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European Archives of Oto-Rhino-Laryngology

Erschienen in:

29.02.2016 | Head and Neck

Standardized pretreatment inflammatory laboratory markers and calculated ratios in patients with oral squamous cell carcinoma

verfasst von: Martin Grimm, Johan Rieth, Sebastian Hoefert, Michael Krimmel, Sven Rieth, Peter Teriete, Susanne Kluba, Thorsten Biegner, Adelheid Munz, Siegmar Reinert

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 10/2016

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Abstract

Analyzing the inflammatory microenvironment has become an important issue in the management of oral squamous cell carcinoma (OSCC). Pretreatment C-reactive protein (CRP) levels, leucocytes, monocytes, lymphocytes, neutrophils, basophils, eosinophils, platelets, neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) derived from the peripheral blood were analyzed. Receiver operating characteristic (ROC) curves determined a cut-off value for each parameter in 146 patients with OSCC compared with 93 controls and the results were associated with clinicopathological characteristics. CRP expression of tumors was measured by immunohistochemistry. ROC analysis determined cut-off values for CRP levels, leucocytes, monocytes, lymphocytes, neutrophils, NLR, dNLR, LMR, PLR and showed significant differences between the OSCC and control group. Compared with single laboratory tests calculated ratios were superior in measuring sensitivity and specificity of OSCC disease. NLR was significant directly associated and correlated with PLR. LMR was significant inversely associated and correlated with NLR and PLR. Immunohistochemical analysis did not show CRP expression of OSCCs. This study highlights the first analysis for cut-off values of pretreatment single laboratory tests and calculated ratios, which are strongly needed for a follow-up of cancer patients. Additionally, the calculated baselines can be used as a goal for successful immunotherapies in the future. The links between NLR, LMR, and PLR might be helpful for the clinical course (monitoring) of cancer patients and have been first described for OSCC in this study. Taken together, analyzing these data provides an additional practical guideline of further postoperative OSCC management.

Grimm M (2012) Prognostic value of clinicopathological parameters and outcome in 484 patients with oral squamous cell carcinoma: microvascular invasion (V+) is an independent prognostic factor for OSCC. Clin Transl Oncol 14(11):870–880. doi:10.1007/s12094-012-0867-2 PubMedCrossRef

Kreppel M, Eich HT, Kubler A, Zoller JE, Scheer M (2010) Prognostic value of the sixth edition of the UICC’s TNM classification and stage grouping for oral cancer. J Surg Oncol 102(5):443–449. doi:10.1002/jso.21547 PubMedCrossRef

Grandi C, Alloisio M, Moglia D, Podrecca S, Sala L, Salvatori P et al (1985) Prognostic significance of lymphatic spread in head and neck carcinomas: therapeutic implications. Head Neck Surg 8(2):67–73PubMedCrossRef

Greenberg JS, Fowler R, Gomez J, Mo V, Roberts D, El Naggar AK et al (2003) Extent of extracapsular spread: a critical prognosticator in oral tongue cancer. Cancer 97(6):1464–1470. doi:10.1002/cncr.11202 PubMedCrossRef

Sano D, Myers JN (2007) Metastasis of squamous cell carcinoma of the oral tongue. Cancer Metastasis Rev 26(3–4):645–662. doi:10.1007/s10555-007-9082-y PubMedCrossRef

Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420(6917):860–867. doi:10.1038/nature01322 PubMedPubMedCentralCrossRef

Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357(9255):539–545PubMedCrossRef

Balkwill F, Charles KA, Mantovani A (2005) Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 7(3):211–217. doi:10.1016/j.ccr.2005.02.013 PubMedCrossRef

Balkwill F, Coussens LM (2004) Cancer: an inflammatory link. Nature 431(7007):405–406PubMedCrossRef

10.

Choi S, Myers JN (2008) Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy. J Dent Res 87(1):14–32 (87/1/14 [pii]) PubMedCrossRef

11.

Grimm M, Lazariotou M (2012) Clinical relevance of a new pre-treatment laboratory prognostic index in patients with oral squamous cell carcinoma. Med Oncol 29(3):1435–1447. doi:10.1007/s12032-011-0045-3 PubMedCrossRef

12.

Apetoh L, Tesniere A, Ghiringhelli F, Kroemer G, Zitvogel L (2008) Molecular interactions between dying tumor cells and the innate immune system determine the efficacy of conventional anticancer therapies. Cancer Res 68(11):4026–4030. doi:10.1158/0008-5472.CAN-08-0427 PubMedCrossRef

13.

Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ et al (2004) IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118(3):285–296. doi:10.1016/j.cell.2004.07.013S0092867404006713 PubMedCrossRef

14.

Fang HY, Huang XY, Chien HT, Chang JT, Liao CT, Huang JJ et al (2013) Refining the role of preoperative C-reactive protein by neutrophil/lymphocyte ratio in oral cavity squamous cell carcinoma. Laryngoscope 123(11):2690–2699. doi:10.1002/lary.24105 PubMedCrossRef

15.

Chen YW, Chen IL, Lin IC, Kao SY (2014) Prognostic value of hypercalcaemia and leucocytosis in resected oral squamous cell carcinoma. Brit J Oral Maxillofac Surg 52(5):425–431. doi:10.1016/j.bjoms.2014.02.014 CrossRef

16.

Tsai YD, Wang CP, Chen CY, Lin LW, Hwang TZ, Lu LF et al (2014) Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity cancer. Head Neck 36(7):947–953. doi:10.1002/hed.23400 PubMedCrossRef

17.

Huang SH, Waldron JN, Milosevic M, Shen X, Ringash J, Su J et al (2015) Prognostic value of pretreatment circulating neutrophils, monocytes, and lymphocytes in oropharyngeal cancer stratified by human papillomavirus status. Cancer 121(4):545–555. doi:10.1002/cncr.29100 PubMedCrossRef

18.

Grimm M, Feyen O, Hofmann H, Teriete P, Biegner T, Munz A et al (2015) Immunophenotyping of patients with oral squamous cell carcinoma in peripheral blood and associated tumor tissue. Tumour Biol. doi:10.1007/s13277-015-4224-2 PubMed

19.

Lin GN, Peng JW, Liu DY, Xiao JJ, Chen YQ, Chen XQ (2014) Increased lymphocyte to monocyte ratio is associated with better prognosis in patients with newly diagnosed metastatic nasopharyngeal carcinoma receiving chemotherapy. Tumour Biol 35(11):10849–10854. doi:10.1007/s13277-014-2362-6 PubMedCrossRef

20.

Glogauer JE, Sun CX, Bradley G, Magalhaes MA (2015) Neutrophils increase oral squamous cell carcinoma invasion through an invadopodia-dependent pathway. Cancer Immunol Res. doi:10.1158/2326-6066.CIR-15-0017 PubMed

21.

Magalhaes MA, Glogauer JE, Glogauer M (2014) Neutrophils and oral squamous cell carcinoma: lessons learned and future directions. J Leukoc Biol 96(5):695–702. doi:10.1189/jlb.4RU0614-294R PubMedCrossRef

22.

Wimazal F, Germing U, Kundi M, Noesslinger T, Blum S, Geissler P et al (2010) Evaluation of the prognostic significance of eosinophilia and basophilia in a larger cohort of patients with myelodysplastic syndromes. Cancer 116(10):2372–2381. doi:10.1002/cncr.25036 PubMed

23.

Jain M, Kasetty S, Khan S, Jain NK (2014) Tissue eosinophilia in head and neck squamous neoplasia: an update. Exp Oncol 36(3):157–161PubMed

24.

Jain M, Kasetty S, Sudheendra US, Tijare M, Khan S, Desai A (2014) Assessment of tissue eosinophilia as a prognosticator in oral epithelial dysplasia and oral squamous cell carcinoma-an image analysis study. Pathol Res Int 2014:507512. doi:10.1155/2014/507512 CrossRef

25.

Pereira MC, Oliveira DT, Kowalski LP (2011) The role of eosinophils and eosinophil cationic protein in oral cancer: a review. Arch Oral Biol 56(4):353–358. doi:10.1016/j.archoralbio.2010.10.015 PubMedCrossRef

26.

Buergy D, Wenz F, Groden C, Brockmann MA (2012) Tumor–platelet interaction in solid tumors. Int J Cancer 130(12):2747–2760. doi:10.1002/ijc.27441 PubMedCrossRef

27.

Lu CC, Chang KW, Chou FC, Cheng CY, Liu CJ (2007) Association of pretreatment thrombocytosis with disease progression and survival in oral squamous cell carcinoma. Oral Oncol 43(3):283–288. doi:10.1016/j.oraloncology.2006.03.010 PubMedCrossRef

28.

