Background
Results
Mutant SOD1 proteins localize to the Golgi and impede the polymerization of Golgi-derived microtubules
Mutant SOD1 causes up-regulation of Stathmin 1 and 2 gene expression
Ferraiuolo et al. 2007 | Presymptomatic G93A vs. Ctrl (P60) | Symptomatic G93A vs. Ctrl (P90) | Endstage G93A vs. Ctrl (P120) | ||||||
Gene Symbol | Regulation | Fold-Change |
P-Value | Regulation | Fold-Change |
P-Value | Regulation | Fold-Change |
P-Value |
Tbca | up | 1,74 | 1,61 E-01 | up | 1,13 | 6,11E-01 | down | 1,63 | 9,62E-02 |
Tbcb | up | 1,03 | 9,24E-01 | down | 1,08 | 7,49E-01 | down | 1,33 | 6,17E-02 |
Tbcc | down | 1,09 | 8,24E-01 | down | 1,25 | 4,57E-01 | up | 1,03 | 9,71E-01 |
Tbcd | down | 1,14 | 8,10E-01 | up | 1,07 | 7,65E-01 | down | 1,03 | 9,32E-01 |
Tbce | up | 1,29 | 6,22E-01 | up | 1,01 | 9,87E-01 | down | 1,07 | 9,18E-01 |
Tbcel | down | 1,07 | 9,21 E-01 | down | 1,12 | 7,91 E-01 | up | 1,10 | 8,09E-01 |
Nardo et al. 2013 | Presymptomatic C57 G93A vs. Ctrl | Onset C57 G93A vs. Ctrl | Symptomatic C57 G93A vs. Ctrl | ||||||
Gene | Regulation | Fold-Change |
P-Value | Regulation | Fold-Change |
P-Value | Regulation | Fold-Change |
P-Value |
Tbca | up | 1,23 | 1,81 E-01 | down | 1,03 | 8,53E-01 | up | 1,04 | 3,83E-01 |
Tbcb | up | 1,06 | 7,17E-01 | down | 1,15 | 5,21 E-01 | down | 1,04 | 8,46E-01 |
Tbcc | up | 1,16 | 2,81 E-01 | down | 1,10 | 2,12E-01 | up | 1,07 | 6,83E-01 |
Tbcd | up | 1,09 | 6,15E-01 | up | 1,01 | 9,47E-01 | up | 1,10 | 5,20E-01 |
Tbce | up | 1,11 | 6,02E-01 | up | 1,17 | 2,70E-01 | up | 1,10 | 1,05E-02 |
Tbcel | up | 1,06 | 6,01 E-01 | up | 1,10 | 4,47E-01 | down | 1,09 | 6,51E-01 |
Nardo et al. 2013 | Presymptomatic 129sv G93A vs. Ctrl | Onset 129sv G93A vs. Ctrl | Symptomatic 129sv G93A vs. Ctrl | ||||||
Gene | Regulation | Fold-Change |
P-Value | Regulation | Fold-Change |
P-Value | Regulation | Fold-Change |
P-Value |
Tbca | up | 1,11 | 5,19E-01 | down | 1,11 | 2,51 E-01 | down | 1,10 | 4,67E-01 |
Tbcb | up | 1,22 | 2,89E-01 | down | 1,45 | 3,00E-03 | down | 1,45 | 1,61E-02 |
Tbcc | up | 1,20 | 1,50E-01 | down | 1,23 | 4,28E-02 | down | 1,06 | 3,85E-01 |
Tbcd | up | 1,28 | 1,37E-01 | down | 1,11 | 4,26E-01 | down | 1,06 | 5,97E-01 |
Tbce | up | 1,17 | 2,44E-01 | down | 1,20 | 8,76E-03 | down | 1,05 | 5,69E-01 |
Tbcel | up | 1,10 | 6,18E-01 | up | 1,01 | 9,11E-01 | down | 1,02 | 8,61E-01 |
Ferraiuolo et al. 2007 | Presymptomatic G93A vs. Ctrl (P60) | Symptomatic G93A vs. Ctrl (P90) | Endstage G93A vs. Ctrl (P120) | ||||||
Gene | Regulation | Fold-Change |
P-Value | Regulation | Fold-Change |
P-Value | Regulation | Fold-Change |
P-Value |
Stmnl |
up
|
1,87
|
3,80E-02
| up | 1,21 | 4,54E-01 | down | 1,40 | 3,32E-01 |
Stmn2 | down | 1,03 | 9,47E-01 | down | 1,39 | 2,65E-01 | up | 1,91 | 3,96E-01 |
Stmn3 |
down
|
1,71
|
9,50E-03
| down | 1,44 | 2,73E-01 | down | 1,21 | 2,92E-01 |
Stmn4 | down | 1,02 | 9,61 E-01 | up | 1,39 | 5,15E-01 | up | 1,09 | 8,50E-01 |
Nardo et al. 2013 | Presymptomatic C57 G93A vs. Ctrl | Onset C57 G93A vs. Ctrl | Symptomatic C57 G93A vs. Ctrl | ||||||
Gene | Regulation | Fold-Change |
P-Value | Regulation | Fold-Change |
P-Value | Regulation | Fold-Change |
P-Value |
Stmnl | down | 1,35 | 9,31 E-02 | up | 1,17 | 1,49E-01 | up | 1,16 | 3,48E-01 |
Stmn2 | down | 1,05 | 8.98E-01 | down | 1,52 | 2,38E-01 | up | 1,36 | 4,89E-01 |
Stmn3 | up | 1,07 | 7.28E-01 | down | 1,24 | 1,41 E-02 | down | 1,14 | 1,50E-02 |
Stmn4 | down | 1,06 | 6,69E-01 | up | 1,43 | 1,63E-01 | up | 1,36 | 3,15E-02 |
Nardo et al. 2013 | Presymptomatic 129v G93A vs. Ctr | Onset 129sv G93A vs. Ctrl | Symptomatic 129sv G93A vs. Ctrl | ||||||
Gene | Regulation | Fold-Change |
P-Value | Regulation | Fold-Change |
P-Value | Regulation | Fold-Change |
P-Value |
Stmnl | up | 1,05 | 5,50E-01 | up | 1,06 | 3,40E-01 | down | 1,04 | 7,57E-01 |
Stmn2 |
up
|
1,63
|
1.98E-02
| down | 1,46 | 1,76E-01 | down | 1,71 | 9,08E-02 |
Stmn3 | up | 1,08 | 6,24E-01 | down | 1,25 | 6,38E-03 | down | 1,30 | 1,18E-02 |
Stmn4 | down | 1,13 | 3,75E-01 | up | 1,15 | 3,11E-01 | up | 1,23 | 2,98E-03 |
Perrin et al. 2006 | Presymptomatic G93A vs. Ctrl (P60) | Symptomatic G93A vs. Ctrl (P90) | Endstage G93A vs. Ctrl (P120) | ||||||
Gene | Regulation | Fold-Change |
P-Value | Regulation | Fold-Change |
P-Value | Regulation | Fold-Change |
P-Value |
Stmnl | down | 1,38 | nc | down | 1,38 | nc | up | 1,68 | 6,00E-02 |
Stmn2 | up | 1,20 | nc | up | 1,30 | 1,36E-01 | up | 1,12 | 6,44E-01 |
Stmn3 | down | 1,03 | nc | up | 1,07 | 5,63E-01 | down | 1,02 | 8,36E-01 |
Stmn4 | up | 1,75 | nc | up | 1,30 | 6,49E-01 | up | 1,85 | nc |