Ausgabe Sonderheft 1/2013
2nd Cross Company Respiratory Symposium
Inhalt (42 Artikel)
Models of respiratory disease symposium
Kathy H Abbott-Banner, Anthony Holmes, Ian Adcock, Navin L Rao, Edward Barrett, Richard Knowles
Assessment of the time course of chronic inflammation in the murine house dust mite model
Stephen M Jordan, Robert Carrington, David Lanham, James Cartwright, Rachel A Armstrong, Kenneth G Meecham
In-depth assessment of acute and chronic house dust mite-induced asthma mouse models
Rachel A Bunting, Josh Wertheimer, Zhao Zhou, Karyn Cochlin, Heather Deutsch, Holly Raymond, Ed Yurkow, Carol Anne Ogden, Ken Kilgore
Modulation of IL-17A and TL1A largely abrogates house dust mite-induced lung inflammation in murine model of allergic airway disease
C Hubeau, J Kubera, K Hammerman, J Wright J, M Denz, Y-T Juang, C Williams
Longitudinal characterisation of a model of chronic allergic lung inflammation in mice using imaging, functional and immunological methods
Kumar Changani, Catherine Pereira, Simon Young, Robert Shaw, Simon P Campbell, Kashmira Pindoria, Steve Jordan, Katherine Wiley, Sarah Bolton, Tony Nials, Michael Haase, Mike Pedrick, Richard Knowles
Acidic mammalian chitinase is not a critical target for allergic airway disease in mice
LJ Fitz, C DeClercq, J Brooks, W Kuang, B Bates, D Demers, A Winkler, K Nocka, A Jiao, RM Greco, LE Mason, M Fleming, A Quazi, J Wright, S Goldman, C Hubeau, CM Williams
Characterisation of the allergic phenotype resulting from a shortened HDM challenge protocol in mice
Sorif Uddin, Joanne Morley, Sara Hughes, Edith Hessel
Immunological characterisation of an acute murine model of lung inflammation and airway hyperreactivity
Kate L Dixon, Yee-Man Ching, Julie Coote, Neil Gozzard
Alterations in airway mechanics, inflammatory biomarkers and lung histopathology in a rat model of allergen-induced airway inflammation
Stephen M Jordan, Rachel A Armstrong, Jennifer Hincks, David Bell, Kenneth G Meecham
Brown Norway ovalbumin model: temporal profile of cytokines
Janice D Woodhouse, Alan Wilhelm, Michael Caniga, Malgorzata Gil, Jie Zhang-Hoover, Robbie McLeod, Lily Y Moy, Milenko Cicmil
Alternaria alternata induced inflammatory lung responses: a novel in vivo PK/PD model
Malgorzata Gil, Michael Caniga, Joseph Eckman, Robbie McLeod, Lily Moy, Alan Wilhelm, Janice Woodhouse, Jie Zhang-Hoover, Milenko Cicmil
Exploring the role of SYK in respiratory in vivo models
Michael Caniga, Janice D Woodhouse, Alan Wilhelm, Malgorzata A Gil, Yanlin Jia, Hongshi Yu, Stella Vincent, Richard Miller, Gissela Lieber, Xiomara Fernandez, Richard Chapman, Robbie McLeod, Lily Y Moy, Nancy Kelly, Emily Hickey, Michael A Crackower, Thomas Miller, William M Abraham, Milenko Cicmil
Time-course of inflammation and allergic bronchoconstrictor response in a model of ovalbumin-induced rapid pulmonary inflammation in Brown Norway rats
Sorif Uddin, Sara Hughes, Edith Hessel
Effect of the circadian cycle in Late Asthmatic Response (LAR). Comparison between two allergic asthma models in rats and mice
Raquel Otal, Sandra Muñoz, Elena Calama, Isabel Pagán, Félix Gil, Núria Torán, Montserrat Miralpeix, Jorge De Alba
A novel TLR-8 agonist attenuates nasal symptoms/congestion in both dog and human allergen challenge studies
Edward G Barrett, Karin Rudolph, Maura Matthews, Greg Dietsch, Robert Hershberg
Assessment of multiple pharmacological mechanisms in the ascaris sensitive sheep model of allergic asthma
Michael Caniga, Janice D Woodhouse, Alan Wilhelm, Malgorzata A Gil, Robbie McLeod, Lily Y Moy, Michael A Crackower, Thomas Miller, William M Abraham, Milenko Cicmil
Development of a model of Ascaris Suum antigen-induced pulmonary inflammation in nonhuman primates
Andrea G Bree, Franklin J Schlerman, Michael D Wadanoli, I-Ming Wang, Samuel J Goldman, Joseph P Sypek
Plasmacytoid dendritic cells downregulate the allergen induced T cell proliferation in a human in vitro allergy model
Frank Schaumann, Armin Braun, Meike Müller
Mast cell mediators cause the early allergic bronchoconstriction in guinea pigs in vivo: a model of relevance to asthma
Jason P Riley, Barbara Fuchs, Lisa Sjöberg, Gunnar P Nilsson, Lars Karlsson, Sven-Erik Dahlén, Navin L Rao, Mikael Adner
Strategies to mimic virally induced asthmatic exacerbations: the use of rhinovirus and influenza in acute and chronic mouse models
