Skip to main content
Erschienen in: Breast Cancer Research 1/2012

01.02.2012 | Editorial

Steps solidifying a role for SEPT9 in breast cancer suggest that greater strides are needed

verfasst von: Laura Stanbery, Elizabeth M Petty

Erschienen in: Breast Cancer Research | Ausgabe 1/2012

Einloggen, um Zugang zu erhalten

Abstract

Septins comprise a conserved family of GTPase proteins. Of these, human SEPT9 has been widely implicated in cancers of epithelial origin, including breast cancer, as well as leukemia. In a previous issue of Breast Cancer Research, Connolly and colleagues present compelling data further supporting a role for SEPT9 isoforms in early breast cancer development as well as evidence suggesting that cellular localization patterns of SEPT9 isoforms may contribute to oncogenesis.
Literatur
1.
Zurück zum Zitat Connolly D, Yang Z, Castaldi M, Simmons N, Oktay MH, Coniglio S, Fazzari MJ, Verdier-Pinard P, Montagna C: Septin 9 isoform expression, localization and epigenetic changes during human and mouse breast cancer progression. Breast Cancer Res. 2011, 13: R76-10.1186/bcr2924.CrossRefPubMedPubMedCentral Connolly D, Yang Z, Castaldi M, Simmons N, Oktay MH, Coniglio S, Fazzari MJ, Verdier-Pinard P, Montagna C: Septin 9 isoform expression, localization and epigenetic changes during human and mouse breast cancer progression. Breast Cancer Res. 2011, 13: R76-10.1186/bcr2924.CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Hartwell LH: Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis. Exp Cell Res. 1971, 69: 265-276. 10.1016/0014-4827(71)90223-0.CrossRefPubMed Hartwell LH: Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis. Exp Cell Res. 1971, 69: 265-276. 10.1016/0014-4827(71)90223-0.CrossRefPubMed
3.
Zurück zum Zitat Russell SEH, Hall PA: Septin genomics: a road less travelled. Biol Chem. 2011, 392: 763-767. 10.1515/BC.2011.079.CrossRefPubMed Russell SEH, Hall PA: Septin genomics: a road less travelled. Biol Chem. 2011, 392: 763-767. 10.1515/BC.2011.079.CrossRefPubMed
4.
Zurück zum Zitat Peterson EA, Petty EM: Conquering the complex world of human septins: implications for health and disease. Clin Genet. 2010, 77: 511-524. 10.1111/j.1399-0004.2010.01392.x.CrossRefPubMedPubMedCentral Peterson EA, Petty EM: Conquering the complex world of human septins: implications for health and disease. Clin Genet. 2010, 77: 511-524. 10.1111/j.1399-0004.2010.01392.x.CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Connolly D, Abdesselam I, Verdier-Pinard P, Montagna C: Septin roles in tumorigenesis. Biol Chem. 2011, 392: 725-738. 10.1515/BC.2011.073.CrossRefPubMed Connolly D, Abdesselam I, Verdier-Pinard P, Montagna C: Septin roles in tumorigenesis. Biol Chem. 2011, 392: 725-738. 10.1515/BC.2011.073.CrossRefPubMed
6.
Zurück zum Zitat Roeseler S, Sandrock K, Bartsch I, Zieger B: Septins, a novel group of GTP-binding proteins: relevance in hemostasis, neuropathology and oncogenesis. Klin Padiatr. 2009, 221: 150-155. 10.1055/s-0029-1220706.CrossRefPubMed Roeseler S, Sandrock K, Bartsch I, Zieger B: Septins, a novel group of GTP-binding proteins: relevance in hemostasis, neuropathology and oncogenesis. Klin Padiatr. 2009, 221: 150-155. 10.1055/s-0029-1220706.CrossRefPubMed
7.
