini, Maria Teresa Fiorenza
Systemic inflammation disrupts oligodendrocyte gap junctions and induces ER stress in a model of CNS manifestations of X-linked Charcot-Marie-Tooth disease
Margarita Olympiou, Irene Sargiannidou, Kyriaki Markoullis, Christos Karaiskos, Alexia Kagiava, Styliana Kyriakoudi, Charles K. Abrams, Kleopas A. Kleopa
Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma
Annika M. Bourgonje, Kiek Verrijp, Jan T. G. Schepens, Anna C. Navis, Jolanda A. F. Piepers, Chantal B. C. Palmen, Monique van den Eijnden, Rob Hooft van Huijsduijnen, Pieter Wesseling, William P. J. Leenders, Wiljan J. A. J. Hendriks
Neuropathology of supercentenarians - four autopsy case studies
Masaki Takao, Nobuyoshi Hirose, Yasumichi Arai, Ban Mihara, Masaru Mimura
Rare TREM2 variants associated with Alzheimer’s disease display reduced cell surface expression
Daniel W. Sirkis, Luke W. Bonham, Renan E. Aparicio, Ethan G. Geier, Eliana Marisa Ramos, Qing Wang, Anna Karydas, Zachary A. Miller, Bruce L. Miller, Giovanni Coppola, Jennifer S. Yokoyama
Pathogenesis of FUS-associated ALS and FTD: insights from rodent models
Matthew Nolan, Kevin Talbot, Olaf Ansorge
Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue
Thuy-Vi V. Nguyen, Jennifer B. Frye, Jacob C. Zbesko, Kristina Stepanovic, Megan Hayes, Alex Urzua, Geidy Serrano, Thomas G. Beach, Kristian P. Doyle
Erratum to: Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes
Takayuki Kondo, Misato Funayama, Michiyo Miyake, Kayoko Tsukita, Takumi Era, Hitoshi Osaka, Takashi Ayaki, Ryosuke Takahashi, Haruhisa Inoue
Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1
Sabine Sellner, Ricardo Paricio-Montesinos, Alena Spieß, Annette Masuch, Daniel Erny, Laura A. Harsan, Dominik v. Elverfeldt, Marius Schwabenland, Knut Biber, Ori Staszewski, Sergio Lira, Steffen Jung, Marco Prinz, Thomas Blank
Lipid microdomain modification sustains neuronal viability in models of Alzheimer’s disease
Silke Herzer, Sascha Meldner, Klara Rehder, Hermann-Josef Gröne, Viola Nordström
Erratum to: Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue
Thuy-Vi V. Nguyen, Jennifer B. Frye, Jacob C. Zbesko, Kristina Stepanovic, Megan Hayes, Alex Urzua, Geidy Serrano, Thomas G. Beach, Kristian P. Doyle
Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice
Krista J. Spiller, Clark R. Restrepo, Tahiyana Khan, Anna M. Stieber, Linda K. Kwong, John Q. Trojanowski, Virginia M.-Y. Lee
Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy
Vishruti Makani, Bin Zhang, Heeoon Han, Yuemang Yao, Pierrik Lassalas, Kevin Lou, Ian Paterson, Virginia M. Y. Lee, John Q. Trojanowski, Carlo Ballatore, Amos B. Smith III, Kurt R. Brunden
Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication Stage V)
Kentaro Hayashi, Yoko Mochizuki, Ryoko Takeuchi, Toshio Shimizu, Masahiro Nagao, Kazuhiko Watabe, Nobutaka Arai, Kiyomitsu Oyanagi, Osamu Onodera, Masaharu Hayashi, Hitoshi Takahashi, Akiyoshi Kakita, Eiji Isozaki
Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury
Chi Wang Ip, Ioannis U. Isaias, Burak B. Kusche-Tekin, Dennis Klein, Janos Groh, Aet O’Leary, Susanne Knorr, Takahiro Higuchi, James B. Koprich, Jonathan M. Brotchie, Klaus V. Toyka, Andreas Reif, Jens Volkmann
pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity
Oyinkan Sofola-Adesakin, Mobina Khericha, Inge Snoeren, Leo Tsuda, Linda Partridge
Amyloid-β 1–24 C-terminal truncated fragment promotes amyloid-β 1–42 aggregate formation in the healthy brain
Sonia Mazzitelli, Fabia Filipello, Marco Rasile, Eliana Lauranzano, Chiara Starvaggi-Cucuzza, Matteo Tamborini, Davide Pozzi, Isabella Barajon, Toni Giorgino, Antonino Natalello, Michela Matteoli
Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and cerebrovascular deficits in female mice
Riya Thomas, Paulina Zuchowska, Alan W. J. Morris, Felecia M. Marottoli, Sangeeta Sunny, Ryan Deaton, Peter H. Gann, Leon M. Tai
Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy
Jonathan D. Cherry, Yorghos Tripodis, Victor E. Alvarez, Bertrand Huber, Patrick T. Kiernan, Daniel H. Daneshvar, Jesse Mez, Philip H. Montenigro, Todd M. Solomon, Michael L. Alosco, Robert A. Stern, Ann C. McKee, Thor D. Stein
