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Erschienen in: Die Kardiologie 3/2022

05.05.2022 | Stabile Angina pectoris | CME Zertifizierte Fortbildung

Antithrombotische Therapie bei Diabetes mellitus

Diabetes mellitus und kardiovaskuläre Erkrankungen

verfasst von: Dr. med. Lukas Andreas Heger, Daniel Duerschmied

Erschienen in: Die Kardiologie | Ausgabe 3/2022

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Zusammenfassung

Die Atherosklerose als chronische, obstruierende Gefäßentzündung verläuft progredient mit – teils wiederkehrenden – kardiovaskulären Ereignissen („major adverse cardiovascular event“ [MACE]). Patienten mit Diabetes mellitus (DM) haben aufgrund einer stärkeren Thrombozytenreaktivität ein deutlich erhöhtes Risiko für rezidivierende MACE. Die antithrombotische Therapie gewinnt daher zunehmend an Bedeutung. Laut den Ergebnissen der COMPASS-Studie verringert eine duale antithrombotische Therapie (DAT) mit ASS (Azetylsalizylsäure) und dem Faktor-Xa-Inhibitor Rivaroxaban in niedriger, vaskulärer Dosierung das Auftreten von MACE bei Hochrisikopatienten deutlich. Alternativ ist für Hochrisikopatienten mit chronischem Koronarsyndrom („chronic coronary syndrome“ [CCS]) eine verlängerte, ggf. auch dauerhafte, duale antithrombozytäre Therapie (DAPT) möglich, auch wenn unter dieser keine signifikante Reduktion der Mortalität nachgewiesen ist.
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Metadaten
Titel
Antithrombotische Therapie bei Diabetes mellitus
Diabetes mellitus und kardiovaskuläre Erkrankungen
verfasst von
Dr. med. Lukas Andreas Heger
Daniel Duerschmied
Publikationsdatum
05.05.2022
Verlag
Springer Medizin
Erschienen in
Die Kardiologie / Ausgabe 3/2022
Print ISSN: 2731-7129
Elektronische ISSN: 2731-7137
DOI
https://doi.org/10.1007/s12181-022-00557-1

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