Zurück zum Zitat Osaka M, Rowley JD, Zeleznik-Le NJ: MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25). Proc Natl Acad Sci USA. 1999, 96: 6428-6433. 10.1073/pnas.96.11.6428.CrossRefPubMedPubMedCentral Osaka M, Rowley JD, Zeleznik-Le NJ: MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25). Proc Natl Acad Sci USA. 1999, 96: 6428-6433. 10.1073/pnas.96.11.6428.CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Kalikin LM, Sims HL, Petty EM: Genomic and expression analyses of alternatively spliced transcripts of the MLL septin-like fusion gene (MSF) that map to a 17q25 region of loss in breast and ovarian tumors. Genomics. 2000, 63: 165-172. 10.1006/geno.1999.6077.CrossRefPubMed Kalikin LM, Sims HL, Petty EM: Genomic and expression analyses of alternatively spliced transcripts of the MLL septin-like fusion gene (MSF) that map to a 17q25 region of loss in breast and ovarian tumors. Genomics. 2000, 63: 165-172. 10.1006/geno.1999.6077.CrossRefPubMed
9.
Zurück zum Zitat Russell SE, McIlhatton MA, Burrows JF, Donaghy PG, Chanduloy S, Petty EM, Kalikin LM, Church SW, McIlroy S, Harkin DP, Keilty GW, Cranston AN, Weissenbach J, Hickey I, Johnston PG: Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors. Cancer Res. 2000, 60: 4729-4734.PubMed Russell SE, McIlhatton MA, Burrows JF, Donaghy PG, Chanduloy S, Petty EM, Kalikin LM, Church SW, McIlroy S, Harkin DP, Keilty GW, Cranston AN, Weissenbach J, Hickey I, Johnston PG: Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors. Cancer Res. 2000, 60: 4729-4734.PubMed
10.
Zurück zum Zitat Sandrock K, Bartsch I, Busse A, Busse E, Zieger B: Characterization of human septin interactions. Biol Chem. 2011, 392: 751-761. 10.1515/BC.2011.081.CrossRefPubMed Sandrock K, Bartsch I, Busse A, Busse E, Zieger B: Characterization of human septin interactions. Biol Chem. 2011, 392: 751-761. 10.1515/BC.2011.081.CrossRefPubMed
11.
Zurück zum Zitat Peterson EA, Kalikin LM, Steels JD, Estey MP, Trimble WS, Petty EM: Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin. Mamm Genome. 2007, 18: 796-807. 10.1007/s00335-007-9065-x.CrossRefPubMed Peterson EA, Kalikin LM, Steels JD, Estey MP, Trimble WS, Petty EM: Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin. Mamm Genome. 2007, 18: 796-807. 10.1007/s00335-007-9065-x.CrossRefPubMed
12.
Zurück zum Zitat Gonzalez ME, Peterson EA, Privette LM, Loff reda-Wren JL, Kalikin LM, Petty EM: High SEPT9_v1 expression in human breast cancer cells is associated with oncogenic phenotypes. Cancer Res. 2007, 67: 8554-8564. 10.1158/0008-5472.CAN-07-1474.CrossRefPubMed Gonzalez ME, Peterson EA, Privette LM, Loff reda-Wren JL, Kalikin LM, Petty EM: High SEPT9_v1 expression in human breast cancer cells is associated with oncogenic phenotypes. Cancer Res. 2007, 67: 8554-8564. 10.1158/0008-5472.CAN-07-1474.CrossRefPubMed
13.
Zurück zum Zitat Stanbery L, D'Silva NJ, Lee JS, Bradford CR, Carey TE, Prince ME, Wolf GT, Worden FP, Cordell KG, Petty EM: High SEPT9_v1 expression is associated with poor clinical outcomes in head and neck squamous cell carcinoma. Transl Oncol. 2010, 3: 239-245.CrossRefPubMedPubMedCentral Stanbery L, D'Silva NJ, Lee JS, Bradford CR, Carey TE, Prince ME, Wolf GT, Worden FP, Cordell KG, Petty EM: High SEPT9_v1 expression is associated with poor clinical outcomes in head and neck squamous cell carcinoma. Transl Oncol. 2010, 3: 239-245.CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Amir S, Wang R, Matzkin H, Simons JW, Mabjeesh NJ: MSF-A interacts with hypoxia-inducible factor-1alpha and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis. Cancer Res. 2006, 66: 856-866. 10.1158/0008-5472.CAN-05-2738.CrossRefPubMed Amir S, Wang R, Matzkin H, Simons JW, Mabjeesh NJ: MSF-A interacts with hypoxia-inducible factor-1alpha and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis. Cancer Res. 2006, 66: 856-866. 10.1158/0008-5472.CAN-05-2738.CrossRefPubMed