Kargus S, Weber FE, Luebbers HT, Zemann W, Graetz KW, Kruse AL (2012) Pretreatment thrombocytosis: a prognostic marker for oral squamous cell carcinoma? Oral Maxillofac Surg 16(2):197–200. doi:10.1007/s10006-011-0305-6 PubMedCrossRef

29.

Perisanidis C, Kornek G, Poschl PW, Holzinger D, Pirklbauer K, Schopper C et al (2013) High neutrophil-to-lymphocyte ratio is an independent marker of poor disease-specific survival in patients with oral cancer. Med Oncol 30(1):334. doi:10.1007/s12032-012-0334-5 PubMedCrossRef

30.

Sun W, Zhang L, Luo M, Hu G, Mei Q, Liu D et al (2015) Pretreatment hematologic markers as prognostic factors in patients with nasopharyngeal carcinoma: neutrophil-lymphocyte ratio and platelet–lymphocyte ratio. Head Neck. doi:10.1002/hed.24224

31.

Rachidi S, Wallace K, Wrangle JM, Day TA, Alberg AJ, Li Z (2015) Neutrophil-to-lymphocyte ratio and overall survival in all sites of head and neck squamous cell carcinoma. Head Neck. doi:10.1002/hed.24159 PubMedPubMedCentral

32.

Feng JF, Huang Y, Chen QX (2014) Preoperative platelet lymphocyte ratio (PLR) is superior to neutrophil lymphocyte ratio (NLR) as a predictive factor in patients with esophageal squamous cell carcinoma. World J Surg Oncol 12:58. doi:10.1186/1477-7819-12-58 PubMedPubMedCentralCrossRef

33.

Feng JF, Huang Y, Zhao Q, Chen QX (2013) Clinical significance of preoperative neutrophil lymphocyte ratio versus platelet lymphocyte ratio in patients with small cell carcinoma of the esophagus. Sci World J 2013:504365. doi:10.1155/2013/504365

34.

Millrud CR, Mansson Kvarnhammar A, Uddman R, Bjornsson S, Riesbeck K, Cardell LO (2012) The activation pattern of blood leukocytes in head and neck squamous cell carcinoma is correlated to survival. PLoS One 7(12):e51120. doi:10.1371/journal.pone.0051120 PubMedPubMedCentralCrossRef

35.

Rassouli A, Saliba J, Castano R, Hier M, Zeitouni AG (2015) Systemic inflammatory markers as independent prognosticators of head and neck squamous cell carcinoma. Head Neck 37(1):103–110. doi:10.1002/hed.23567 PubMedCrossRef

36.

Deng Q, He B, Liu X, Yue J, Ying H, Pan Y et al (2015) Prognostic value of pre-operative inflammatory response biomarkers in gastric cancer patients and the construction of a predictive model. J Transl Med 13:66. doi:10.1186/s12967-015-0409-0 PubMedPubMedCentralCrossRef

37.

Tu XP, Qiu QH, Chen LS, Luo XN, Lu ZM, Zhang SY et al (2015) Preoperative neutrophil-to-lymphocyte ratio is an independent prognostic marker in patients with laryngeal squamous cell carcinoma. BMC Cancer 15:743. doi:10.1186/s12885-015-1727-6 PubMedPubMedCentralCrossRef

38.

Templeton AJ, McNamara MG, Seruga B, Vera-Badillo FE, Aneja P, Ocana A et al (2014) Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst 106(6):dju124. doi:10.1093/jnci/dju124 PubMedCrossRef

39.

He JR, Shen GP, Ren ZF, Qin H, Cui C, Zhang Y et al (2012) Pretreatment levels of peripheral neutrophils and lymphocytes as independent prognostic factors in patients with nasopharyngeal carcinoma. Head Neck 34(12):1769–1776. doi:10.1002/hed.22008 PubMedCrossRef

40.

An X, Ding PR, Wang FH, Jiang WQ, Li YH (2011) Elevated neutrophil to lymphocyte ratio predicts poor prognosis in nasopharyngeal carcinoma. Tumour Biol 32(2):317–324. doi:10.1007/s13277-010-0124-7 PubMedCrossRef

41.

Li J, Jiang R, Liu WS, Liu Q, Xu M, Feng QS et al (2013) A large cohort study reveals the association of elevated peripheral blood lymphocyte-to-monocyte ratio with favorable prognosis in nasopharyngeal carcinoma. PLoS One 8(12):e83069. doi:10.1371/journal.pone.0083069 PubMedPubMedCentralCrossRef

42.

