Erschienen in:
07.02.2019 | Case Report - Vascular Neurosurgery - Ischemia
Stabilization of vulnerable carotid plaques with proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab
verfasst von:
Atsushi Ogata, Kazuhiko Oho, Noriaki Matsumoto, Jun Masuoka, Kohei Inoue, Motofumi Koguchi, Fumitaka Yoshioka, Tatsuya Abe
Erschienen in:
Acta Neurochirurgica
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Ausgabe 3/2019
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Abstract
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, a novel class of monoclonal antibodies, reduce low-density lipoprotein cholesterol levels and improve outcomes of myocardial infarction and stroke. However, the effects of PCSK9 inhibitors on carotid plaques remain unclear. We describe three patients treated with PCSK9 inhibitor alirocumab for progressive carotid stenosis despite lipid-lowering statin therapy. All three patients had vulnerable plaques on magnetic resonance (MR) plaque imaging. After alirocumab treatment initiation, no patients suffered stroke or adverse events, and the stabilization of the carotid plaques was observed on MR plaque imaging.