15.
Zurück zum Zitat Bennett KL, Romigh T, Eng C: Disruption of transforming growth factorbeta signaling by five frequently methylated genes leads to head and neck squamous cell carcinoma pathogenesis. Cancer Res. 2009, 69: 9301-9305. 10.1158/0008-5472.CAN-09-3073.CrossRefPubMed Bennett KL, Romigh T, Eng C: Disruption of transforming growth factorbeta signaling by five frequently methylated genes leads to head and neck squamous cell carcinoma pathogenesis. Cancer Res. 2009, 69: 9301-9305. 10.1158/0008-5472.CAN-09-3073.CrossRefPubMed
16.
Zurück zum Zitat Toth K, Galamb O, Spisak S, Wichmann B, Sipos F, Valcz G, Leiszter K, Molnar B, Tulassay Z: The influence of methylated septin 9 gene on RNA and protein level in colorectal cancer. Pathol Oncol Res. 2011, 17: 503-509. 10.1007/s12253-010-9338-7.CrossRefPubMed Toth K, Galamb O, Spisak S, Wichmann B, Sipos F, Valcz G, Leiszter K, Molnar B, Tulassay Z: The influence of methylated septin 9 gene on RNA and protein level in colorectal cancer. Pathol Oncol Res. 2011, 17: 503-509. 10.1007/s12253-010-9338-7.CrossRefPubMed
17.
Zurück zum Zitat Hannibal MC, Ruzzo EK, Miller LR, Betz B, Buchan JG, Knutzen DM, Barnett K, Landsverk ML, Brice A, LeGuern E, Bedford HM, Worrall BB, Lovitt S, Appel SH, Andermann E, Bird TD, Chance PF: SEPT9 gene sequencing analysis reveals recurrent mutations in hereditary neuralgic amyotrophy. Neurology. 2009, 72: 1755-1759. 10.1212/WNL.0b013e3181a609e3.CrossRefPubMedPubMedCentral Hannibal MC, Ruzzo EK, Miller LR, Betz B, Buchan JG, Knutzen DM, Barnett K, Landsverk ML, Brice A, LeGuern E, Bedford HM, Worrall BB, Lovitt S, Appel SH, Andermann E, Bird TD, Chance PF: SEPT9 gene sequencing analysis reveals recurrent mutations in hereditary neuralgic amyotrophy. Neurology. 2009, 72: 1755-1759. 10.1212/WNL.0b013e3181a609e3.CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Amir S, Golan M, Mabjeesh NJ: Targeted knockdown of SEPT9_v1 inhibits tumor growth and angiogenesis of human prostate cancer cells concomitant with disruption of hypoxia-inducible factor-1 pathway. Mol Cancer Res. 2010, 8: 643-652. 10.1158/1541-7786.MCR-09-0497.CrossRefPubMed Amir S, Golan M, Mabjeesh NJ: Targeted knockdown of SEPT9_v1 inhibits tumor growth and angiogenesis of human prostate cancer cells concomitant with disruption of hypoxia-inducible factor-1 pathway. Mol Cancer Res. 2010, 8: 643-652. 10.1158/1541-7786.MCR-09-0497.CrossRefPubMed
19.
Zurück zum Zitat Gonzalez ME, Makarova O, Peterson EA, Privette LM, Petty EM: Up-regulation of SEPT9_v1 stabilizes c-Jun-N-terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells. Cell Signal. 2009, 21: 477-487. 10.1016/j.cellsig.2008.11.007.CrossRefPubMed Gonzalez ME, Makarova O, Peterson EA, Privette LM, Petty EM: Up-regulation of SEPT9_v1 stabilizes c-Jun-N-terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells. Cell Signal. 2009, 21: 477-487. 10.1016/j.cellsig.2008.11.007.CrossRefPubMed
20.