Nishijima TF, Muss HB, Shachar SS, Tamura K, Takamatsu Y (2015) Prognostic value of lymphocyte-to-monocyte ratio in patients with solid tumors: a systematic review and meta-analysis. Cancer Treat Rev. doi:10.1016/j.ctrv.2015.10.003 PubMed

43.

Templeton AJ, Ace O, McNamara MG, Al-Mubarak M, Vera-Badillo FE, Hermanns T et al (2014) Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 23(7):1204–1212. doi:10.1158/1055-9965.EPI-14-0146 PubMedCrossRef

44.

Zhou X, Du Y, Huang Z, Xu J, Qiu T, Wang J et al (2014) Prognostic value of PLR in various cancers: a meta-analysis. PLoS One 9(6):e101119. doi:10.1371/journal.pone.0101119 PubMedPubMedCentralCrossRef

45.

Lee S, Oh SY, Kim SH, Lee JH, Kim MC, Kim KH et al (2013) Prognostic significance of neutrophil lymphocyte ratio and platelet lymphocyte ratio in advanced gastric cancer patients treated with FOLFOX chemotherapy. BMC Cancer 13:350. doi:10.1186/1471-2407-13-350 PubMedPubMedCentralCrossRef

46.

Grimm M, Calgeer B, Teriete P, Biegner T, Munz A, Reinert S (2015) Targeting thiamine-dependent enzymes for metabolic therapies in oral squamous cell carcinoma? Clin Transl Oncol. doi:10.1007/s12094-015-1352-5 PubMed

47.

Driemel O, Hertel K, Reichert TE, Kosmehl H (2006) Current classification of precursor lesions of oral squamous cell carcinoma principles of the WHO classification 2005. Mund Kiefer Gesichtschir 10(2):89–93. doi:10.1007/s10006-006-0675-3 PubMedCrossRef

48.

Sobin LH, Wittekind CH (2010) UICC. TNM classification of malignant tumors, 7th edn. Springer, Berlin

49.

Hamilton SR, Aaltonen LA (2000) Pathology and genetics. Tumours of the digestive system, 3rd edn. IARC Press, Lyon

50.

Grimm M, Cetindis M, Lehmann M, Biegner T, Munz A, Teriete P et al (2014) Association of cancer metabolism-related proteins with oral carcinogenesis-indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma? J Transl Med 12:208. doi:10.1186/1479-5876-12-208 PubMedPubMedCentralCrossRef

51.

Walker RA (2006) Quantification of immunohistochemistry-issues concerning methods, utility and semiquantitative assessment I. Histopathology 49(4):406–410. doi:10.1111/j.1365-2559.2006.02514.x PubMedCrossRef

52.

Zweig MH, Campbell G (1993) Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 39(4):561–577PubMed

53.

Mehrazin R, Uzzo RG, Kutikov A, Ruth K, Tomaszewski JJ, Dulaimi E et al (2015) Lymphopenia is an independent predictor of inferior outcome in papillary renal cell carcinoma. Urol Oncol 33(9):388 e319–388-e325. doi:10.1016/j.urolonc.2014.06.004 CrossRef

54.

Thomas JS, Kabbinavar F (2015) Metastatic clear cell renal cell carcinoma: a review of current therapies and novel immunotherapies. Crit Rev Oncol Hematol. doi:10.1016/j.critrevonc.2015.07.009 PubMed

55.

Hughes T, Klairmont M, Sharfman WH, Kaufman HL (2015) Interleukin-2, Ipilimumab, and Anti-PD-1: clinical management and the evolving role of immunotherapy for the treatment of patients with metastatic melanoma. Cancer Biol Ther. doi:10.1080/15384047.2015.1095401 PubMed

56.

Cheriyan VT, Thomas C, Balaram P (2011) Augmentation of T-cell immune responses and signal transduction proteins in oral cancer patients: potential for IL-2-mediated immunotherapy. J Cancer Res Clin Oncol 137(10):1435–1444. doi:10.1007/s00432-011-1012-2 PubMedCrossRef

57.

Rabinowich H, Cohen R, Bruderman I, Steiner Z, Klajman A (1987) Functional analysis of mononuclear cells infiltrating into tumors: lysis of autologous human tumor cells by cultured infiltrating lymphocytes. Cancer Res 47(1):173–177PubMed

58.

