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Die Folgen des Klimwandels haben einen direkten Einfluss auf die Primärversorgung in Deutschland: Hitzeschutz insbesondere bei älteren Patienten, die Zunahme von Infektionen und die Verlängerung der Allergiesesaison spielen medizinisch eine bedeutsame Rolle. Aber auch in der Prävention und der Aufklärung der Patienten kommt den Hausärztinnen und -ärzten eine besondere Rolle zu. Direkt aus der Praxis berichtet im Live-Webinar am 13. Mai von 18 bis 19 Uhr unser Experte Dr. med. Robin Maitra.
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International Ophthalmology
Erschienen in: International Ophthalmology 10/2023

22.06.2023 | Review

Stages, pathogenesis, clinical management and advancements in therapies of age-related macular degeneration

verfasst von: Ishita Shome, Neethi C. Thathapudi, Bindu Madhav Reddy Aramati, Bhavani S. Kowtharapu, Jaganmohan R. Jangamreddy

Erschienen in: International Ophthalmology | Ausgabe 10/2023

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Abstract

Age-related macular degeneration (AMD) is a retinal degenerative disorder prevalent in the elderly population, which leads to the loss of central vision. The disease progression can be managed, if not prevented, either by blocking neovascularization (“wet” form of AMD) or by preserving retinal pigment epithelium and photoreceptor cells (“dry” form of AMD). Although current therapeutic modalities are moderately successful in delaying the progression and management of the disease, advances over the past years in regenerative medicine using iPSC, embryonic stem cells, advanced materials (including nanomaterials) and organ bio-printing show great prospects in restoring vision and efficient management of either forms of AMD. This review focuses on the molecular mechanism of the disease, model systems (both cellular and animal) used in studying AMD, the list of various regenerative therapies and the current treatments available. The article also highlights on the recent clinical trials using regenerative therapies and management of the disease.
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Metadaten
Titel
Stages, pathogenesis, clinical management and advancements in therapies of age-related macular degeneration
verfasst von
Ishita Shome
Neethi C. Thathapudi
Bindu Madhav Reddy Aramati
Bhavani S. Kowtharapu
Jaganmohan R. Jangamreddy
Publikationsdatum
22.06.2023
Verlag
Springer Netherlands
Erschienen in
International Ophthalmology / Ausgabe 10/2023
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-023-02767-2

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