Zurück zum Zitat Surka MC, Tsang CW, Trimble WS: The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis. Mol Biol Cell. 2002, 13: 3532-3545. 10.1091/mbc.E02-01-0042.CrossRefPubMedPubMedCentral Surka MC, Tsang CW, Trimble WS: The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis. Mol Biol Cell. 2002, 13: 3532-3545. 10.1091/mbc.E02-01-0042.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Estey MP, Di Ciano-Oliveira C, Froese CD, Bejide MT, Trimble WS: Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission. J Cell Biol. 2010, 191: 741-749. 10.1083/jcb.201006031.CrossRefPubMedPubMedCentral Estey MP, Di Ciano-Oliveira C, Froese CD, Bejide MT, Trimble WS: Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission. J Cell Biol. 2010, 191: 741-749. 10.1083/jcb.201006031.CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Peterson EA, Stanbery L, Li C, Kocak H, Makarova O, Petty EM: SEPT9_i1 and genomic instability: Mechanistic insights and relevance to tumorigenesis. Genes Chromosomes Cancer. 2011, 50: 940-949. 10.1002/gcc.20916.CrossRefPubMedPubMedCentral Peterson EA, Stanbery L, Li C, Kocak H, Makarova O, Petty EM: SEPT9_i1 and genomic instability: Mechanistic insights and relevance to tumorigenesis. Genes Chromosomes Cancer. 2011, 50: 940-949. 10.1002/gcc.20916.CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Montagna C, Lyu MS, Hunter K, Lukes L, Lowther W, Repert T, Hissong B, Weaver Z, Reid T: The Septin 9 (MSF) gene is ampliofied and overexdpressed in mouse mammary gland ademocarcinomas and human breast cancer cell lines. Cancer Res. 2003, 63: 2179-2187.PubMed Montagna C, Lyu MS, Hunter K, Lukes L, Lowther W, Repert T, Hissong B, Weaver Z, Reid T: The Septin 9 (MSF) gene is ampliofied and overexdpressed in mouse mammary gland ademocarcinomas and human breast cancer cell lines. Cancer Res. 2003, 63: 2179-2187.PubMed
24.
Zurück zum Zitat deVos T, Tetzner R, Model F, Weiss G, Schuster M, Distler J, Steiger KV, Grützmann R, Pilarsky C, Habermann JK, Fleshner PR, Oubre BM, Day R, Sledziewski AZ, Lofton-Day C: Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer. Clin Chem. 2009, 55: 1337-1346. 10.1373/clinchem.2008.115808.CrossRefPubMed deVos T, Tetzner R, Model F, Weiss G, Schuster M, Distler J, Steiger KV, Grützmann R, Pilarsky C, Habermann JK, Fleshner PR, Oubre BM, Day R, Sledziewski AZ, Lofton-Day C: Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer. Clin Chem. 2009, 55: 1337-1346. 10.1373/clinchem.2008.115808.CrossRefPubMed
Metadaten
Titel
Steps solidifying a role for SEPT9 in breast cancer suggest that greater strides are needed
verfasst von
Laura Stanbery
Elizabeth M Petty
Publikationsdatum
01.02.2012
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 1/2012
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr3056

Weitere Artikel der Ausgabe 1/2012

Breast Cancer Research 1/2012 Zur Ausgabe

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

25.04.2024 NSCLC Nachrichten

Das Risiko für Rezidiv oder Tod von Patienten und Patientinnen mit reseziertem ALK-positivem NSCLC ist unter einer adjuvanten Therapie mit dem Tyrosinkinase-Inhibitor Alectinib signifikant geringer als unter platinbasierter Chemotherapie.

Bei Senioren mit Prostatakarzinom auf Anämie achten!

24.04.2024 DGIM 2024 Nachrichten

Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.

ICI-Therapie in der Schwangerschaft wird gut toleriert

Müssen sich Schwangere einer Krebstherapie unterziehen, rufen Immuncheckpointinhibitoren offenbar nicht mehr unerwünschte Wirkungen hervor als andere Mittel gegen Krebs.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.