Fogar P, Sperti C, Basso D, Sanzari MC, Greco E, Davoli C et al (2006) Decreased total lymphocyte counts in pancreatic cancer: an index of adverse outcome. Pancreas 32(1):22–28 (00006676-200601000-00004 [pii]) PubMedCrossRef

59.

Sarraf KM, Belcher E, Raevsky E, Nicholson AG, Goldstraw P, Lim E (2009) Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer. J Thorac Cardiovasc Surg 137(2):425–428. doi:10.1016/j.jtcvs.2008.05.046 PubMedCrossRef

60.

Dworacki G, Meidenbauer N, Kuss I, Hoffmann TK, Gooding W, Lotze M et al (2001) Decreased zeta chain expression and apoptosis in CD3+ peripheral blood T lymphocytes of patients with melanoma. Clin Cancer Res 7(3 Suppl):947s–957sPubMed

61.

Youn JI, Collazo M, Shalova IN, Biswas SK, Gabrilovich DI (2012) Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. J Leukoc Biol 91(1):167–181. doi:10.1189/jlb.0311177 PubMedPubMedCentralCrossRef

62.

Dirican A, Kucukzeybek BB, Alacacioglu A, Kucukzeybek Y, Erten C, Varol U et al (2015) Do the derived neutrophil to lymphocyte ratio and the neutrophil to lymphocyte ratio predict prognosis in breast cancer? Int J Clin Oncol 20(1):70–81. doi:10.1007/s10147-014-0672-8 PubMedCrossRef

63.

Cannon NA, Meyer J, Iyengar P, Ahn C, Westover KD, Choy H et al (2015) Neutrophil-lymphocyte and platelet-lymphocyte ratios as prognostic factors after stereotactic radiation therapy for early-stage non-small-cell lung cancer. J Thorac Oncol 10(2):280–285. doi:10.1097/JTO.0000000000000399 PubMedCrossRef

64.

Kim IY, You SH, Kim YW (2014) Neutrophil-lymphocyte ratio predicts pathologic tumor response and survival after preoperative chemoradiation for rectal cancer. BMC Surg 14:94. doi:10.1186/1471-2482-14-94 PubMedPubMedCentralCrossRef

65.

Schaider H, Oka M, Bogenrieder T, Nesbit M, Satyamoorthy K, Berking C et al (2003) Differential response of primary and metastatic melanomas to neutrophils attracted by IL-8. Int J Cancer 103(3):335–343. doi:10.1002/ijc.10775 PubMedCrossRef

66.

Di Carlo E, Forni G, Musiani P (2003) Neutrophils in the antitumoral immune response. Chem Immunol Allergy 83:182–203PubMedCrossRef

67.

Scapini P, Nesi L, Morini M, Tanghetti E, Belleri M, Noonan D et al (2002) Generation of biologically active angiostatin kringle 1–3 by activated human neutrophils. J Immunol 168(11):5798–5804PubMedCrossRef

68.

De Larco JE, Wuertz BR, Furcht LT (2004) The potential role of neutrophils in promoting the metastatic phenotype of tumors releasing interleukin-8. Clin Cancer Res 10(15):4895–4900. doi:10.1158/1078-0432.CCR-03-0760 PubMedCrossRef

69.

Petrie HT, Klassen LW, Kay HD (1985) Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes. J Immunol 134(1):230–234PubMed

70.

Kay HD, Smith DL (1983) Regulation of human lymphocyte-mediated natural killer (NK) cell activity. I. Inhibition in vitro by peripheral blood granulocytes. J Immunol 130(1):475–483PubMed

71.

Lissoni P, Brivio F, Fumagalli L, Messina G, Ghezzi V, Frontini L et al (2004) Efficacy of cancer chemotherapy in relation to the pretreatment number of lymphocytes in patients with metastatic solid tumors. Int J Biol Markers 19(2):135–140PubMed

72.

Estrov Z, Talpaz M, Mavligit G, Pazdur R, Harris D, Greenberg SM et al (1995) Elevated plasma thrombopoietic activity in patients with metastatic cancer-related thrombocytosis. Am J Med 98(6):551–558PubMedCrossRef

73.

Naugler WE, Karin M (2008) The wolf in sheep’s clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med 14(3):109–119. doi:10.1016/j.molmed.2007.12.007 PubMedCrossRef

74.

Fujita Y, Okamoto M, Goda H, Tano T, Nakashiro K, Sugita A et al (2014) Prognostic significance of interleukin-8 and CD163-positive cell-infiltration in tumor tissues in patients with oral squamous cell carcinoma. PLoS One 9(12):e110378. doi:10.1371/journal.pone.0110378 PubMedPubMedCentralCrossRef

75.