RJ Shaw, M Sowa, MS Pedrick, M Fife, AT Nials, RG Knowles, E Hessel
Impaired anti-viral immune response to human rhinovirus 1B infection in chronic allergic airway inflammation does not manifest in asthma exacerbation
Sabine Rochlitzer, Heinz-Gerd Hoymann, Armin Braun, Meike Müller
Poly I:C causes exacerbation in a murine allergic inflammation model driven by house dust mite in Freund's complete adjuvant
Jorge De Alba, Raquel Otal, Elena Calama, Félix Gil, Neil Gozzard, Montserrat Miralpeix
Mouse model of HDM induced airway inflammation + influenza or RSV. Effects of steroid
Dave Lamb, Christina Muir, Debbie Chappell, Hiroki Mori, Nicole Parker, Katy Hulland, Dominique Westbrook, Umar Burki, Jenny Hincks, Tony White, Vittorio Spampinato, Helen Bright, Steve Evans
Influenza exacerbations in an acute and chronic house dust mite ‘asthma’ model
Suzanne M Bal, Lara Ravanetti, Annemiek Dijkhuis, Rene Lutter
Antiviral effect of eosinophils in respiratory tract infection with influenza virus in mice
Suzanne M Bal, Annemiek Dijkhuis, Koen van der Sluijs, Rene Lutter
Characterization of MMP-9 and -12 KO mice in a model of acute smoke exposure
Franklin J Schlerman, John E Kubera, Stephen P Pazdziorko, Michael R Bowman, Bruce A Jacobson, Margaret Fleming, Cara MM Williams, Joseph P Sypek
Relative sensitivity of mice to inhaled ozone and cigarette smoke exposure
Rachel A Armstrong, Stephen M Jordan, Emma McConnell, Robert Carrington, Debbie Rodgers, Kenneth G Meecham
A translational approach to test anti-inflammatory drugs in a LPS induced acute lung inflammation model in the common marmoset (Callithrix jacchus)
S Seehase, S Switalla, V Neuhaus, M Zöller, FJ Kaup, C Schlumbohm, E Fuchs, HD Lauenstein, K Sewald, JM Hohlfeld, A Braun, S Knauf
Lipopolysaccharide (LPS) segmental lung challenge in nonhuman primates – a model of airway inflammation
Franklin J Schlerman, Andrea G Bree, Michael D Wadanoli, Samuel J Goldman, Cara MM Williams, Joseph P Sypek
Steroid insensitive respiratory inflammation - an acute tobacco smoke model
Hemanth Ramaprakash, Jason Riley, Navin L Rao
Steroid-insensitive tobacco smoke-induced lung inflammation models in the mouse
V Russell, D Spicer, P Woodman, A Connolly, A Young
A mouse model of acute exacerbations of lung inflammation in COPD with both steroid-sensitive and steroid-insensitive features
V Russell, A Connolly, C Jagger, D Spicer, P Woodman, J Dlugozima, A Young
Interleukin-6 neutralization alleviates acute exacerbation-like disease in a model of cigarette smoke-induced pulmonary inflammation
John Kubera, Katherine Hammerman, Cara MM Williams, Cedric Hubeau
A COPD-like model of viral exacerbation: synergistic effects with smoke and poly I:C
F Schlerman, J Kubera, M Fleming, K Nocka, C Williams
Strategies to improve lung absorption of intratracheally administered compounds in Drug Discovery
Elena Calama, Montserrat Vives, Isabel Ramis, Sonia Espinosa, Juan Pérez, Josep Maria Huerta, Jorge De Alba, Peter Eichhorn
Dry powder inhaled compound delivery for early pre-clinical in vivo efficacy studies
Robert Ives, Lindsay Butterfield, John Farr, Shaun Bater, Tony Nials, Lewis Entwistle, Doug Ball, Edith Hessel
Effects of Multikinase inhibitors on pressure overload-induced right ventricular remodelling
Baktybek Kojonazarov, Akylbek Sydykov, Soni Savai Pullamsetti, Himal Luitel, Bhola K Dahal, Djuro Kosanovic, Xia Tian, Matthaeus Majewski, Christin Baumann, Steve Evans, Peter Phillips, David Fairman, Neil Davie, Chris Wayman, Iain Kilty, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Hossein Ardeschir Ghofrani, Ralph Theo Schermuly
Therapeutic efficacy of Sunitinib and other broad spectrum receptor tyrosine kinase inhibitors (RTKI) in bleomycin-induced pulmonary fibrosis
D Knoerzer, T Baginski, K Wade, C Fan, S Rapp, K Regina, F Shih, M Burney, S Rouw, D Welsch
Considerations for therapeutic intervention models of pulmonary fibrosis
JA Wilder, M Doyle-Eisele, KM Gott, Y Shi, R Guilmette, A Gigliotti, J McDonald, IO Rosas
Do allergic dogs exhibit features of a severe steroid-resistant allergic airway phenotype?
Edward G Barrett, Christopher M Royer, Karin Rudolph, Phillip J Kuehl
Viral exacerbation of chronic airway inflammation in BALB/c mice sensitized with house dust mite (HDM): a role for corticosteroids?
Edward G Barrett, Al P Senft, Jennifer Nicodem, Dylan Armes, Aaron Gaskins, Ginevra Giannini