Activation of the unfolded protein response and granulovacuolar degeneration are not common features of human prion pathology
Vera I. Wiersma, Wim van Hecke, Wiep Scheper, Martijn A. J. van Osch, Will J. M. Hermsen, Annemieke J. M. Rozemuller, Jeroen J. M. Hoozemans
Hippocampal phospho-tau/MAPT neuropathology in the fornix in Alzheimer disease: an immunohistochemical autopsy study
Edward D. Plowey, Jennifer L. Ziskin
Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies
Steve Duleh, Xianhong Wang, Allison Komirenko, Marta Margeta
Nerve pathologic features differentiate POEMS syndrome from CIDP
Ezequiel A. Piccione, Janean Engelstad, Peter J. Dyck, Michelle L. Mauermann, Angela Dispenzieri, P. James B. Dyck
Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies
Meryem Tardivel, Séverine Bégard, Luc Bousset, Simon Dujardin, Audrey Coens, Ronald Melki, Luc Buée, Morvane Colin
Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX-
Toshiki Uchihara, Kentaro Endo, Hiromi Kondo, Sachi Okabayashi, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Eijiro Adachi, Nobuyuki Kimura
Rubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid
Blaine R. Roberts, James D. Doecke, Alan Rembach, L. Fernanda Yévenes, Christopher J. Fowler, Catriona A. McLean, Monica Lind, Irene Volitakis, Colin L. Masters, Ashley I. Bush, Dominic J. Hare
An autopsy-confirmed case of progressive supranuclear palsy with predominant postural instability
Carolin Kurz, Georg Ebersbach, Gesine Respondek, Armin Giese, Thomas Arzberger, Günter Ulrich Höglinger
Review of RyR1 pathway and associated pathomechanisms
Jessica W. Witherspoon, Katherine G. Meilleur
RETRACTED ARTICLE: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype
Christina Moloney, Sruti Rayaprolu, John Howard, Susan Fromholt, Hilda Brown, Matt Collins, Mariela Cabrera, Colin Duffy, Zoe Siemienski, Dave Miller, Maurice S. Swanson, Lucia Notterpek, David R. Borchelt, Jada Lewis
LRRK2 contributes to monocyte dysregulation in Parkinson’s disease
Corinna Bliederhaeuser, Lisa Zondler, Veselin Grozdanov, Wolfgang P. Ruf, David Brenner, Heather L. Melrose, Peter Bauer, Albert C. Ludolph, Frank Gillardon, Jan Kassubek, Jochen H. Weishaupt, Karin M. Danzer
Neuronal and glial changes in the brain resulting from explosive blast in an experimental model
James A. Goodrich, Jung H. Kim, Robert Situ, Wesley Taylor, Ted Westmoreland, Fu Du, Steven Parks, Geoffrey Ling, Jung Y. Hwang, Amedeo Rapuano, Faris A. Bandak, Nihal C. de Lanerolle
The identification of human pituitary adenoma-initiating cells
Branavan Manoranjan, Sujeivan Mahendram, Saleh A. Almenawer, Chitra Venugopal, Nicole McFarlane, Robin Hallett, Thusyanth Vijayakumar, Almunder Algird, Naresh K. Murty, Doron D. Sommer, John P. Provias, Kesava Reddy, Sheila K. Singh
Dopamine-2 receptor extracellular N-terminus regulates receptor surface availability and is the target of human pathogenic antibodies from children with movement and psychiatric disorders
Nese Sinmaz, Fiona Tea, Deepti Pilli, Alicia Zou, Mazen Amatoury, Tina Nguyen, Vera Merheb, Sudarshini Ramanathan, Sandra T. Cooper, Russell C. Dale, Fabienne Brilot
Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment
Benedicte Foveau, Steffen Albrecht, David A. Bennett, José A. Correa, Andrea C. LeBlanc
The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation
Diana F. Lázaro, Mariana Castro Dias, Anita Carija, Susanna Navarro, Carolina Silva Madaleno, Sandra Tenreiro, Salvador Ventura, Tiago F. Outeiro
Retraction Note to: A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD
Renate K. Hukema, Fréderike W. Riemslagh, Shamiram Melhem, Herma C. van der Linde, Lies-Anne W. F. M. Severijnen, Dieter Edbauer, Alex Maas, Nicolas Charlet-Berguerand, Rob Willemsen, John C. van Swieten
Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection
Milos D. Ikonomovic, Chris J. Buckley, Kerstin Heurling, Paul Sherwin, Paul A. Jones, Michelle Zanette, Chester A. Mathis, William E. Klunk, Aruna Chakrabarty, James Ironside, Azzam Ismail, Colin Smith, Dietmar R. Thal, Thomas G. Beach, Gill Farrar, Adrian P. L. Smith
β-Amyloid triggers aberrant over-scaling of homeostatic synaptic plasticity
James Gilbert, Shu Shu, Xin Yang, Youming Lu, Ling-Qiang Zhu, Heng-Ye Man