Anand M, Chodda SK, Parikh PM, Nadkarni JS (1998) Abnormal levels of proinflammatory cytokines in serum and monocyte cultures from patients with chronic myeloid leukemia in different stages, and their role in prognosis. Hematol Oncol 16(4):143–154PubMedCrossRef

76.

Torisu-Itakura H, Lee JH, Huynh Y, Ye X, Essner R, Morton DL (2007) Monocyte-derived IL-10 expression predicts prognosis of stage IV melanoma patients. J Immunother 30(8):831–838. doi:10.1097/CJI.0b013e318158795b PubMedCrossRef

77.

Pollard JW (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4(1):71–78. doi:10.1038/nrc1256 PubMedCrossRef

78.

Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140(6):883–899. doi:10.1016/j.cell.2010.01.025 PubMedPubMedCentralCrossRef

79.

Zygogianni AG, Kyrgias G, Karakitsos P, Psyrri A, Kouvaris J, Kelekis N et al (2011) Oral squamous cell cancer: early detection and the role of alcohol and smoking. Head Neck Oncol 3:2. doi:10.1186/1758-3284-3-2 PubMedPubMedCentralCrossRef

80.

Hasselbalch HC (2015) Smoking as a contributing factor for development of polycythemia vera and related neoplasms. Leuk Res. doi:10.1016/j.leukres.2015.09.002

81.

Weir AB, Lewis JB Jr, Arteta-Bulos R (2011) Chronic idiopathic neutrophilia: experience and recommendations. South Med J 104(7):499–504. doi:10.1097/SMJ.0b013e31821ec7cc PubMedCrossRef

82.

Shiels MS, Katki HA, Freedman ND, Purdue MP, Wentzensen N, Trabert B et al (2014) Cigarette smoking and variations in systemic immune and inflammation markers. J Natl Cancer Inst. doi:10.1093/jnci/dju294 PubMedPubMedCentral

83.

Jinno T, Kawano S, Maruse Y, Matsubara R, Goto Y, Sakamoto T et al (2015) Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma. Oncol Rep 33(5):2161–2168. doi:10.3892/or.2015.3838 PubMedPubMedCentral

84.

Watanabe H, Iwase M, Ohashi M, Nagumo M (2002) Role of interleukin-8 secreted from human oral squamous cell carcinoma cell lines. Oral Oncol 38(7):670–679PubMedCrossRef

85.

O’Riordain MG, Falconer JS, Maingay J, Fearon KC, Ross JA (1999) Peripheral blood cells from weight-losing cancer patients control the hepatic acute phase response by a primarily interleukin-6 dependent mechanism. Int J Oncol 15(4):823–827PubMed

86.

Wigmore SJ, Fearon KC, Sangster K, Maingay JP, Garden OJ, Ross JA (2002) Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer. Int J Oncol 21(4):881–886PubMed

87.

St John MA, Li Y, Zhou X, Denny P, Ho CM, Montemagno C et al (2004) Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 130(8):929–935. doi:10.1001/archotol.130.8.929 PubMedCrossRef

88.

Nozoe T, Korenaga D, Futatsugi M, Saeki H, Maehara Y, Sugimachi K (2003) Immunohistochemical expression of C-reactive protein in squamous cell carcinoma of the esophagus—significance as a tumor marker. Cancer Lett 192(1):89–95 (S0304383502006304 [pii]) PubMedCrossRef

89.

Jabs WJ, Busse M, Kruger S, Jocham D, Steinhoff J, Doehn C (2005) Expression of C-reactive protein by renal cell carcinomas and unaffected surrounding renal tissue. Kidney Int 68(5):2103–2110. doi:10.1111/j.1523-1755.2005.00666.x PubMedCrossRef

Titel: Standardized pretreatment inflammatory laboratory markers and calculated ratios in patients with oral squamous cell carcinoma
verfasst von: Martin Grimm
Johan Rieth
Sebastian Hoefert
Michael Krimmel
Sven Rieth
Peter Teriete
Susanne Kluba
Thorsten Biegner
Adelheid Munz
Siegmar Reinert
Publikationsdatum: 29.02.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 10/2016
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-016-3950-4

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Standardized pretreatment inflammatory laboratory markers and calculated ratios in patients with oral squamous cell carcinoma

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